Tenoxicam Powder CAS 59804-37-4

what is Tenoxicam powder ?

Tenoxicam powder belongs to non steroidal anti-inflammatory drugs and is a long-acting antipyretic, analgesic, and anti-inflammatory drug. Used to treat diseases such as rheumatoid arthritis, rheumatic fever, and rheumatoid arthritis, it has significant effects such as rapid oral absorption and quick onset of action. Pain can be relieved within half an hour after administration, but long-term use can cause abdominal pain, nausea, indigestion, vomiting, and even damage to liver function.

	Product name	Tenoxicam
	CAS	59804-37-4
	Molecular formula	C13H11N3O4S2
	Molecular weight	337.37
	EINECS Number	620-500-8
	Storage condition	2-8°C
	Appearance	white to yellow to green powder
	Melting point	209-2130° C(dec)
	Density	1.4737(rough estimate)

What are the related studies on Tenoxicam powder?

(1) In vitro research

Tenoxicam(Ro-12-0068) is an on-steroidal anti-inflammatory drug (NSAID).
(2) In vivo research
Tenoxicam(Ro-12-0068) was administered in traperitoneally immediately after BCAO.Histological analyses show that ischemia produced significant striatal as well as hippocampal lesions which were reversed by the Tenoxicam(Ro-12-0068) treatment.Tenoxicam(Ro-12-0068) also significantly reduced,to control levels,the increased myeloperoxidase activity in hippocampus homogenates observed after ischemia.

What is the use of Tenoxicam powder?

Tenoxicam powder is an anti-inflammatory, antipyretic, and analgesic drug that has similar antipyretic, analgesic, and anti-inflammatory effects and uses as piroxicam. However, its efficacy is faster, its duration is longer, and it also has an inhibitory effect on platelet aggregation. It has a significant inhibitory effect on the release of lymphocytes, monocytes, and eosinophils, and can produce dual inhibition on cyclooxygenase and lipoxygenase. Quick onset, about 30 minutes to relieve pain, long-lasting, with a half-life of 70-90 hours, can be administered once a day. Used for rheumatoid arthritis, degenerative arthritis, ankylosing spondylitis, tendinitis, bursitis, shoulder or hip periarthritis, strain injury, sprain, acute gout, etc. Good tolerance.

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Product Specification

Items	Standards	Results
Character	Should be yellow crystalline powder	A yellow crystalline powder
Solubility	As stipulated	Conform
Identification	Conform to standard	Conform
Clarity of solution	As stipulated	Conform
Related substances	Impurity A≤0.15% Impurity B≤0.15 % Any unspecified Impurity≤0.1% Total Impurity≤0.3%	0.04% ND 0.01% 0.05%
Heavy metals	should be below 20ppm	Complies
Loss on drying	≤0.5%	0.13%
Ignition residue	≤0.1 %	0.09%
Assay test	99.0%～101.0%	99.5%

Conclusion：Conform with specification and qualified.

 

How to synthesize Tenoxicam powder?

3-Hydroxythiophene-2-carboxylic acid methyl ester is chlorinated to 3-chlorothiophene-2-carboxylic acid. The chlorine is nucleophilically substituted with sodium bisulfite and then methylated to form 3-sulfothiophene-2-carboxylic acid methyl ester (II). Chlorination converts the sulfonic group into sulfonyl chloride, followed by acylation of 2-methylaminoacetic acid ethyl ester. It is then cyclized under the action of sodium methoxide and finally reacted with 2-aminopyridine to form Tenoxicam Powder.

How and where to buy Tenoxicam powder wholesale?

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Transportation Time	Shipping method	Cargo weight requirements	Advantage
3-7 days	DHL, Germany DHL, Germany DPD, UPS, USPS,FedEx, TNT,EMS	Suitable for under 50kg. International door to door express	We have warehouses in Germany and California, USA, and customers in Europe and America can enjoy sending goods directly from these two places.
7-15 days	By Air	Suitable for more than 50kg. fast and cheaper for large order
15-60 days	By Sea	Suitable for more than 500kg. Cheapest shipping way

 

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Note: The product is for research use only and is not intended for diagnosis, treatment, disease prevention, etc.

 

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