Formoterol Fumarate Dihydrate API CAS 183814-30-4

What is Formoterol fumarate dihydrate ?

Formoterol hemifumarate hydrate is not only a selective, long-acting β2-adrenergic receptor agonist, but also a long-acting bronchodilator used in research on asthma and chronic obstructive pulmonary disease . It relaxes the muscles surrounding the airways, allowing the respiratory tract to reopen. Its most notable feature is its "dual effect": rapid onset and long-lasting efficacy. Formoterol fumarate dihydrate API can also induce mitochondrial biogeneration after brain injury and promote cognitive recovery.

Therefore, it can be used for routine maintenance therapy and, under a doctor's guidance, for the prevention of exercise-induced dyspnea.

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What is the mechanism of action of Formoterol fumarate dihydrate?

Formoterol fumarate dihydrate mainly acts precisely on the specific receptors on the airway muscles, initiating the normal signal transmission process within the body. When the component binds to the receptor, it will promote the transformation of related substances within the body, activate the active substances, gradually reduce the calcium ion content in the airway cells, allowing the tense airway muscles to slowly relax, smoothly opening the airway, and easily alleviating breathing difficulties.
This raw material has strong lipid solubility and can adhere and remain on the airway cell membrane for slow release. It can take effect quickly within just a few minutes after inhalation and can also provide a stable effect for up to twelve hours after a single use. It takes into account both fast and slow effects.
In the conventional dosage, it mainly aims to dilate and clear the airway, is unlikely to cause the body to develop resistance, and the drug effect can also be stably maintained over a long period of use. In addition, it can regulate multiple physiological pathways within the body, assist in normal cell metabolism, and reduce the release of inflammatory substances in the body. It not only simply clears the airway but also has multiple functions such as soothing and regulating, and repairing the respiratory tract condition.
Overall, it relies on precise targeting, long-acting sustained-release characteristics, mild and low tolerance features, as well as multiple effects such as auxiliary anti-inflammatory and repair, to form a comprehensive and stable respiratory tract conditioning effect system.

Why does Formoterol fumarate dihydrate work fast and last long?

Formoterol fumarate (100 mg) achieves both rapid onset and long-lasting action primarily because its molecular structure strikes an optimal balance between hydrophilicity and lipophilicity. Its rapid onset is due to its superior hydrophilicity; unlike strongly lipophilic products that must first diffuse laterally into the membrane, Formoterol fumarate dihydrate API diffuses rapidly directly from the aqueous phase of the airway after inhalation, binding to the orthotropic binding sites of β2 receptors on the cell membrane surface, thus avoiding delayed onset. Its long duration of action is due to its good lipophilicity: its molecules can temporarily remain in the lipid layer of airway muscle cells, forming storage sites, and then be slowly released to continuously act on the target site; moreover, its slow dissociation after binding to the receptor allows for a longer duration of action with each binding. This delicate balance between hydrophilicity and lipophilicity makes formoterol fumarate dihydrate the only single-acting, long-lasting β2 agonist currently available that combines the rapid onset and sustained-release properties of an emergency medication.

MF of Calcium glycerophosphate

Molecular weight	460.48
Melting point	116-120°C
Solubility	DMSO: soluble, 20 mg/mL
Flash point	318.6°C

Specification

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FAQ:

Q1: What are the advantages of Formoterol fumarate dihydrate's "dual-effect" combination?
Its most distinctive feature is its "dual-effect combination": it takes effect very quickly, working within 1-3 minutes of inhalation, while also providing long-lasting effects, with a single application lasting up to 12 hours.
Q2: Can Formoterol fumarate dihydrate be used alone for long-term treatment of asthma?
Asthma patients should not use Formoterol Fumarate (100 mg) alone, as it can easily worsen their condition and carries extremely high risks. COPD patients can use it alone for maintenance and management under the guidance of a doctor.
Q3: What are some common adverse reactions that may occur after using Formoterol fumarate dihydrate?

Common adverse reactions to Formoterol fumarate dihydrate API include dry mouth, palpitations, tremors (especially in the hands), and headache. These reactions are related to β2 receptor agonism and are usually more pronounced in the early stages. Most patients can tolerate them over time, but if severe palpitations occur, medical attention should be sought immediately.

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