what is phenazone?
Phenazone is an analgesic (pain reducing), antipyretic (fever reducing) and anti-inflammatory drug. While it predates the term, it is often classified as a nonsteroidal anti-inflammatory drug (NSAID). Phenazone was one of the earliest synthetic medications - when it was patented in 1883, the only synthetic medical chemicals on the market were chloral hydrate, a sedative (as well as at least one derivative of that chemical), trimethylamine, and iodol (tetraiodopyrrol), an early antiseptic. One of the earliest widely used analgesics and antipyretics, phenazone was gradually replaced in common use by other medications including phenacetin (itself later withdrawn because of safety concerns), aspirin, paracetamol and modern NSAIDs such as ibuprofen. However, it is still available in several countries either as an over-the-counter or prescribed drug.
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Product name |
phenazone |
|
CAS |
60-80-0 |
|
|
Molecular formula |
C11H12N2O | |
|
Molecular weight |
188.23 | |
| EINECS | 200-486-6 | |
|
Appearance |
White powder | |
|
Melting point |
109-111 °C(lit.) | |
| Storage | 2-8°C | |
| Solubility | Solubility in water is less than 1g/ml |
What is phenazone used for?
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|
1 Phenazone is used as an antipyretic and analgesic drug If you need it, pls click e-mail sales1@faithfulbio.com |
What are Adverse effects of phenazone?
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Possible adverse effects of phenazone include:
Allergy to pyrazolones
Nausea
Agranulocytosis
Hepatotoxicity |
Product Specification
|
Items |
Specifications |
Results |
|
Appearance |
white powder |
Conform |
| Identification | IR | Conform |
|
Loss on drying |
1%max. |
0.4% |
|
Assay |
98.0%min. |
99.4% |
|
Heavy metals |
20ppm max |
Conform |
Conclusion：Conform with specification and qualified.
what is the Preparation of phenazone?
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Phenazone is synthesized by condensation of phenylhydrazine and ethyl acetoacetate under basic conditions and methylation of the resulting intermediate compound 1-phenyl-3-methylpyrazolone with dimethyl sulfate or methyl iodide. It crystallizes in needles which melt at 156 °C (313 °F). Potassium permanganate oxidizes it to pyridazine tetracarboxylic acid |
How and where to buy phenazone wholesale?
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A variety of shipping methods for you to choose
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Transportation Time |
Shipping method |
Cargo weight requirements |
Advantage |
|
3-7 days |
DHL, Germany DHL, Germany DPD, |
Suitable for under 50kg. |
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By Air |
Suitable for more than 50kg. |
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By Sea |
Suitable for more than 500kg. |
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