Dexmedetomidine HCL CAS 145108-58-3

Dexmedetomidine HCL is the only sedative raw material that can wake up patients during surgery. It has certain anti-anxiety, analgesic and diuretic effects, and has the advantages of low respiratory inhibition, low delirium and protection of heart/kidney/brain. It is mainly used as an anesthetic adjuvant for short-term sedation during mechanical ventilation in various surgical operations and intensive care patients, and sometimes it is used for the treatment and relief of some painful diseases because of its excellent analgesic function.

Product Specification

What are the two kinds of adrenergic receptors?

There are receptors that react with adrenaline and norepinephrine in various organs that are innervated by sympathetic postganglionic fibers, which are called adrenoceptors. They can be divided into α-type and β-type by different methods of responding to agonists. Dexmedetomidine HCl we are talking about is an effective and highly selective α-2 adrenoceptor agonist, which is different from α-1 adrenoceptor agonist. It can effectively lower blood pressure and relieve people's tension. Especially remarkable sedation ability, so as to reduce the frequency of using anesthetic products for patients.
We know that when people are nervous, anxious or stressed, the presynaptic membrane will release a lot of catecholamine substances. α2 exists in the presynaptic membrane of nerve synapse, which stimulates α2 receptor, which can inhibit the release of catecholamine from the presynaptic membrane and make the vital signs of patients tend to be stable.

Besides Dexmedetomidine, what other products are there for α2 receptor agonists?

A typical α 2 receptor agonist in clinic is dexmedetomidine hydrochloride. In addition, there are clonidine hydrochloride, atropine, lidocaine and so on.
1.clonidine hydrochloride
Clonidine hydrochloride can be used as a typical α2 adrenergic receptor agonist, which can relax blood vessels and make blood flow more easily. This helps to prevent strokes, heart attacks and kidney diseases.
2. Atropine
Atropine is an anticholinergic drug, which can block adrenergic nerves innervated by cholinergic nerves behind ganglia, reduce the excitability of adrenergic receptors, and achieve the effect of relieving muscle spasm. Atropine is mainly used to treat the pain caused by gastrointestinal spasm, and can also be used to treat renal colic, biliary colic and other diseases.
3. Lidocaine
Lidocaine is a local anesthetic, which can block the conduction of local nerves to relieve pain and discomfort. It is mainly used to treat heart block, ventricular premature beats and other diseases. Lidocaine can also inhibit the central nervous system.

As a new scientific research company, our company can not only provide the conventional α2 receptor agonist Dexmedetomidine hydrochloride, but also provide corresponding antagonists, such as yohimbine (corresponding agonist is clonidine hydrochloride), prazosin hydrochloride (corresponding α1 receptor agonist is (R)-Phenylephrine Hydrochlorid) and so on. At the same time, I can also provide products related to beta-adrenoceptors. If you are interested in related research, please contact us by email in sales6@faithfulbio.com.

Does dexmedetomidine hydrochloride have adverse effects on the brain?

Dexmedetomidine HCL produces sedative, analgesic and anti-anxiety effects by selectively exciting α2- adrenergic receptors, which will make us wonder whether it will irreversibly destroy the central nervous system like some psychotropic products.
Therefore, we contacted Dr. Wang from a psychiatric department, and he told us that there is a significant difference between dexmedetomidine hydrochloride and psychotropic products. This product is mainly used for anesthesia assistance in surgery, and it does not directly act on the central nervous system, but plays a role by affecting the release and transmission of neurotransmitters. Basically, there will be no problems of abuse and dependence. Many other mental products make the nervous system reach a morbid balance by causing or aggravating the dysfunction of the central nervous system, thus completing the relief of the pain. If properly adjusted, it can restore a healthy balance. However, it should be noted that this process is very long and difficult to operate, and there is great potential dependence and tolerance.
We should pay attention to the fact that this product may cause drowsiness, dizziness, nausea and vomiting, itching, bradycardia and hypotension, and due to individual differences, a few patients may also have symptoms such as headache, fever, chills and dyspnea. These symptoms are usually related to the action of drugs on α2 adrenergic receptors. However, we need to pay special attention to the problem of sleepiness. We need to monitor the patient's conscious state and vital signs frequently during use to avoid the risk caused by excessive sedation, and we should always be prepared for emergencies.

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Our strengths:

Our company has passed FDA and ISO19001 quality management system certification. And we have internal cooperation agreements with multiple factories and laboratories in China, so we can not only provide customers with the required DEMEDETOMIDINE HCL products,It can also provide the production and research of other raw powder of adrenoceptor agonists and other related antagonistic raw materials.

We not only have unique advantages in transportation, but also support multiple payment methods, whether you use US dollars, euros, Australian dollars, or local currencies from Singapore, Malaysia, Thailand, and so on. We can also support local currencies in these regions and countries. In addition, we also support bank cards (credit cards, etc.) for payments.

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