what is 1h Tetrazole?
1h Tetrazole are a class of synthetic organic heterocyclic compound, consisting of a 5-member ring of four nitrogen atoms and one carbon atom. The name tetrazole also refers to the parent compound with formula CH2N4, of which three isomers can be formulated.
 |
Product name |
1h Tetrazole |
|
CAS |
288-94-8 |
|
|
Molecular formula |
CH2N4 | |
|
Molecular weight |
70.05 | |
|
EINECS Number |
206-023-4 | |
|
Storage condition |
Room temperature. | |
|
Appearance |
White powder | |
|
Melting point |
156-158°C | |
| Solubility | Soluble in dimethyl sulfoxide and methanol |
What is Structure and Bonding of 1h Tetrazole?
Three isomers of the parent tetrazole exist, differing in the position of the double bonds: 1H-, 2H-, and 5H-tetrazole. The 1H- and 2H- isomers are tautomers, with the equilibrium lying on the side of 1H-tetrazole in the solid phase. In the gas phase, 2H-tetrazole dominates.These isomers can be regarded as aromatic, with 6 π-electrons, while the 5H-isomer is nonaromatic.
Phosphorus analogs do not have the same electronic nature, with 1H-tetraphosphole having a more pyramidal geometry of the phosphorus at position1. Instead, it is the anionic tetraphospholides that are aromatic.
Strongly inductively electron-withdrawing functional groups attached to a tetrazole may stabilize a tautomeric ring-opening equilibrium with an azidoimine form.If you need it, pls click e-mail sales1@faithfulbio.com
what are the uses of 1h Tetrazole?
1h Tetrazole can be used as an important pharmaceutical and fine chemical intermediate, so the study of its synthesis has significant practical significance.
Used as an intermediate for the drug cilostazol
Peptide coupling agent; Used as a catalyst in the synthesis of oligonucleotides when using triester phosphine method
Product Specification
|
Items |
Requirement |
Analysis Result |
|
Appearance |
Colorless transparent liquid |
Colorless transparent liquid |
|
Identification |
HPLC(+) |
HPLC(+) |
|
1H-Tetrazolel Purity |
≥99.0% |
99.7% |
|
Assay |
(20±0.5)% |
20.0% |
|
Water Assay |
(80±0.5)% |
80.0% |
how to Synthesis 1h Tetrazole?
1h-Tetrazole was first prepared by the reaction of anhydrous hydrazoic acid under pressure. A Pinner reaction of organic nitriles in the presence of a buffered strong acid (e.g. triethylammonium chloride) synthesizes 5-substituted 1H-tetrazoles cleanly.
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Shipping method |
Cargo weight requirements |
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3-7 days |
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