Neratinib powder is a gray-white solid targeted product and a targeted drug for the treatment of chronic myeloid leukemia. Pure HKI 272 is a second generation tyrosine kinase inhibitor, which can inhibit the growth and survival of tumor cells, thus achieving the purpose of treatment. It is mainly used to treat chronic myeloid leukemia, and can also be used to treat diseases such as myelofibrosis and polycythemia vera.
| structural formula |
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| ITEMS | SPECIFICATIONS | RESULTS | |||
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Appearance |
White or slightly yellowish powder |
Conform |
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Identification |
Consistent with the standard sample |
Conform |
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Assay(on dried basis) |
≥ 98.8% |
99.85% |
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Loss on Drying |
≤5% |
2.88% |
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|
Lead |
≤1ppm |
<1ppm |
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Heavy Metal |
≤20ppm |
<20ppm |
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Chloride |
≤0.5% |
<0.5% |
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Sulfate |
≤0.24% |
<0.24% |
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Clarity and Color of Solution |
≤0.35 |
0.158 |
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Molds & Yeast |
≤100cfu/g |
<10cfu/g |
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E.Coli |
Negative |
Negative |
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Salmonella |
Negative |
Negative |
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| Conclusion： | Conforms to USP32 . | ||||
What are the differences between Neratinib and Pyrotinib?
First of all, Neratinib is a new generation of targeted therapy drugs, mainly used for the treatment of HER2 positive breast cancer. HER2 (human epidermal growth factor receptor 2) is a protein that is overexpressed on certain cancer cells. Neratinib blocks the growth and spread of cancer cells by inhibiting the activity of HER2 and other key signaling pathways. Pyrotinib is a CDK4/6 inhibitor. CDK4/6 is an important protein kinase complex in the cell cycle that regulates cell growth and proliferation. SHR1258 inhibits the activity of this complex, preventing cancer cells from entering the S phase of the cell cycle and thus suppressing their growth.
Secondly, there are some differences between the usage of Neratinib and SHR1258. Neratinib is usually used once a day for one year. It can be used as an adjuvant therapy for early HER2 positive breast cancer after surgery, and can also be used for metastatic breast cancer. Pyrotinib was used once a day for 21 days, and then stopped for 7 days, which constituted a treatment cycle. It is usually used in combination with other drugs, such as hormone therapy.
Finally, the side effect is also an important difference between Neratinib powder and SHR1258. The common side effects of lenatinib include nausea, vomiting, diarrhea, fatigue and dry skin. Serious side effects include liver damage and heart problems. The common side effects of SHR1258 include low white blood cell count, low red blood cell count, fatigue and vomiting. In contrast, the side effects of Pyrotinib are more common and serious.
To sum up, Neratinib and Pyrotinib are two drugs used to treat breast cancer. There are some differences in their mechanism of action, usage and side effects. Choosing the right medicine should be based on the patient's specific situation and the doctor's advice. Despite some side effects and risks, the targeted therapy of these drugs in the treatment of breast cancer is still an important progress, which can help patients prolong their survival and improve their quality of life.
A variety of shipping methods for you to choose
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Transportation Time |
Shipping method |
Cargo weight requirements |
Advantage |
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3-7 days |
DHL,Germany DHL,Germany DPD, |
Suitable for under 50kg. |
We have warehouses in Germany and California, USA, |
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7-15 days |
By Air |
Suitable for more than 50kg. |
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15-60 days |
By Sea |
Suitable for more than 500kg. |
Our strengths:
Our company has passed FDA and ISO19001 quality management system certification. And we have internal cooperation agreements with multiple factories and laboratories in China,Our company can provide Neratinib powder etc. at a more favorable price. If you are interested, please leave a message.
We not only have unique advantages in transportation, but also support multiple payment methods, whether you use US dollars, euros, Australian dollars, or local currencies from Singapore, Malaysia, Thailand, and so on. We can also support local currencies in these regions and countries. In addition, we also support bank cards (credit cards, etc.) for payments.
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