What is 6 diazo 5 oxo l norleucine cancer ?
It is a yellow to orange crystalline powder with uniform and delicate texture, no caking and easy to absorb moisture. As an important amino acid analog, it is mainly prepared by chemical synthesis with high purity and few impurities, which meets strict quality control standards. It can effectively inhibit the activities of various glutamine-dependent metabolic enzymes, thus blocking the synthesis of nucleic acid and protein. Therefore, it is mainly used in the study of biochemical mechanism and the screening and evaluation of antitumor drugs. In the application field, it is widely used to explore metabolic pathways in cell experiments and as a key tool compound for the development of immunosuppressants or antibacterial agents.
Xi'an Faithful BioTech Co., Ltd. focuses on its R&D and production, and relies on strict quality control system to ensure the high purity and batch stability of products and realize the traceability of all links. Please contact us if you need to consult or order high quality 6 Diazo 5 Oxo L Norleucine Cancer.
| Product name |
6 diazo 5 oxo l norleucine cancer |
| CAS | 157-03-9 |
| Molecular formula | C6H9N3O3 |
| Molecular weight | 171.15 |
| EINECS Number | 251-228-4 |
| melting point | 145 °C |
| boiling point | 301.12°C (rough estimate) |
| density | 1.3994 (rough estimate) |
| refractive index | 1.5800 (estimate) |
| Storage condition | Room temperature preservation |
What are the main uses of 6 diazo 5 oxo l norleucine cancer?
6 diazo 5 oxo l norleucine cancer (DON for short) is an important glutamine antagonist
Its functions and applications are as follows:
First, the core role
Glutamine metabolism block
It inhibits glutamine metabolism, interferes with the energy supply of tumor cells, and does not affect the glutamine demand of normal cells, thus achieving selective anti-tumor effect.
Enzyme activity inhibition
As an amino acid mimetic, DON can inhibit the activities of many enzymes, including those involved in protein synthesis, and is often used in the study of protein and enzyme inhibitors.
Second, the main application areas
oncotherapy
Advantages of prodrug design DON
a new prodrug, is stable and inactive in normal tissues, and is only reduced to active form in hypoxic tumor environment, thus achieving selective tumor inhibition and reducing side effects on normal tissues. Other applications it can be used as an inhibitor of protein and enzyme and as an amino acid mimic in biochemical research and laboratory synthesis.
In hyperoxia (H22) liver cancer model, the glutamine blocking effect of DON was enhanced by 1.8 times, and the tumor inhibition rate reached 84.2%, and the body weight was not significantly affected. At present, it is in the clinical phase II research stage.
Treatment of inflammatory diseases
As a component of pharmaceutical composition, 6 diazo 5 oxo l norleucine cancer is used to treat or prevent inflammatory dermatoses, autoimmune diseases, etc., and plays a role by regulating immune response and inflammatory factor levels.
Product Specification
| Item | Specifications | Result |
|
Appearance |
Pale yellow powder | Complies |
| Assay | 88%~110.1% | 99.83% |
| Heavy Metal | ||
| Lead (Pb) | ≤2.0ppm | Complies |
| (As) | ≤1.0ppm | Complies |
| (Cd) | ≤1.0ppm | Complies |
| (Hg) | ≤0.1ppm | Complies |
| Microorganism | ||
| Total Plate Count | ≤1000cfu/g | Complies |
| Yeasts and Molds | ≤100cfu/g | Complies |
| Saimonella | Negative/25g | Complies |
| E.coli | Negative | Complies |
| Conclusion: The test results are conformed to the in-house specification | ||
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How and where to buy 6 diazo 5 oxo l norleucine cancer wholesale?
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Reasons for choosing us: reliable strength supply, high quality and stable storage, worry-free supply and timely delivery after sale.
A variety of shipping methods for you to choose
|
Transportation Time |
Shipping method |
Cargo weight requirements |
Advantage |
|
3-7 days |
DHL,Germany DHL,Germany DPD, |
Suitable for under 50kg. |
We have warehouses in Germany and California, USA, |
|
7-15 days |
By Air |
Suitable for more than 50kg. |
|
|
15-60 days |
By Sea |
Suitable for more than 500kg. |
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Attention: It should be noted that this product is not intended for the diagnosis, treatment, cure, or prevention of any disease. Please consult your doctor and learn about available research before use. Please do not use without authorization. This compound can only be used for research purposes. The US Food and Drug Administration has not evaluated these claims.
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