Tazobactam sodium Introduction
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Tazobactam sodium appears as a white powder. Its CAS number is 89785-84-2. Molecular formula: C10H12N4NaO5S Molecular weight: 323.28 EINECS number: 685-629-4. Tazobactam Sodium Salt is a derivative of the Sulbactam class and belongs to irreversible β-lactamase inhibitors. Its structure is similar to Sulbactam pivoxil and Clavulanic acid, but it has a broader enzyme inhibition spectrum and higher stability. It is mainly applied in clinical settings.
What is the mechanism of action of Tazobactam sodium?
Tazobactam sodium is an irreversible β-lactamase inhibitor. The β-lactam ring within the molecule can be covalently linked to the active site of the β-lactamase secreted by bacteria, forming a stable complex structure, thereby permanently inactivating this type of hydrolase.
Bacteria rely on β-lactamases to break down Penicillin G and cephalosporin compounds, thereby developing resistance; Tazobactam Sodium Salt blocks the hydrolase function through this self-consuming binding. This substance itself has almost no antibacterial or bactericidal effect, but when used in combination with antibiotics, it can effectively protect the combined product and prevent it from being decomposed by various β-lactamases produced by resistant bacteria. Its inhibitory effect on ultra-extended-spectrum ESBL enzymes and some cephalosporin hydrolases is particularly prominent.
By this mechanism, Tazobactam sodium can restore the killing ability of Piperacillin and other PIERICIDIN A combinations against bacteria producing resistant enzymes, and the combination of these two components can form a significant antibacterial synergistic effect.
What is the use of Tazobactam sodium?
Tazobactam sodium is usually combined with other antibacterial ingredients to form a compound formulation. As a β-lactamase inhibitor component, it works synergistically to enhance efficacy. It is often combined with antibacterial ingredients like Piperacillin to address various moderate to severe bacterial infections.
The core function of Tazobactam Sodium Salt is to continuously inhibit the production of β-lactamase by pathogens. Through irreversible binding, it blocks the enzymatic decomposition process, ensuring that the combined antibacterial components are not damaged and reactivating the clearing effect of the raw materials on drug-resistant strains. The most widely used combination currently is the compound formulation of Piperacillin and Tazobactam sodium, which is mainly used for deep respiratory tract infections, abdominal inflammation, complex urinary and reproductive system inflammations, superficial soft tissue infections, systemic bacteremia, and also for antibacterial intervention in cases with low granulocyte counts accompanied by fever.
This combination can act on Gram-negative bacteria that can produce β-lactamase, including Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, and some anaerobic bacterial groups; however, it has no significant effect on MRSA, which does not develop resistance through enzyme production. This compound product belongs to a controlled prescription formulation and is only applicable to infected individuals who require standardized in-hospital treatment. It should be used rationally in accordance with the guidance of professional physicians.
MF of Tazobactam sodium
| CAS | 89785-84-2 |
| Molecular formula | C10H12N4NaO5S |
| Molecular weight | 323.28 |
| EINECS | 685-629-4 |
| Melting point | 140-147°C |
| Boiling point | 77℃ |
Specification
| Item | Specification | Result |
| Appearance | White powder | Complies |
| Loss on drying | ≤0.5% | 0.20% |
| Heavy metals | ≤20 ppm | Complies |
| Assay | ≥99.0% | 99.50% |
| Conclusion | Conform with enterprise specification | |
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| 7-15 days | By Air | Suitable for more than 50kg. fast and cheaper for large order |
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| 15-60 days | By Sea | Suitable for more than 500kg. Cheapest shipping way |
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FAQ:
Q1:What should be noted before using Tazobactam sodium?
It is necessary to confirm whether the patient has a history of allergy to Penicillin G, cephalosporins or β-lactamase inhibitors. Those who are allergic to the above products should not be used.
Q2:What are the common side effects of Tazobactam sodium?
The most common adverse reaction is diarrhea. Other relatively common ones include constipation, nausea, headache and insomnia.
Q3:Can pregnant women or lactating women use Tazobactam sodium?
Pregnant women should use it only with caution when necessary (the FDA classifies it as B grade; animal experiments did not show any risks but there is a lack of sufficient human research); breastfeeding women should stop breastfeeding when using this product, as Tazobactam sodium may be secreted through breast milk.
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