What is Canagliflozin?
Canagliflozin is a selective SGLT2 inhibitor, which acts on CHO cells expressing mSGLT2, rSGLT2 and hSGLT2 with IC50 of 2 nM, 3.7 nM and 4.4 nM, respectively. Canagliflozin is a chemical substance, and Canagliflozin powder is a white to white powder with poor stability, which needs to be stored in a dry, dark and cool place.
| Product name | Canagliflozin |
| CAS | 842133-18-0 |
| Molecular formula | C24H25FO5S |
| Molecular weight | 444.52 |
| EINECS Number | 695-192-1 |
| Storage condition | -20°C |
| Melting point | 68 - 72°C |
| Solubility | Dissolved in DMSO (40 mg/ml) |
| Appearance | White powder |
| Boiling point | 642.9±55.0 °C(Predicted) |
| Density | 1.364 |
How does Canagliflozin work?
Product Specification
| Item | Specification | Results |
| Characteristics | White or off-white crystalline powder | Complies |
| Identification | By IR | Complies |
| By HPLC | Complies | |
| Melting Point | 95ºC~105ºC | 101ºC~102ºC |
| Water Content | 2.0%~3.0% | 2.50% |
| Heavy Metals | ≤ 20ppm | Complies |
| Residue on Ignition | ≤ 0.10% | 0.06% |
| Isomer | ≤ 0.15% | ND |
| Related Substances | Any single impurity: ≤0.20% | 0.06% |
| Total Impurities: ≤0.50% | 0.16% | |
| Purity(HPLC) | ≥ 99.50% | 99.84% |
| Reference Standard | In-house Standard | |
What are the uses of Canagliflozin?
First, hypoglycemic effect
1. Inhibition of sodium-glucose cotransporter (SGLT)：Canagliflozin can not only improve insulin resistance by inhibiting renal SGLT2, but also partially reduce postprandial blood glucose increase by inhibiting SGLT1 to delay intestinal glucose absorption, which has dual effects of α -glucosidase inhibitor and renal mechanism.
2. Improve islet function: Canagliflozin powder can increase serum adiponectin level, reduce visceral adipose tissue and ectopic fat accumulation, thus reducing insulin resistance.
3. Proliferation of β-cells: The density of parasympathetic nerve (PN) and nerve fiber density in epidermis increased after the use of Canagliflozin, which improved the loss of unmyelinated fibrils in the early stage of DPN, thus increasing Vβ.
Second, weight loss and lipid-lowering effect:
The early decline of body mass is caused by liquid excretion caused by the natrium-promoting effect of Canagliflozin, and the late decline of body mass is caused by the decrease of calories and the resulting decrease of fat mass.
Third, the antihypertensive effect
Under the condition of hyperglycemia (HG), excessive glucose enters proximal renal tubular cells (PTC) through SGLT2, which stimulates the production of renal angiotensinogen (AGT), activates renal renin-angiotensin system (RAS), increases the level of renal angiotensin II, and causes sodium retention and arterial pressure increase. Canagliflozin can inhibit the kidney by blocking SGLT2 to reduce the production of ROS in PTC and increase the expression of renal AGT.
Fourth, reduce uric acid
Canagliflozin can significantly reduce serum uric acid level and reduce the risk of first-episode and recurrent gout adverse events by half.
V. Cardiovascular protection
Studies have shown that Canagliflozin can significantly reduce the risk of major cardiovascular adverse events (cardiovascular death, nonfatal myocardial infarction or nonfatal stroke). Some research results also suggest that Canagliflozin has primary and secondary preventive effects on cardiovascular diseases.
HTML5 atlas of Canagliflozin
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Is canagliflozin the same as metformin?
There are great differences between Canagliflozin and metformin in hypoglycemic mechanism. Canagliflozin belongs to sodium glucose cotransporter 2 inhibitor. Mainly by lowering the renal glucose threshold, reducing the reabsorption of glucose by the kidney, and increasing the excretion of glucose from urine, thus playing a role in lowering blood sugar. Metformin mainly reduces blood sugar by inhibiting the source of glucose and increasing glucose. In addition, metformin can also improve insulin sensitivity. The two drugs mentioned above are hypoglycemic drugs, so it is recommended to use them under the guidance of a doctor, and never use them by yourself.
What is the side effect of canagliflozin?
The side effects of long-term use of Canagliflozin include allergic reaction, urinary tract infection, genital infection, hypoglycemia, kidney problems, etc. The specific analysis is as follows:
1. allergic reaction
Long-term use of Canagliflozin may cause blistering and peeling of the skin, and even dysphagia, which is a common allergic reaction.
2. Urinary tract infection
When using Canagliflozin, there may be problems of urinary tract infection, such as hematuria and pain when urinating.
3. Period infection
During the use, vaginal itching and abnormal secretion of secretions may occur, and men may have penis pain and swelling, which is a side effect of genital infection.
4. Hypoglycemia
Canagliflozin is a hypoglycemic drug. If it is not used correctly, it may cause hypoglycemia in patients, mainly manifested by dizziness and rapid heartbeat.
5. Kidney problems
There may also be kidney diseases during use, such as inability to urinate and changes in urine output.
How and where to buy Canagliflozin Powder wholesale?
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Note: This compound should be used for research purposes only. These claims have not been evaluated by the Food and Drug Administration. Please consult your doctor and learn about available studies before using them. This product is not intended to diagnose, treat, cure, or prevent any disease.
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