Calcium L Threonate CAS 70753-61-6

What are the main uses of calcium l threonate?

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what is the Mechanism of action of calcium l threonate?

Once calcium l threonate dissociated to calcium and L-theronic acid, L-threonic acid exhibits significant stimulatory action on vitamin C uptake and prolongs the retention of vitamin C in human T-lymphoma cells  Vitamin C is a marker for osteoblast formation and has been shown to stimulate procollagen and enhance collagen synthesis  Via stimulation of vitamin C uptake, L-threonic acid acts as a metabolite that influences the mineralization process

Product Specification

Is calcium l threonate highly toxic?

Calcium L-threonate has low oral acute toxicity, with no adverse effects observed at doses as high as 40 g/kg bw in mice or 32 g/kg bw in rats, In a subchronic study of rats, the NOAEL of 4 g/kg bw/day was reported with the occurrence of reversible effects on blood coagulation and accretion of the thyroid gland.Studies in vitro and in vivo suggest that calcium L-threonate is unlikely to have genotoxic, carcinogenic, or mutagenic potential as L-threonate is an endogenous compound in the body . Reproductive and developmental toxicity studies in mice indicated that calcium L-threonate in doses up to 6 g/kg bw/day has no adverse effect on the fertility and the developing fetus, and did not cause maternal toxicity

how to produce calcium l threonate?

calcium l threonate is produced by a chemical reaction involving L-ascorbic acid, calcium carbonate, and hydrogen peroxide. This process typically involves dissolving L-ascorbic acid in water, slowly adding calcium carbonate, and then slowly adding hydrogen peroxide to the solution. The reaction is then typically heated and filtered, with activated carbon added to remove impurities. The filtrate is concentrated, crystallized, and then dried to obtain the final product.