Glycine, glycyl-L-α-glutamyl-L-lysyl- Introduction
Tetrapeptide 21, with the CAS number 960608‑17‑7, is an artificially synthesized small molecule peptide. Its amino acid sequence is GEKG. The molecular formula is C15H27N5O7; the molecular weight is 389.4. Its peptide structure is based on some of the signal segments naturally present in human skin and belongs to a signaling type peptide. It is mostly used as a cosmetic raw material in the market. The working logic of Glycine, glycyl-L-α-glutamyl-L-lysyl- is not to directly supplement collagen, but to act on the fibroblasts in the dermis layer, sending signals to the cells and promoting the expression level of genes related to extracellular matrix, thereby stimulating the production of type I collagen, hyaluronic acid, and fibronectin. In terms of skin care effects, it helps to reduce fine lines, improve skin laxity, and enhance the firmness and elasticity of the skin.
What are the differences between Glycine, glycyl-L-α-glutamyl-L-lysyl- and Palmitoyl Pentapeptide?
Both belong to the category of signal peptides, but there are significant structural differences. Palmitoyl Pentapeptide is additionally attached with a palmitic acid chain and undergoes lipid modification, mainly to enhance lipid solubility and facilitate penetration through the skin barrier. In contrast, Tetrapeptide 21 does not have such lipid modification and is a non-lipidated peptide. It has better water solubility and performs better in formula formulation, making it more suitable for a wider range of application scenarios.
In terms of efficacy orientation, there are also differences. The core of Palmitoyl Pentapeptide focuses on stimulating collagen synthesis, mainly targeting the support of the skin framework; Tetrapeptide-21 USP/EP/BP, in addition to promoting collagen production, can also drive the production of hyaluronic acid and fibronectin. In simple terms, the former is more focused on consolidating the internal support structure of the skin, while the latter is a comprehensive player, capable of simultaneously addressing skin support, moisturizing ability, and cell adhesion-related aspects.
What is the mechanism of action for glycine, glycyl-L-α-glutamyl-L-lysyl at low concentrations?
It does not rely on self-packing or covering. Tetrapeptide 21 acts as a triggering signal - as long as a small number of molecules successfully reach the target location and bind to the corresponding receptors on the fibroblast surface, it can initiate a series of chain reactions, causing the cells to actively accelerate the synthesis of collagen and hyaluronic acid. This process is somewhat like pressing a switch; it does not require a large accumulation of substances. The key lies in the accuracy and efficiency of the signal transmission, rather than the absolute amount of raw materials.
MF of Glycine, glycyl-L-α-glutamyl-L-lysyl-
| CAS | 960608-17-7 |
| Molecular formula | C15H27N5O7 |
| Boiling point | 896.1±65.0 °C |
| Molecular weight | 389.4 |
Specification
| Item | Specification | Result |
| Appearance | White powder | Complies |
| Assay | ≥98.0% | 99.26% |
| Conclusion | Conform with enterprise specification | |
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FAQ:
Q1:Is glycine, glycyl-L-α-glutamyl-L-lysyl- safe?
Glycine, glycyl-L-α-glutamyl-L-lysyl- has been entered into the Japanese cosmetic ingredient directory, and the relevant safety assessment has been completed. It belongs to compliant skin conditioning raw materials. The addition ratio in actual formulas is generally not high, and it is often added to anti-aging essences, creams, and eye area skin care products for use.
Q2:Can sensitive skin use Tetrapeptide-21 USP/EP/BP?
According to the current safety assessment, it has a relatively low irritancy and is suitable for all skin types, including Asian sensitive skin. However, there may be individual differences. It is recommended to conduct a local test before the first use.
Q3:What layer of the skin does Tetrapeptide-21 USP/EP/BP mainly act upon?
It mainly targets the fibroblasts in the dermis and exerts its effect by influencing the activity of these cells.
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