L-5-Methyltetrahydrofolate Calcium is a white to yellowish crystalline powder, a naturally occurring calcium salt derivative of folic acid, and the most biologically active and functional form of folic acid, which is more easily absorbed than ordinary folic acid. In clinic, high-quality Levomefolate calcium is mainly used for homocysteine control, prenatal care, treatment of cardiovascular diseases, dementia and depression.
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Item |
Standard |
Test Results |
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Appearance |
White Powder |
Conform |
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Identification |
IR.HPLC |
Conform |
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Melting range |
≥300℃ |
＞300℃ |
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Loss on Drying |
≤ 1% |
0.13% |
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Heavy Metal |
≤ 10.0 mg/kg |
1.9 mg/kg |
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Pb |
≤ 2.0 mg/kg |
1.0mg/kg |
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As |
≤ 2.0 mg/kg |
0.1mg/kg |
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Hg |
≤ 2.0 mg/kg |
0.8mg/kg |
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Related substances |
any individual impurity ≤0 . 5% total impurities ≤ 1 . 0 % |
Pass |
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Assay |
≥99% |
99.45% |
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Total Plate Count |
≤ 1000cfu/g |
11.8 cfu/g |
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Yeast&Mold |
≤ 100cfu/g |
3.56 cfu/g |
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E.coil |
- |
Negative |
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Salmonella |
- |
Negative |
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Residue of Pesticide |
- |
Negative |
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| Conclusion： |
Conform with enterprise specification . |
What is the action mechanism of Levomefolate Calcium?
Calcium L-5-Methyltetrahydrofolate is widely used as a derivative of tetrahydrofolate. Levomefolate calcium raw powder has been identified as a general safe substance by FDA, which can be used as food additives and pharmaceutical additives. According to the biological activity study of folic acid, we know that Levomefolate Calcium involves a series of enzymatic reactions and cofactors. After absorption by the body, this product will be transformed into folic acid molecules with high activity, which will be reduced and methylated into 5-MTHF during the metabolism of intestinal mucosal cells. This transformation is limited and does not change the appearance of folic acid in blood circulation. Glutamate is subsequently converted into S-adenosylmethionine (SAMe), and methyl donors participate in many biochemical processes. It can also be used as a donor to participate in the synthesis of nucleotides and support the biosynthesis of DNA.
What are the functions of Levomefolate Calcium after absorption by the human body?
Lack of folic acid can reduce the ability of cells to synthesize and repair DNA, and further induce abnormal cell proliferation, loss of endothelial function, cardiovascular abnormalities, and decline in neurological function. Especially during pregnancy, supplementing with 5-MTHF has been shown to reduce the risk of neural tube defects and recurrence. And It is a calcium salt of L-5-methyltetrahydrofolate, belonging to the folate family of vitamins. There is evidence to suggest that if we supplement it reasonably, it may be a more favorable way to increase folate levels and reduce homocysteine levels, and support normal cell proliferation.
What are the latest advances in the study of metabolic pathway of Levomefolate Calcium?
Lack of folic acid is usually due to insufficient absorption caused by vitamin deficiency. During pregnancy and lactation, the need for folic acid is increased during the growth of children. Under the influence of absorption or metabolic changes or drugs, eating foods rich in folic acid cannot guarantee the provided dose, so it needs to be supplemented. Levomefolate calcium is a coenzyme form of folic acid. In the natural environment, 5-mthf powder is a naturally occurring salt-forming methyl derivative form of folic acid, so it is also called L-methylfolic acid, which is the most biologically active and functional form of folic acid and is easier to absorb than ordinary folic acid. However, ordinary folic acid must be converted into L-methyl folic acid to participate in two main metabolic pathways: methylation and dna synthesis. The only form of free folic acid that usually appears in human plasma and cells is 5-mthf, which is the latest discovery.
A variety of shipping methods for you to choose
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Transportation Time |
Shipping method |
Cargo weight requirements |
Advantage |
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3-7 days |
DHL,Germany DHL,Germany DPD, |
Suitable for under 50kg. |
We have warehouses in Germany and California, USA, |
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7-15 days |
By Air |
Suitable for more than 50kg. |
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15-60 days |
By Sea |
Suitable for more than 500kg. |
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