What is Ethyl nicotinate?
Ethyl nicotinate is an important basic chemical raw material, which is widely used in the synthesis of medicine and pesticides. Ethyl nicotinate is a colorless to yellowish liquid with a special smell. It is insoluble in water, but soluble in many organic solvents, such as ethanol, ether, chloroform and so on. It is an unstable compound, so attention should be paid to the possibility of its degradation during storage and handling.
| Product name | Ethyl nicotinate |
| CAS | 614-18-6 |
| Molecular formula | C8H9NO2 |
| Molecular weight | 151.16 |
| EINECS Number | 210-370-7 |
| Storage condition | Store below +30°C. |
| Melting point | 8-10 °C (lit.) |
| Solubility | 50 g/l |
| Appearance | Pale yellow liquid |
| Boiling point | 223-224 °C (lit.) |
| Density | 1.107 g/mL at 25 °C (lit.) |
Preparation method of ethyl nicotinate:
CN106957262A discloses a preparation method of ethyl nicotinate, which is characterized in that nicotinic acid, anhydrous ethanol and solid acid catalyst for esterification reaction are added into toluene, stirred and reacted at 50-65 DEG C for 3-6 hours, then heated and refluxed for water separation, and after the anhydrous separation reaction is finished, the temperature is lowered to room temperature, the solid acid catalyst for esterification reaction is recovered by filtration, and toluene is recovered from the filtrate under reduced pressure, and the light yellow transparent liquid is the finished product ethyl nicotinate; The molar ratio of nicotinic acid to anhydrous ethanol is 1: 1-1: 2, the weight ratio of nicotinic acid to toluene is 1: 0.3-1: 8, and the addition amount of solid acid catalyst for esterification reaction is 0.01-0.1 times of the weight of nicotinic acid; The solid acid catalyst for esterification reaction is HND230 solid catalyst.
The invention has the advantages of reducing the generation of highly polluted wastewater, reducing labor and equipment costs and being suitable for large-scale industrial production.
Product Specification
| Item | Specification | Results |
| Appearance | Colorless or light yellow transparent liquid | Conforms |
| Content | ≥99% | 99.55% |
| Water | ≤0.1% | 0.1% |
| Conclusion: | Conform with enterprise specification. | |
What is the application of ethyl nicotinate?
1. Ethyl nicotinate is mainly used in pharmaceutical industry as an intermediate for synthesizing vitamin B3 (nicotinic acid).
2. Used in organic synthesis
3. Ethyl nicotinate is a carboxylate derivative, which is widely used in the synthesis of medicine and pesticides as an important basic chemical raw material.
HTML5 atlas of Ethyl nicotinate
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1HNMR Of Ethyl Nicotinate
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What should we pay attention to when using Ethyl nicotinate?
1. Ethyl nicotinate is a chemical, please strictly abide by the relevant safety operation procedures.
2. When contacting ethyl nicotinate, avoid inhaling its vapor and avoid contact between skin and eyes.
3. In case of accidental contact, immediately flush the affected area with plenty of clean water and seek medical treatment.
4. Ethyl nicotinate should be stored in a cool, dry and well-ventilated place to avoid contact with combustibles and oxidants.
How and where to buy Ethyl nicotinate wholesale?
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Note: This compound should be used for research purposes only. These claims have not been evaluated by the Food and Drug Administration. Please consult your doctor and learn about available studies before using them. This product is not intended to diagnose, treat, cure, or prevent any disease.
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