Inosine powder is a white needle shaped crystal with no odor and a slightly bitter taste. Slightly soluble in water, insoluble in chloroform and ethanol, and easily soluble in alkaline solutions such as dilute hydrochloric acid or sodium hydroxide. The saturated aqueous solution of this product contains approximately 1.5% inosine. Pure inosine is a nucleoside compound formed by the binding of hypoxanthine and ribose. In the de novo synthesis of purines, inosine monophosphate (IMP) can serve as a precursor for the synthesis of adenosine monophosphate (AMP) and guanosine monophosphate (GMP).
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Inspection |
Standard |
Test Results |
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Appearance |
White crystalline powder |
White crystalline powder |
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Identification |
Positive In No.1 ,2,3 test |
Conforms |
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State of solution transmittance |
Clear and colorelss not less than 98.0% |
99.5% |
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Assay(on dried product) |
98.0-102.0% |
99.7% |
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Loss on drying |
≤1.0% |
0.18% |
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Heavy metal(Pb) |
≤10ppm |
＜10ppm |
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Residue on ignition |
≤0.2% |
0.02% |
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Other related compounds of nucleic Acid |
Chromatographically not detectable |
Conforms |
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Arsenic(As2O3) |
≤1ppm |
＜1ppm |
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PH |
4.8-5.8 |
5.2 |
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Microbial Limit |
1. Total plate count:≤1000cfu/g 2. Mold&Yeast:≤100cfu/g 3. E.Coli:Negative |
Conforms Conforms Conforms |
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Conclusion |
The result conforms to the enterprise standard as above FOR LABORATORY USE ONLY |
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What are the important functions of inosine in tumor immunotherapy?
Inosine powder is an endogenous metabolite of human body, and also widely exists in many traditional Chinese medicines, such as Pheretima, Cordyceps sinensis, Pinellia ternata, etc., and pure inosine is a conventional adjuvant medicine for treating chronic hepatitis in clinic, which shows that pure inosine has good clinical safety. Recently, some researchers found that inosine and its derivative, inosine, can increase the immunogenicity of tumor cells by inhibiting the activity of UBA6, thus improving the tumor immunotherapy response. It has also been proved in animal tumor model that inosine and its derivative, inosine, can significantly improve the therapeutic effect of ICB, and this is consistent with the change of inosine in clinical tumor patient samples. However, this not only provides a new drug target for tumor immunotherapy in clinic, but also provides a theoretical basis for the combination of inosine, isopropylidene and Chinese patent medicine containing inosine with immune checkpoint blockers, and does not solve the problem that a large amount of inosine is used to be decomposed into guanine, adenine, ATP, etc., and cannot effectively inhibit tumor cells.
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| 58-63-9 Inosine | Inosine can resist both sugar and oxygen! |
What are the biological activities and uses of inosine?
Inosine is a key intermediate product in purine metabolism,it is an atypical nucleotide that mainly exists in the form of monophosphate. It has the ability to pair with deoxythymine, deoxyadenosine, and deoxyguanosine base pairs. Capable of pairing with deoxythymine, deoxyadenosine, and deoxyguanosine base pairs.add pure Inosine powder with antioxidant, anti-inflammatory, and neuroprotective functions. The nutritional supplements we often use contain inosine components. It regulates biological processes through adenosine receptors for the repair of nerve damage, alleviation of inflammation and oxidative stress symptoms. In addition,pure inosine powder is also used to treat sepsis in infections or it can promote the growth of depressive neural processes through adenosine receptors.
Inosine is an effective stimulating factor for nerve growth factor (NGF), which can induce neurite outgrowth. In animal model experiments, administering a certain amount of pure inosine to mice with ischemic brain injury restored their fine motor control ability to normal. Researchers speculate that the increase in inosine levels is associated with an increase in expressed proteins related to axonal regeneration and growth.
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Transportation Time |
Shipping method |
Cargo weight requirements |
Advantage |
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3-7 days |
DHL,Germany DHL,Germany DPD, |
Suitable for under 50kg. |
We have warehouses in Germany and California, USA, |
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7-15 days |
By Air |
Suitable for more than 50kg. |
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15-60 days |
By Sea |
Suitable for more than 500kg. |
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