Chlorogenic Acid Powder CAS 327-97-9

It mainly exists in plants of the Lonicera family, Lonicera genus, and Asteraceae, with higher levels found in Eucommia ulmoides leaves (2-5%), honeysuckle (1-5.9%), sunflower seeds (1.5-3%), and coffee beans (2-8%). Needle shaped crystals obtained from water are semi hydrated K complexes, which become anhydrous at 110 ℃. Melting point 208 ℃, [α] D25-33.5 ° (water, C=1), K=2.2 × 10-3 (27 ℃). Has a weak acidic odor and has astringency. At 25 ℃, the solubility in water is 4%, making it relatively soluble in hot water

Chlorogenic Acid Powder is the main component of raw coffee, and its extract can promote weight loss in overweight and obese individuals. Chlorogenic acid is an important intermediate in lignin biosynthesis. Chlorogenic acid is an antioxidant and inhibitor of phorbol ester's pro tumor activity. It has a protective effect on diabetes caused by oxidative stress produced by streptozotocin nicotinamide, and can also prevent cardiovascular diseases.
The chlorogenic acid contained in honeysuckle has a choleretic effect and can enhance bile secretion in rats
It can lower blood sugar levels and increase the concentration of liver glucose-6-phosphate and glycogen.
It has a wide range of antibacterial effects, including choleretic, hemostatic, leukocyte increasing, and antiviral effects, as well as the ability to shorten blood clotting and bleeding time. Used to treat upper respiratory tract infections, reduce inflammation and fever, cool blood and dissipate heat

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Result

Appearance

brown powder to brown yellow

Partical size 

100% through 80mesh

Conforms

Assay(hplc)

≥50%

52.8%

Loss on drying

≤5%

3.8%

Moisture content

≤5%

3.6%

Heavy metals

≤10ppm

Conforms

Arsenic

≤2.0ppm

Conforms

Cadmium

≤2.0ppm

Conforms

Lead

≤5.0ppm

Conforms

Mercury

≤1.0ppm

Conforms

Chlorogenic Acid Powder has a better inhibitory effect on both Gram-positive and negative bacteria. The main mechanisms can be summarized as follows: (1) Destroy the structure of cell membranes, causing leakage of intracellular metabolites and trigger cell inactivation; (2) Interfering with normal cell cycle progression, thereby inhibiting the growth of microorganisms; (3) Disturb the normal metabolic activities of bacterial cells, leading to metabolic disorders within the cells

Microbial Strain Selection:

Engineered strains of Escherichia coli or Saccharomyces cerevisiae (yeast) are often used as hosts for CGA production.

Pathway Engineering:

A de novo biosynthetic pathway for CGA is constructed in the chosen microbe by incorporating genes involved in the shikimate pathway and related metabolic pathways.

Optimization:

The metabolic pathways are optimized by increasing the flux of precursor molecules, enhancing cofactor availability, and balancing pathway fluxes.

Fermentation:

The engineered microbes are cultivated in a bioreactor under controlled conditions to produce CGA from a suitable carbon source like glucose