Product description
Oxolinic acid raw powder is a synthetic quinolone antibiotic primarily used in veterinary medicine, particularly in aquaculture, and sometimes in human medicine for urinary tract infections. It is effective against both Gram-negative and Gram-positive bacteria, though it is more commonly used for its Gram-negative activity. Oxolinic acid works by inhibiting DNA gyrase, an enzyme essential for DNA synthesis.
It is used in veterinary medicine for the treatment of bacterial infections in cattle, pigs and poultry. It has a role as an antiinfective agent, an antibacterial drug, an enzyme inhibitor, an antimicrobial agent and an antifungal agent.
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COA
| ltems | Standard | Results |
| Appearance | White or off-white crystal | Complies |
| Identification | By IR | Complies |
| ByHPLC | Complies | |
| Water Content | ≤0.50% | 0.01% |
| Loss on drying | ≤0.5% | 0.01% |
| Total impurities | ≤2.0% | 0.01% |
| Heavy Metals | ≤20ppm | Complies |
| Residual solvents Ethanol |
≤0.5% | 0.05% |
| Residue on Ignition | ≤0.20% | 0.01% |
| Related Substance | Any single impurity:≤0.10% | 0.05% |
| Total Impurities:≤1.00% | 0.05% | |
| Assay | 98.0%~102.0% | 99.99% |
| Microbiology | ||
| Total Plate Count | <1000cfu/g | Complies |
| Yeast &Moulds | <100cfu/g | Complies |
| E.Coli | Negative | Complies |
| Salmonella | Negative | Complies |
| Conclusion | Conform with enterprise specification | |
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Density: 1.5±0.1 g/cm ³
Boiling point: 473.2±45.0 °C at 760 mmHg
Melting point: 314-316°C (dec.)
Molecular formula: C13H11NO5
Molecular weight: 261.230
Flash point: 240.0±28.7 °C
Precise mass: 261.063721
PSA 77.76000
LogP 1.43
What is Oxolinic acid raw powder in fish?
Oxolinic acid (OA), a first-generation fluoroquinolone antibiotic, has proven effective in managing bacterial diseases in tilapia aquaculture, particularly those caused by pathogens like A. hydrophila and E.
What is the function of Oxolinic acid raw powder?
Oxolinic acid raw powder is a synthetic antimicrobial agent which is similar in structure to the naturally occurring nalidixic acid, but is more active against both Gram-negative and Gram-positive bacteria although it is used almost exclusively for its Gram-negative microbiological activity.
What is the mechanism of action of Oxolinic acid raw powder?
Their mode of action is by the inhibition of bacterial DNA-gyrase (topoisomerase II), which is responsible for maintaining the topography of DNA. The action is primarily on the bacterial DNA-gyrase with insignificant inhibition of the corresponding mammalian enzyme.
The main uses and properties of Oxolinic acid raw powder
Veterinary Medicine:
Oxolinic acid is authorized for use in fin fish, calves, pigs, and poultry. It is often administered through feed, drinking water, or as a bolus.
Human Medicine:
While historically used for urinary tract infections, other treatments are often preferred due to better bioavailability and fewer side effects.
Aquaculture:
Oxolinic acid is a widely used drug in aquaculture due to its low cost, low toxicity to fish, and satisfactory performance.
Antimicrobial Activity:
It is effective against a range of Gram-negative bacteria, including Proteus species, but less active against Pseudomonas. It is also active against some Gram-positive bacteria, including staphylococci.
Mechanism of Action:
Oxolinic acid inhibits DNA gyrase, an enzyme responsible for DNA synthesis and replication. This action prevents bacterial growth and reproduction.
Photosensitization:
Oxolinic acid raw powder is associated with photosensitization reactions and can induce photosensitized hemolysis of erythrocytes.
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why choose us
Our Factory
Package
Shipping Methods
|
Transportation Time |
Shipping method |
Cargo weight requirements |
Advantage |
|
3-7 days |
DHL,Germany DHL,Germany DPD, |
Suitable for under 50kg. |
We have warehouses in Germany and California, USA, and customers in Europe and America can enjoy sending goods directly from these two places. |
|
7-15 days |
By Air |
Suitable for more than 50kg. |
|
|
15-60 days |
By Sea |
Suitable for more than 500kg. |
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