what is Cocarboxylase?
Cocarboxylase is a coenzyme form of vitamin B1 (thiamine), which is formed by phosphorylation of vitamin B1 (thiamine). Thiamine pyrophosphate TPP+is a coenzyme involved in the synthesis and cleavage of carbonyl carbon (aldehydes and ketones) in sugar metabolism, especially the decarboxylation of α - keto acids. Thiamine pyrophosphate promotes the cleavage of carboxyl group to release carbon dioxide by combining the carbon atom of n=C active site with α - carbon atom (carbonyl carbon atom).
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Product name |
Cocarboxylase |
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CAS |
154-87-0 |
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Molecular formula |
C12H19ClN4O7P2S | |
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Molecular weight |
460.767382 | |
| EINECS | 205-836-1 | |
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Appearance |
white powder |
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| Melting point | 240～241℃ | |
| PH |
1.0-1.4 (20°C, 100g/L in H2O) |
What are the uses of cocarboxylase?
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cocarboxylase is a white crystalline powder, which can be used in biochemical research; It is clinically used to treat arrhythmia, myocardial infarction, coma, etc |
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What are the physiological functions and functions of cocarboxylase?
Cocarboxylase is a metabolite of vitamin B1 and a cofactor synthesized in the cytosol. It is necessary to maintain the activities of cytosolic transketolase and mitochondrial pyruvate, ketoglutarate and branched chain ketate dehydrogenase. Cocarboxylase can be used to evaluate the mechanism of deacidification in biological systems. Cocarboxylase can also prevent hyperglycemia induced retinopathy and desflurane induced hepatotoxicity in rats.
Product Specification
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Items |
Specifications |
Results |
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Appearance |
white to off-white crystalline powder |
Conforms |
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Assay |
≥96% |
98.1% |
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Loss on Drying |
≤0.3% |
0.15% |
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Heavy metal |
≦20ppm |
10ppm |
Conclusion：Conform with specification and qualified.
what is the Reaction mechanisms of cocarboxylase?
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The carbanion of the cocarboxylase ylid nucleophilically attacks the carbonyl group on the substrate. (This forms a single bond between the TPP and the substrate.) The target bond on the substrate is broken, and its electrons are pushed towards the cocarboxylase. This creates a double bond between the substrate carbon and the cocarboxylase carbon and pushes the electrons in the N-C double bond in TPP entirely onto the nitrogen atom, reducing it from a positive to neutral form. In what is essentially the reverse of step two, the electrons push back in the opposite direction forming a new bond between the substrate carbon and another atom. (In the case of the decarboxylases, this creates a new carbon-hydrogen bond. In the case of transketolase, this attacks a new substrate molecule to form a new carbon-carbon bond.) In what is essentially the reverse of step one, the TPP-substrate bond is broken, reforming the TPP ylid and the substrate carbonyl.
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How and where to buy cocarboxylase?
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Transportation Time |
Shipping method |
Cargo weight requirements |
Advantage |
|
3-7 days |
DHL, Germany DHL, Germany DPD, |
Suitable for under 50kg. |
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7-15 days |
By Air |
Suitable for more than 50kg. |
|
|
15-60 days |
By Sea |
Suitable for more than 500kg. |
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Note: The product is for research use only and is not intended for diagnosis, treatment, disease prevention, etc.
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