Calcium N5-methyltetrahydrofolate CAS 26560-38-3

What is 5-Methyltetrahydrofolate calcium?

Calcium N5-methyltetrahydrofolate is a chemical substance in the folic acid family, specifically the calcium salt crystalline form of levomefolic acid, the active form of folic acid naturally found in the human body.

Physically, it is a stable salt compound formed by the combination of an active folic acid molecule and a calcium ion. Chemically, it is insoluble in dimethyl sulfoxide but soluble in water.

In commercial applications, this product is primarily used as a functional ingredient, commonly found in two areas: firstly, as a core component of high-end dietary supplements, formulated into tablets and capsules for specific populations; and secondly, as a biochemical reagent in life science research, used in basic research scenarios such as cell experiments and animal models. Commercially available products typically have clearly defined purity specifications and require storage at -20°C in the dark to ensure their chemical stability.

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What is the difference between 5-Methyltetrahydrofolate calcium and regular folic acid?

5-Methyltetrahydrofolate calcium is a stable, naturally occurring, active form of calcium salt in the human body. It exists directly in the body and can be absorbed and utilized without any metabolic conversion. Regular folic acid, on the other hand, is a synthetic, inactive precursor that requires multiple conversion steps by the liver and metabolic enzymes to reach its active form. Therefore, the effectiveness of regular folic acid is greatly affected by individual genetic differences-approximately 30%-60% of people with MTHFR gene mutations have low conversion efficiency, and taking regular folic acid may not effectively increase the level of active folic acid in the body. Calcium N5-methyltetrahydrofolate bypasses all metabolic bottlenecks, providing a stable, predictable, and universally applicable supplementation effect without masking vitamin B12 deficiency, making it a better choice for pregnant women, those with hyperhomocysteinemia, and those with MTHFR mutations.

What is the mechanism of action of 5-Methyltetrahydrofolate calcium?

The core mechanism of CalciuM N5-Methyltetrahydrofolate is to act as the natural active form of folic acid in the human body, directly functioning as a "methyl donor" - it transfers its own methyl groups to homocysteine of the same type, converting it into DL-Methionine, thereby reducing the levels of harmful homocysteine to the cardiovascular and nervous systems. This process also generates Ademetionine, providing raw materials for almost all methylating reactions in the body. Unlike traditional Folic acid, Calcium N5-methyltetrahydrofolate can be directly absorbed by the intestines, making it particularly suitable for pregnant women and people with weak metabolic abilities. Moreover, recent studies have found that it also has anti-inflammatory and neuroprotective effects, capable of inhibiting oxidative stress and inflammatory responses, and alleviating nerve damage.

MF of Calcium N5-methyltetrahydrofolate

Stability	Hygroscopicity
Molecular formula	C20H27CaN7O6
Molecular weight	501.56
Form	Solid

Specification

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FAQ:

Q1: Is 5-Methyltetrahydrofolate calciuM (raceMate) the same as Folic acid?
They are different. Nsc173328 is the active form, which can theoretically be directly absorbed, while ordinary Folic acid is the synthetic form and needs to undergo complex transformations in the body before it can be utilized.
Q2: What are the effects of excessive use of Nsc173328?
Because its toxicity is very low, the direct effects of overdosing on Calcium N5-methyltetrahydrofolate are minimal. However, mild discomfort may occur, such as nausea, sleep disturbances, or a bitter taste in the mouth.
Q3:Who should not take 5-Methyltetrahydrofolate calcium?

Those allergic to any of the ingredients in this product should avoid use; patients with epilepsy who are currently taking anticonvulsant products should use with caution; in addition, individuals with psychiatric symptoms should consult a doctor before use.

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