99% Levomefolic Acid CAS 31690-09-2

What is Levomefolic Acid?

Levomefolic Acid is not only the only free form of folate existing in animal blood and cells, but also the most biologically active ultimate form of Folic acid in the human body. In the Folic acid metabolic pathway, it is converted from Folitixorin (a mixture of diastereomers) under the action of specific enzymes, and is the only way for Folic acid to participate in human physiological metabolism. This active molecule then enters the methyl transfer pathway, where it transfers a methyl group to homocysteine to reconvert it into DL-methionine, and subsequently generates Ademetionine - this is the core substance in the body that provides methyl groups for DNA and proteins. This process not only indirectly regulates important epigenetic modifications, but also maintains a lower level of homocysteine in the blood, thereby reducing cardiovascular risks. Based on these core functions, 99% Levomefolic Acid is used for treating megaloblastic anemia, preventing neural tube defects in fetuses, arteriosclerosis, enhancing the therapeutic effect of fluoropyrimidine, and treating some autoimmune diseases, such as psoriasis and rheumatoid arthritis, etc.

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How does levomefolic acid work?

The core mechanism of 99% Levomefolic Acid is to act as the most important methyl donor in the human body, directly participating in the remethylation process of homocysteine. Specifically, with the assistance of Vitamin B12, it transfers its methyl group to homocysteine through the DL-Methionine synthetase enzyme, converting it into DL-Methionine and subsequently generating Ademetionine. This mechanism has two key physiological effects: first, it reduces the level of harmful homocysteine in the blood, thereby providing cardiovascular protection; second, it provides necessary methyl resources for DNA methylation, protein methylation, and the synthesis of neurotransmitters such as serotonin and dopamine.

Why do some people need to take Levomefolic Acid instead of ordinary folic acid?

The fundamental reason lies in the fact that individuals have different genes, and the degree of their body's conversion of Folic acid varies. Ordinary Folic acid, which is not inherently active and is artificially synthesized, requires enzymatic conversion by the methylenetetrahydrofolate reductase enzyme in the human body to become truly active Folic acid. However, approximately 30%-40% of people have this genetic mutation, which significantly reduces the activity of the conversion enzyme, with the lowest activity remaining at only 30%, and most remaining at around 60%. For this group of people, the ordinary Folic acid they consume cannot be effectively converted, even with a large dose, and the amount that can be utilized by the body is very little. This may affect fetal neural tube development and lead to increased cardiovascular risks and other issues.
While 99% Levomefolic Acid does not require enzymatic conversion in the body and is already a mature and effective form of Folic acid, it can be directly absorbed and utilized by the body without being affected by genetic types. For those with abnormal genetic typing, a history of adverse pregnancy, elevated homocysteine levels, or poor response to ordinary Folic acid supplementation, choosing this active Folic acid will better meet their individual needs. The specific supplementation method should still be determined based on the genetic test report or professional medical advice to be more reliable.

MF of Levomefolic Acid

Molecular weight	459.46
Melting point	215-218oC
Density	1.62
Solubility	Alkaline solution,DMSO
Acidity coefficient	3.51±0.10

Specification

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FAQ:

Q1: Is levomefolic acid safe? Does it have any side effects?
Normal and reasonable supplementation with (6S)-5-Methyltetrahydrofolic acid generally does not produce adverse reactions. However, a very small number of people may experience mild gastrointestinal bloating, nausea, or mild skin itching and rashes, which are temporary discomforts. As long as the recommended dosage is followed and overdose is avoided, the overall risk of use is low.
Q2: What is the difference between Levomefolic Acid and Calcium N5-methyltetrahydrofola?
Both have the same active ingredient, differing only in their chemical form. The latter is a calcium salt structure, stable and easily soluble, and is often used in dietary products; 99% Levomefolic Acid is in its free acid form and is commonly used in scientific research. After ingestion, they have the same effect, both directly participating in Folic acid metabolism.
Q3:Who should not take Levomefolic Acid?

Individuals allergic to any of the active Folic acid components should not take this medication.

Patients with malignant tumors should not supplement without medical advice.

Persons taking epilepsy medication should follow their doctor's instructions and should not increase their dosage on their own.

Persons with severe liver or kidney metabolic abnormalities should be evaluated before use.

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