Econazole nitrate powder is a white or slightly yellow crystalline substance, odorless, and a broad-spectrum antifungal product. Pure econazole nitrate is a dechlorinated derivative of miconazole. Its mechanism of action is to inhibit the synthesis of fungal cell membranes to affect their metabolic processes. It has antibacterial activity against Candida, Chromogenic Fungi, Sphingosporum, Histoplasma, Spodoptera, and other fungi, as well as against Trichophyton. It has poor effects on Aspergillus, Burkholderia sporogenes, certain dark spore families, and the genus Mucor.
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Item |
Standard |
Test Results |
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Appearance |
White crystalline solid |
Conform |
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Identification |
IR |
Conformed |
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UV |
Conformed |
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An intense blue color develops |
Conformed |
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Melting range |
162℃-166℃ |
165℃-166℃ |
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Chromatographic purity |
Single impurity: ≤0.375% |
0.13% |
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Total impurity: ≤2.0% |
0.24% |
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Residual solvents |
Toluene: ≤0.089% |
0.03% |
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Isopropanol：≤0.089% |
Undetected |
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Residue on ignition |
≤0.1% |
0.07% |
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Loss on drying |
≤0.5% |
0.22% |
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Assay |
98.5%-101.0% |
99.2% |
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E.coli |
Negative/25g |
Conform |
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Staphyloccocus aureus |
Negative/25g |
Conform |
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P.aeruginosa |
Negative/25g |
Conform |
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Total Yeast and Mold Count |
≤10 CFU/g |
Conform |
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Total Viable Aerobic Count |
≤100 CFU/g |
0.32 CFU/g |
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Conclusion: |
Up to the standard of USP34 |
Which is better, econazole nitrate or terbinafine hydrochloride?
Both econazole nitrate and terbinafine hydrochloride are drugs used to treat fungal diseases. econazole nitrate is a metronidazole antifungal drug that can selectively interfere with fungal activity, thereby inhibiting the biosynthesis of ergosterol on fungal cell membranes.
There are many external dosage forms of econazole nitrate, such as econazole nitrate solution, econazole nitrate spray, econazole nitrate cream, etc. The indication is for the treatment of Candida albicans in the skin, and it can also be used to treat tinea corporis, tinea pedis, tinea pedis, and tinea versicolor. Adverse reactions include local burning sensation, occasional itching, rash and other allergic reactions.
Terbinafine is an acrylic amine drug with broad-spectrum antifungal activity. This product can specifically interfere with the early biology and synthesis of fungal sterols, selectively inhibit the fungal ergosterol cyclooxygenase, and block the ergosterol epoxidation reaction during fungal cell membrane formation, thereby achieving the effect of killing or inhibiting fungi.
This product is suitable for infections of the skin, scalp, and nails caused by various types of dermatophytes, spore forming fungi, and flocculent epidermal fungi. Various ringworm diseases, including tinea corporis, tinea pedis, tinea pedis, and tinea capitis, as well as skin yeast infections caused by Candida, and onychomycosis caused by pathogenic fungi. Commonly used dosage forms include tablets, creams, gel and sprays, which should be banned if they are allergic to Terbinafine.
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| 24169-02-6 Econazole nitrate | 91161-71-6 Terbinafine | 22832-87-7 Miconazole nitrate |
Our company can provide various Miconazole nitrate,Terbinafine,Econazole nitrate etc. If you are interested, please contact us via email:sales6@faithfulbio.com
What is the difference between miconazole and econazole?
Miconazole and Econazole are both products used clinically to treat fungal infections, and many fungi belong to the jointly effective part of both. Due to overlapping drug effects, it is usually not recommended to use them together. To avoid using excessive doses that may cause overlapping drug effects, increase skin irritation, burden the skin, and affect skin recovery. Or induce fungal resistance, or increase the risk of secondary infection, etc. However, there are usually subtle differences between the two in terms of composition, appearance, and function.
1. Different ingredients: the main ingredient of miconazole is miconazole nitrate; The main component of econazole is econazole nitrate.
2. Different appearance: Miconazole is white powder and odorless; The appearance of econazole is white or white-like crystals.
3. Different effects: Miconazole can inhibit the synthesis of fungal cell membrane, thus affecting the metabolism of some cells in human body. It has antibacterial effect on candida in clinic, and is suitable for skin infection caused by dermatophytes and yeasts. By interfering with the activity of cytochrome P-450, econazole inhibits the biosynthesis of ergosterol, the main sterol in fungal cell membrane, which can lead to cell ultrastructure degeneration and cell necrosis.
What is the difference between Econazole and Ketoconazole?
Ketoconazole generally refers to ketoconazole cream. In general, the difference between econazole cream and ketoconazole cream lies in their different ingredients, different treatments for diseases, different effects and uses, and different side effects.
1. Different components
The main ingredient of Yikangzuo cream is ketoconazole, which also contains chlorhexidine propionate, neomycin sulfate, glycerol monostearate and other ingredients. The main component of ketoconazole cream is ketoconazole, which also contains testosterone undecanoate, stearic acid, glycerides, and other ingredients.
2. Treating different diseases
Yikangzuo cream can generally be used to treat fungal infections caused by skin ringworm, such as tinea manus, tinea pedis, tinea corporis, etc. Ketoconazole cream can generally be used to treat diseases caused by fungal infections, such as tinea versicolor, tinea pedis, tinea pedis, tinea corporis, tinea pedis, tinea pedis, tinea pedis, tinea pedis, tinea versicolor, and candidiasis. However, it is usually replaceable in clinical use.
3. Different effects and uses: Yikangzuo is a broad-spectrum antifungal drug that can be used to treat various fungal infections, including Candida (such as oral candidiasis, vaginal candidiasis) and Trichophyton, as well as respiratory fungal infections, skin fungal infections, nail fungal infections, etc. Ketoconazole also has broad-spectrum antifungal effects, but is mainly used to treat fungal infections on the skin and scalp. However, the focus of their efficacy is also different. Yikangzuo focuses more on dermatitis and eczema with a tendency towards fungal infections, while ketoconazole focuses more on reducing the risk of early recurrence. At the same time, it also has strong anti allergic and anti-inflammatory effects, which can reduce vascular permeability.
4. Different side effects
Some patients may experience discomfort symptoms such as skin burning and itching after using Yikangzuo cream, as well as nausea, vomiting, abdominal pain, diarrhea, and other discomfort symptoms. Ketoconazole cream may have side effects such as dry skin, redness, and flaking after use, as well as side effects such as blurred vision and fatigue.
Detailed explanation of pharmacological action of econazole nitrate
econazole nitrate powder inhibits the biosynthesis of ergosterol, the main sterol in fungal cell membranes, by interfering with the 14- α - demethylase dependent on cytochrome P-450. It damages the fungal cell membrane and changes its permeability, causing important intracellular substances to leak out. It can also inhibit the synthesis of ribonucleic acid, as well as the biosynthesis of triglycerides and phospholipids in fungi. It can also inhibit the activity of oxidase and peroxidase, causing the accumulation of hydrogen peroxide in cells, leading to microstructural degeneration and cell necrosis, thereby affecting metabolism, preventing bacterial cell development and cell death, and achieving antibacterial and bactericidal effects. Candida albicans can inhibit its transformation from spore to invasive hyphae. It is a widely used antifungal drug in clinical practice.
A variety of shipping methods for you to choose
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Transportation Time |
Shipping method |
Cargo weight requirements |
Advantage |
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3-7 days |
DHL,Germany DHL,Germany DPD, |
Suitable for under 50kg. |
We have warehouses in Germany and California, USA, |
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7-15 days |
By Air |
Suitable for more than 50kg. |
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15-60 days |
By Sea |
Suitable for more than 500kg. |
Our strengths:
Our company has passed FDA and ISO19001 quality management system certification. And we have internal cooperation agreements with multiple factories and laboratories in China,Can provide you with a good price.Our company can provide miconazole, terbinafine, econazole, ketoconazole, and certain pure ingredients such as testosterone undecanoate powder. If you are interested, please contact us
We not only have unique advantages in transportation, but also support multiple payment methods, whether you use US dollars, euros, Australian dollars, or local currencies from Singapore, Malaysia, Thailand, and so on. We can also support local currencies in these regions and countries. In addition, we also support bank cards (credit cards, etc.) for payments.
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