What is cefazolin sodium salt ?
Cefazolin Sodium is white or white-like powder or crystalline powder; Odorless; Taste slightly bitter; Easy to get wet. It is easily soluble in water. This kind of medicine can destroy the cell wall of bacteria and sterilize them during the breeding period. It has a strong selective effect on bacteria, but has almost no toxicity to people. It has the advantages of broad antibacterial spectrum, strong antibacterial effect, penicillin enzyme resistance and less allergic reaction than penicillins. Therefore,cefazolin sodium salt is an important antibiotic with high efficiency, low toxicity and wide clinical application. It is a semi-synthetic first-generation cephalosporin, which has antibacterial effect on both gram-positive and gram-negative bacteria, and is superior to the second and third-generation cephalosporins.
| Product name |
cefazolin sodium salt |
| CAS | 27164-46-1 |
| Molecular formula | C14H15N8NaO4S3 |
| Molecular weight | 478.5 |
| EINECS Number | 248-278-4 |
| melting point | 190 °C |
| refractive index | 20 ° (C=10, H2O) |
| solubility | H2O：50 mg/mL |
| stability | Stable, but may be sensitive to heat, stored in a cool condition. |
| Storage condition | Keep in dark place,Inert atmosphere,2-8°C |
What are the indications for cefazolin sodium salt ?
The antibacterial spectrum is similar to cefalexin, and it has antibacterial effects on Staphylococcus (including enzyme-producing strains), Streptococcus (except enterococcus), Streptococcus pneumoniae, Escherichia coli, Proteus mirabilis, Klebsiella pneumoniae, Haemophilus influenzae and Enterobacter aerogenes. cefazolin sodium salt is characterized by strong action on gram-positive bacteria and weak resistance to β -lactamase of staphylococcus. Clinically, it can be used for infections of respiratory tract, urogenital system, skin and soft tissue, bones and joints, biliary tract, etc. caused by sensitive bacteria, and can also be used for endocarditis, septicemia, pharyngeal and ear infections.
Cefazolin Sodium Salt can also be used as a preventive medicine before surgery. It is not suitable for central nervous system infection. The curative effect on chronic urinary tract infection, especially those with abnormal urinary tract anatomy, is poor. It is not suitable for treating gonorrhea and syphilis. cefazolin sodium salt is suitable for treating respiratory tract infections such as otitis media, bronchitis and pneumonia, urinary tract infections, skin and soft tissue infections, bone and joint infections, septicemia, infective endocarditis, hepatobiliary system infections and eye, ear, nose and throat infections caused by sensitive bacteria.
Product Specification
| Item | Specifications | Result |
|
Appearance |
White crystalline powder | Complies |
| Assay (HPLC basis on drying) |
89.1%~110.1% | 96.70% |
| Optical Rotation | -10°~-24° | -21° |
| Particle Size | 98% pass 80mesh | Complies |
| Water | ≤ 6.00% | 0.80% |
| pH | 4.0~6.0 | 5.1 |
| Bacterial Endotoxins | ≤0.15 USP EU/mg of cefazolin | Complies |
| Sterility | Should be sterile | Complies |
| Heavy Metal | ||
| Lead (Pb) | ≤2.0ppm | Complies |
| (As) | ≤1.0ppm | Complies |
| (Cd) | ≤1.0ppm | Complies |
| (Hg) | ≤0.1ppm | Complies |
| Microorganism | ||
| Total Plate Count | ≤1000cfu/g | Complies |
| Yeasts and Molds | ≤100cfu/g | Complies |
| Saimonella | Negative/25g | Complies |
| E.coli | Negative | Complies |
| Conclusion: The test results are conformed to the in-house specification | ||
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Attention: It should be noted that this product is not intended for the diagnosis, treatment, cure, or prevention of any disease. Please consult your doctor and learn about available research before use. Please do not use without authorization. This compound can only be used for research purposes. The US Food and Drug Administration has not evaluated these claims.
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