Acacetin CAS 480-44-4
Product Name:Acacetin
Synonym:Linarigenin;Acacetin;Buddleoflavonol;5,7-Dihydroxy-4'-methoxyflavone
CAS NO.:480-44-4
EINECS NO.:207-552-3
Molecular Formula:C16H12O5
Purity & Grade: Different specifications; Medicine grade
Character:Yellow Powder
Free sample:Available
Stock:In stock
Warehouse: USA/EU/AU Warehouse
MOQ & Package: 1g; Package according to demand
Shipping: Safe and fast delivery
Lead Time: 7-15 days
Store & Shelf life: Cool & dry place; 24 months
Description
Product description

Acacia Farnesiana (Linn.)Willd. It is a leguminous plant. Shrub, 2-4 meters tall; The branches have thorns, which can reach a length of 1 to 2 centimeters. Double pinnate compound leaves, with 4 to 8 pairs of pinnate leaflets, each pinnate having 10 to 20 pairs of small leaves, and the small leaves are linear and oblong. The pods are cylindrical, measuring 3 to 7 centimeters in length and 8 to 15 millimeters in diameter. The seeds are mostly black. The flowers are extremely fragrant and are used for extracting essence. Spiny shrubs or small trees, with double pinnate compound leaves, capitula clustered in the leaf axils, when in full bloom, they look like golden pom-poms.
As a natural product molecule, Acacetin has special effects such as relieving depression, regulating qi, calming the mind and promoting blood circulation, and is widely used in biochemical research. In addition, Acacetin also has antioxidant, anti-inflammatory and anti-cancer effects. It plays a role in firming the skin in the sensitive formula firming and anti-wrinkle powder/firming and anti-wrinkle water. Acacetin is selective towards both normal cells and cancer cells, and can inhibit the invasion and migration of cancer cells such as gastric cancer, human non-small cell lung cancer, prostate cancer and T-cell leukemia. The anti-cancer mechanism of Acacetin is related to multiple effects, including inhibiting the activation of nuclear factors by influencing the activation of IκB kinase and the phosphorylation of protein kinase B (Akt).

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COA
| ltems | Standard | Results |
| Assay by HPLC | ≥98.0% | 98.64% |
| Appearance | Light yellow to yellowish crystalline powder | Complies |
| Identification | Should comply with standard | Complies |
| Odor &taste | Characteristic | Characteristic |
| Mesh size | 100%pass 80 mesh | Complies |
| Loss on drying | ≤1.0% | 0.32% |
| Residue on ignition | ≤0.2% | 0.10% |
| Heavy metals | ≤20ppm | <20ppm |
| As | ≤2ppm | <2ppm |
| Microbiology: Total Plate Count Yeast &Mold E.Coli S.Aureus Salmonella |
≤1000cfu/g ≤100cfu/g Negative Negative Negative |
<1000cfu/g <100cfu/g Negative Negative Negative |
| Conclusion | Conform with enterprise specification | |
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Density: 1.4±0.1 g/cm ³
Boiling point: 518.6±50.0 °C at 760 mmHg
Melting point: 260-265 °C(lit.)
Molecular formula: C16H12O5
Molecular weight: 284.263
Flash point: 198.3±23.6 °C
Precise mass: 284.068481
PSA 79.90000
LogP 3.15
What is Acacetin used for?
Acacetin is a potent molecule reported for its strong anti-inflammatory and anti-cancer activity, however further scientific evidence is essential to validate its potency in disease models associated with inflammation and cancer.
What is the mechanism of action of Acacetin?
The mechanism of action of acacetin involves the reduction of phosphorylation of JNK, p38 MAPK, PI3K/Akt, and GSK-3β. The researchers suggested that acacetin should be considered as a therapeutic agent to slow the progression of Parkinson's disease.
What are the sources of Acacetin?
Acacetin is a di-hydroxy and mono-methoxy flavone present in various plants, including black locust, Damiana, Silver birch.
Properties of Acacetin
From a chemical perspective, Acacetin is a flavonoid compound with two phenolic hydroxyl groups and a conjugated carbonyl structure in its structure. It has strong fluorescence properties and good chemical conversion activity. A conjugated system refers to a series of continuous π bonds that can share electrons, making it easier for electrons to flow within a molecule. The conjugated carbonyl structure gives Acacetin a strong fluorescent property in terms of light absorption and emission. This substance can undergo etherification reactions with alkyl halogenated compounds under alkaline conditions to obtain the corresponding ether derivatives. This substance contains a highly electron-rich olefin unit in its structure, which is prone to oxidation by oxidants and deterioration. Generally, it needs to be sealed and stored in a low-temperature environment (2-8 degrees in a refrigerator).
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