Oleanolic Acid Powder CAS 508-02-1

Oleanolic Acid powder is mainly extracted from the following plants:

Swertia macrophylla of Swertia of Gentianaceae.
The fruit of Ligustrum lucidum
Leaves of oleander in Oleaceae
Leaves and roots of the Umbelliferae plant Celery.
Root bark and stem bark of Araliaceae Aralia elata.
Tuberous roots of Cucurbitaceae plants, such as Hemerocallis crassipes, Hemerocallis adorata and Hemerocallis sinensis (Scarabaga, Luoguodi).
Among them, the content of Cucurbitaceae plant is relatively high, ranging from 1.5% to 2%, and the content of Ligustrum lucidum fruit is 0.6% to 0.7%.

The main source of Oleanolic Acid powder is Olea europaea, also known as "olive", is a very typical woody oil plant in the Mediterranean region. Belongs to Oleaceae. The ancient Greeks and Jews regarded the fruit of Zidunguo as a symbol of peace. In Spain, Italy and Argentina, Qidun fruit forest occupies a huge area. It is less distributed in other places. Elaeagnus angustifolia is a kind of tree with a height of 3-7 meters. Its leaves are evergreen and drupe is 1-3 cm long. Its mesocarp contains 25-40% oleaginous fruit, which is rich in vitamins and easy to be digested by organisms. In medicine, this oil is used to prevent arteriosclerosis. At present, it mainly grows in cultivated or wild state.

Oleanolic Acid powder mainly has the functions of protecting liver, lowering enzymes, promoting hepatocyte regeneration, anti-inflammatory, strengthening heart, diuresis, etc., and also has the functions of lowering blood sugar, lowering blood fat and calming, and is an effective component for developing drugs for treating liver diseases and lowering blood sugar.

1. Alleviate liver injury: It is a pentacyclic triterpenoid compound, which has obvious protective effect on acute and chronic liver injury caused by carbon tetrachloride in rats. After treatment, swollen mitochondria and expanded rough endoplasmic reticulum were restored. It can also significantly reduce balloon degeneration, necrosis and inflammatory reaction of liver cells in acute and chronic liver injury. The accumulation of triglyceride in liver decreased and the amount of glycogen increased.

2. Decrease the activity of plasma alanine aminotransferase: It has obvious enzyme reducing effect on acute, chronic hepatitis and liver cirrhosis animals.

3. Decrease serum r- globulin: which is consistent with the reduction of liver-related inflammatory reaction observed by histological observation.

4. Promote the regeneration of hepatocytes: It can significantly increase the number of mitotic phases in the residual liver of rats, and the degree of regeneration is higher than that of the control group, suggesting that it can promote cell regeneration.

5. Reduce the level of kynurenine in brain homogenate of rats with liver cirrhosis: Because the level of kynurenine in brain homogenate is obviously decreased, it can inhibit the production of false neurotransmitters, so Oleanolic Acid powder is beneficial to the prevention and treatment of hepatic encephalopathy.

6. Inhibition of hepatic fibrosis: In rats with hepatic fibrosis treated with Oleanolic Acid, hepatic fibrosis is severe and obviously reduced, and the content of hepatic collagen is reduced, suggesting that it has the function of preventing and treating liver cirrhosis.

It has obvious inhibitory effect on mononuclear phagocyte system, macrophage phagocytic function and experimental arthritis in mice, but it has influence on humoral immune function and antigen-binding cells. Enhance immunity and inhibit the growth of S180 tumor strain.

Oleanolic Acid powder can protect chromosome damage, prevent experimental atherosclerosis and correct protein metabolism disorder.