Dihydroberberine Powder CAS 483-15-8

Dihydroberberine Introduction

Xi'an Faithful BioTech Co., Ltd. is an export-oriented biotechnology and chemical trading company headquartered in Xi'an, Shaanxi Province, China. Founded in 2018, the company focuses on providing pharmaceutical intermediates, plant extracts, food additives, and feed ingredients to the global B2B market.  

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Dihydroberberine Powder is mainly derived from plants. Currently, it is mainly applied in anti-inflammatory, intestinal health and immune regulation, research on metabolic diseases, and intervention in tumor studies. CAS Number: 483-15-8; Molecular formula: C20H19NO4 Molecular weight: 337.37;

What are the uses of dihydroberberine?

Dihydroberberine is a naturally occurring isoquinoline alkaloid with multiple biological activities. Its related physiological effects cover various health research directions and possess considerable scientific exploration value. In terms of metabolic regulation, this substance can target and regulate glucose kinase, enhance the insulin secretion capacity induced by glucose, assist in maintaining the body's sugar indicators in a stable state. Moreover, relevant studies have confirmed that it also has the functions of regulating lipids and improving the manifestations related to atherosclerosis. In the aspect of inflammatory-related regulation, Dihydroberberine Powder can simultaneously regulate multiple core signaling pathways such as NF-κB and MAPK to weaken inflammatory responses. It can alleviate the discomfort manifestations in intestinal inflammatory-related models. The action pathways include regulating the TLR4/MyD88/NF-κB pathway, down-regulating the expression of pro-inflammatory factors, and stabilizing the intestinal barrier structure. Additionally, this substance can efficiently inhibit the synthesis enzyme of hematopoietic type prostaglandin D2 and reduce the generation of pro-inflammatory mediator PGD2, providing new ideas for research on allergic, inflammatory-related abnormal states, and even Duchenne muscular dystrophy. In the aspect of immune balance regulation, Dihydroberberine can act on the Rheb/mTOR signaling pathway, promoting the transformation of CD4+T cells into regulatory T cells (Treg), and alleviating the imbalance of Th17/Treg cell ratio in autoimmune-related models such as premature ovarian insufficiency. Moreover, existing basic research has also observed that Dihydroberberine has the ability to inhibit abnormal proliferating cells. At the same time, it can prevent osteoclast differentiation, providing a reference for research in the direction of bone tissue damage.

What is the mechanism of action of dihydroberberine?

The working mechanism of Dihydroberberine Powder is much like a "universal key", which can simultaneously unlock multiple different "locks" within cells. The most crucial "lock" is called AMPK. When Dihydroberberine activates AMPK, the cells mistakenly believe that there is insufficient energy, and thus actively accelerate the "burning" of glucose and fat to replenish energy. This is the reason why it can affect blood sugar and metabolism. At the same time, it also regulates another "growth signaling pathway" called mTOR, which is closely related to the balance of immune cells. By adjusting it, it can help correct inflammatory problems caused by excessive immune system responses. Moreover, Dihydroberberine can directly inhibit certain enzymes related to inflammation (such as H-PGDS), thereby reducing the production of pro-inflammatory substances. Therefore, the reason why it seems to affect multiple aspects is that it acts on several very basic and universal regulatory hubs within the cells, rather than targeting a specific symptom.

MF of Dihydroberberine

CAS	483-15-8
Molecular formula	C20H19NO4
Molecular weight	337.37
Density	1.37±0.1 g/cm3
Melting point	223-224℃
Boiling point	557.8±50.0 °C

Specification

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FAQ: 

Q1:What is the fundamental difference between dihydroberberine and the regular berberine?
Each molecule contains multiple hydrogen atoms, making it more lipid-soluble. The absorption rate in the human body is much higher than that of the latter.
Q2:Is dihydroberberine classified as a stimulating raw material?
Powder should not be inhaled directly. In case of contact with skin or eyes, rinse with water immediately. It is recommended to wear gloves and a mask during operation.
Q3:What is the specific source of dihydroberberine?

It is mainly extracted from plants belonging to the Berberis genus, such as COPTIDISRHIZOMA, Phellodendri Chinensis Cortex, and Three needles, and can also be prepared through chemical synthesis.

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