Ritlecitinib API CAS 1792180-81-4
Product Name:Ritlecitinib API
CAS.no:1792180-81-4
molecular formula:C15H19N5O
EINECS.NO:210-077-2
Synonym:EOS-61890;CS-2733;PF-06651600;PF 06651600;Ritlecitinib
Test Method:HPLC/UV
MOQ & Package: 10g,100g,1kg etc Sub-package
Certificate：FDA,ISO,COA, HPLC, MSDS,TDS etc
Lead Time: 1-3 days
Shipping: DHL,Germany DHL,Germany DPD,UPS,USPS,FedEx,EMS,By Air,By Sea etc
Store & Shelf life; Cool & dry place;36 months
Other:There are warehouses in the United States, Australia and Germany.
Description
What is Ritlecitinib?
Ritlecitinib API is an orally administered, highly selective dual inhibitor of Janus kinase 3 and members of the TEC kinase family. It modulates immune responses by precisely targeting inflammatory and autoimmune-related signaling pathways. Its greatest advantage is its significantly higher selective inhibitory activity against JAK3 compared to JAK1/2, while inhibition of TEC kinases helps eliminate pathogenic T cells. Ritlecitinib was approved in the United States, Japan, and other countries in 2023 and has been included in the priority review process in China. Currently, it is primarily used for severe alopecia areata in adolescents aged 12 and older and adults. Furthermore, research on its use in other immune-mediated diseases such as vitiligo and ulcerative colitis is also underway.
contact us by Email ：sales6@faithfulbio.com
What is the purpose of Ritlecitinib?
Ritlecitinib can help people who have lost a lot of hair due to this autoimmune disease to regrow their hair. It is primarily used to treat alopecia areata, a condition where the immune system attacks hair follicles, causing patchy hair loss. The Ritlecitinib API product is specifically approved for adults and adolescents aged 12 and older with severe alopecia areata. This includes people with total or diffuse alopecia.
What is the mechanism of action of ritilecitinib?
The primary mechanism of action of Ritlecitinib involves the inhibition of Janus kinases. Janus kinases are enzymes that play a crucial role in the immune system, particularly in signal transduction. The immune system uses Janus kinases to transmit information and regulate the activity of immune cells. In autoimmune diseases, the immune system mistakenly attacks and damages the body's own tissues, leading to inflammation and tissue damage. By inhibiting Janus kinases, the Ritlecitinib API can interfere with the abnormal activity of the immune system, reducing inflammation in the immune response and potentially alleviating symptoms caused by autoimmune diseases. This mechanism of action makes Ritlecitinib a potential treatment for autoimmune diseases.
MF of Ritlecitinib
| Density | 1.272±0.06 g/cm3 |
| Water solubility | H2O: 5mg/mL, clear (warmed) |
| Acidity coefficient | 13.03±0.50 |
| Molecular formula | C15H19N5O |
| EINECS | 210-077-2 |
Specification
| Item | Specification | Results |
| Appearance | White to off-white powder | Complies |
| Identification | The sample spectrum conforms to thereference spectrum | Complies |
| Assay | 98.0% - 102.0% | 99.60% |
| Loss on Drying | ≤0.5% | 0.18% |
| Residue on Ignition | ≤0.1% | 0.04% |
| Sulfated Ash | ≤0.1% | 0.05% |
| Related Substance | Individual impurity ≤0.5% | 0.25% |
| Total impurities ≤1.0% | 0.43% | |
| Heavy Metals | ≤ 20 ppm | <10ppm |
| Conclusion | Conform with enterprise specification | |
A variety of shipping methods for you to choose
|
Transportation Time |
Shipping method |
Cargo weight requirements |
Advantage |
|
3-7 days |
DHL,Germany DHL,Germany DPD, |
Suitable for under 50kg. |
We have warehouses in Germany and California, USA, |
|
7-15 days |
By Air |
Suitable for more than 50kg. |
|
|
15-60 days |
By Sea |
Suitable for more than 500kg. |
Our strengths:
Our company has passed FDA and ISO19001 quality management system certification. And we have internal cooperation agreements with multiple factories and laboratories in China,Our company can provide Ritlecitinib API etc. at a more favorable price. If you are interested, please leave a message.
We not only have unique advantages in transportation, but also support multiple payment methods, whether you use US dollars, euros, Australian dollars, or local currencies from Singapore, Malaysia, Thailand, and so on. We can also support local currencies in these regions and countries. In addition, we also support bank cards (credit cards, etc.) for payments.
FAQ:
Q1: What are the side effects of Ritlecitinib?
Common side effects experienced by many people include headaches, diarrhea, and cold or flu-like symptoms. These are usually mild and typically improve as your body adjusts to the product in the first few weeks.
Q2: How long should Ritlecitinib be used?
Ritlecitinib is a product that needs to be taken continuously for a long period of time, not in a fixed course. Optimal efficacy is usually achieved between 48 weeks and 24 months, and the specific duration of use should be determined by a doctor based on individual efficacy and tolerability.
Q3:Who cannot use Ritlecitinib?
Ritlecitinib API is not recommended for use in patients with hypersensitivity to any component, active severe infections, severe liver damage, pregnant or breastfeeding women, or children under 12 years of age.
Disclaimer: The information published on this website comes from the internet, which does not mean that this website agrees with its views or confirms the authenticity of the content. Please pay attention to distinguish it. In addition, the products provided by our company are only used for scientific research. We are not responsible for the consequences of any improper use.
If you are interested in our products, or have critical suggestions on our articles or are not completely satisfied with the products received, please contact us by Email ：sales6@faithfulbio.com . Our team is committed to ensuring the complete satisfaction of customers.
Hot Tags: ritlecitinib api cas 1792180-81-4, China, suppliers, manufacturers, factory, customized, wholesale, buy, price, bulk, pure, producer, discount, for sale, in stock, free sample, raw powder, raw material, made in China
Send Inquiry
You Might Also Like
