5'-Deoxy-2',3'-di-O-acetyl-5-fluorocytidine is a white to almost white powder crystal that is a pharmaceutical intermediate for the synthesis of capecitabine. This is an anti metabolic fluoropyrimidine deoxyribonucleoside carbamate drug that can be converted into 5-FU in the body. The finished product Capecitabine Impurity M powder, can inhibit cell division and interfere with RNA and protein synthesis.
| structural formula |
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Item |
Standard |
Test Results |
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Appearance |
White or off-white powder |
white powder |
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Identification |
The retention time of the major peak of the assay preparation corresponds to that of the standard preparation, as obtained in the assay. |
99.50% |
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Solubility |
Soluble in methyl alcohol |
Conforms |
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Loss on Drying |
≤1.00% |
0.21% |
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Heavy Metals |
≤ 10ppm |
(Pb)0.08 ppm |
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Sulfated Ash |
≤ 0.10% |
0.03% |
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Total plate count |
≤1000 CFU/g |
2.8 CFU/g |
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Yeast&Mold |
≤50 CFU/g |
0.8 CFU/g |
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Related Substances |
Impurity A: ≤0.30% |
0.18% |
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Other unknown impurity: ≤0.10% |
0.07% |
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Total Impurities: ≤0.50% |
0.42% |
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Residual Solvent |
Methylbenzene≤0.089% |
Conforms |
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Ethyl acetate≤0.5% |
Conforms |
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n-Heptane≤0.5% |
Conforms |
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Assay |
98.0%~102.0% |
98.8% |
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Conclusion： |
Conform with enterprise specification . |
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What is the new method for the synthesis of Capecitabine Impurity C (EP )?
5'-Deoxy-2',3'-di-O-acetyl-5-fluorocytidine was synthesized from 5-fluorocytidine by selective bromination at 5' hydroxyl group under the action of PPh,/／Br2, and then the bromine atom was reduced by PD/C in two steps with an overall yield of 52%. This method has the advantages of easily available raw materials, simple route, high yield and single product configuration, which provides a new way for the synthesis of capecitabine and its compounds and has potential application prospects.
What should be noted when using Capecitabine Impurity?
Capecitabine Impurity manufactured goods is a kind of bone marrow inhibitor, so before each experiment, blood tests are needed to monitor blood cells and platelet counts. No side effects caused by drug overdose were found. However, in animal experiments and the treatment of people with the maximum tolerated dose, the manifestations of drug overdose are nausea, vomiting, diarrhea, gastrointestinal irritation, gastrointestinal bleeding and bone marrow suppression. Sometimes the reaction is extremely strong, and it needs to be dehydrated by using diuretics and treated by dialysis if necessary.
A variety of shipping methods for you to choose
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Transportation Time |
Shipping method |
Cargo weight requirements |
Advantage |
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3-7 days |
DHL,Germany DHL,Germany DPD, |
Suitable for under 50kg. |
We have warehouses in Germany and California, USA, |
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7-15 days |
By Air |
Suitable for more than 50kg. |
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15-60 days |
By Sea |
Suitable for more than 500kg. |
Our strengths:
Our company has passed FDA and ISO19001 quality management system certification. And we have internal cooperation agreements with multiple factories and laboratories in China,Our company can provide Capecitabine Impurity powder etc. at a more favorable price. If you are interested, please leave a message.
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