What is Vancomycin Hydrochloride ?
Vancomycin Hydrochloride is a glycopeptide antibiotic, which is the hydrochloride of vancomycin. It is white or white-like crystalline powder at room temperature. Its mechanism of action is that it binds to alanyl alanine at the poly-terminal of the precursor peptide of sensitive bacterial cell wall with high affinity, blocking the synthesis of macromolecular peptidoglycan that constitutes bacterial cell wall, leading to cell wall defect and killing bacteria. In addition, Vancomycin Hydrochloride powder may also change the permeability of bacterial cell membrane and selectively inhibit RNA synthesis.
| Product name | Vancomycin Hydrochloride powder |
| CAS | 1404-93-9 |
| Molecular formula | C66H76Cl3N9O24 |
| Molecular weight | 1485.72 |
| EINECS Number | 604-193-8 |
| melting point | >190°C (dec.) |
| specific rotation | [α]D20 -30～-40゜ (c=1, H2O) |
| flash(ing) point | 87℃ |
| Storage condition | Room temperature preservation |
What is the function of Vancomycin Hydrochloride powder ?
clinical application
1. It is used for serious Gram-positive bacterial infections, especially serious infections (such as endocarditis, meningitis, osteomyelitis, pneumonia, septicemia or soft tissue infection, etc.) caused by methicillin-resistant Staphylococcus aureus, Staphylococcus epidermidis and enterococcus that are resistant to other antimicrobial agents or have poor curative effect; It is also used for the above-mentioned serious infection of people who are allergic to β -lactam antibiotics.
2. Vancomycin Hydrochloride powder can be used to treat arteriovenous shunt infection caused by Staphylococcus in hemodialysis patients.
3. It is also suitable for the treatment of pseudomembranous colitis who is ineffective after metronidazole treatment, or multi-drug resistant staphylococcal enterocolitis.
pharmacodynamics
The characteristic of this product is that it has strong bactericidal effect on gram-positive bacteria; Has good curative effect on treating Clostridium difficile pseudomembranous colitis. The antibacterial spectrum has strong antibacterial activity against Staphylococcus aureus, Staphylococcus epidermidis, Streptococcus pyogenes and Streptococcus pneumoniae.Vancomycin Hydrochloride powder also has certain antibacterial effects on anaerobic streptococcus, Clostridium difficile, anthrax, actinomycetes, diphtheria, Neisseria gonorrhoeae, Streptococcus viridis, Streptococcus bovis and Streptococcus faecalis. It has no effect on most gram-negative bacteria, Mycobacterium, Rickettsia, Chlamydia or fungi.
Product Specification
| Item | Specifications | Result |
|
Appearance |
white or almost white powder | Conform |
|
Assay |
98.0%-101% |
99.15% |
| Identification | Infrared Absorption | Conform |
| PH | 2.5-4.5(50mg/ml) | 2.9 |
| Chromatographc purity | Vancomycin B: 88.0%min Any peak other than the main pea: 4.0% max |
4.3% 1.3% |
| Monodechlorovancomycin | 4.7% max | 1.4% |
| Water,K.F | 5.0% max | 3.1% |
| Bacterial endotoxins | 0.25EU/mg max | Conform |
| Potency(dried substances) | 925μg/mg min | 1109ug/mg |
| Particulate matter | The particle of more than 10um no more than 6000/1g The particle of more than 25um no more than 600/1g |
317/g 5/g |
| Heavy metals | 30ppm max | Conform |
| Sterility | Conform | Conform |
| Clarity | Conform | Conform |
| Residual solvents | Ethanol: 5000ppm max | 15ppm |
| Conclusion: The test results are conformed to the in-house specification | ||
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Shipping method |
Cargo weight requirements |
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Attention: It should be noted that this product is not intended for the diagnosis, treatment, cure, or prevention of any disease. Please consult your doctor and learn about available research before use. Please do not use without authorization. This compound can only be used for research purposes. The US Food and Drug Administration has not evaluated these claims.
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