Somatostatin Introduction
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Somatostatin Acetate is a growth inhibitory hormone, with the CAS number: 51110-01-1; molecular formula: C76H104N18O19S2; molecular weight: 1637.88; EINECS number: 256-969-7. Somatostatin is widely distributed in the central and peripheral nervous systems as well as the gastrointestinal tract. It is also present in the hearts of rats and humans. In the gastrointestinal mucosa, somatostatin is released by D cells, and its content is the highest in the antrum and body of the stomach. Somatostatin can regulate the secretion of digestive tract hormones, stabilize cell membranes, and play a protective role.
What is the mechanism of action of somatostatin?
Somatostatin Acetate is an artificially synthesized cyclic tetradecapeptide with a chemical structure and action mode consistent with that of the naturally occurring growth inhibiting hormone. Under physiological conditions, endogenous growth inhibiting hormone is mainly distributed in the hypothalamus and gastrointestinal tissues.
This active substance can reduce the secretion levels of growth hormone, thyroid stimulating hormone, insulin, and glucagon, as well as inhibit the production of gastric acid. It also has multiple effects on gastrointestinal peristalsis, nutrient absorption, visceral blood flow, and the body's nutritional metabolism.
Acetated Somatostatin can reduce the release of gastrin, gastric acid, and pepsin, thereby improving conditions related to upper gastrointestinal bleeding; it can significantly reduce blood flow in the internal organs, without causing significant fluctuations in systemic arterial blood pressure, and has application value for esophageal variceal bleeding.
Somatostatin can also inhibit the endocrine and exocrine activities of the pancreas and can be used for intervention in complications related to pancreatic surgery. Additionally, by regulating glucagon, it can also have an intervention effect on diabetic ketoacidosis.
What is the function of somatostatin?
Somatostatin is a naturally occurring polypeptide hormone that is widely distributed in the central nervous system and digestive system of the human body. Its core function is to act as an inhibitory regulatory factor for the body, exerting comprehensive regulatory and inhibitory effects on multiple endocrine and exocrine physiological activities.
From the perspective of its physiological mechanism, Somatostatin Acetate mainly functions by binding to specific G protein-coupled receptors in the body, effectively controlling the secretion of key endocrine hormones such as growth hormone, thyroid-stimulating hormone, insulin, and glucagon. It can also regulate the release of various gastrointestinal hormones such as gastrin and cholecystokinin. In addition, Somatostatin can reduce the secretion of gastric acid, pancreatic juice, and bile, slow down the rhythm of gastrointestinal peristalsis, and regulate the internal circulation state of the organs, participating in the functional regulation of the digestive and endocrine systems in an all-round way.
Based on these unique physiological characteristics, Somatostatin has extremely high research and application value. Synthetic analogues of artificial synthesized somatostatin can act in scenarios related to abnormal metabolism of limbs, abnormal neuroendocrine tissues, bleeding from abnormal blood vessels in the digestive tract, and pancreatic dysfunction.
Moreover, Somatostatin is also a key substance for maintaining the homeostasis of the human body. With its broad inhibitory regulatory ability, it can balance the metabolic operation of the body, inhibit abnormal cell proliferation, and stabilize neural signal transmission, serving as a "regulatory brake device" for the physiological system, ensuring the stable operation of multiple systems such as endocrine, digestion, and nerve.
MF of Somatostatin
| CAS | 51110-01-1 |
| Molecular formula | C76H104N18O19S2 |
| EINECS | 256-969-7 |
| Molecular weight | 1637.88 |
| Water solubility | Soluble in water (0.3 mg/ml) |
Specification
| Item | Specification | Result |
| Appearance | White powder | Complies |
| Identification | By IR | Complies |
| RT under chirality should complies | Complies | |
| Chloride: it gives a reaction of chloride | Complies | |
| Water | 3.0%~4.5% | 3.40% |
| Residue on Ignition | ≤0.2% | 0.08% |
| Heavy Metals | ≤10ppm | Complies |
| Related Substances | Individual Impurities:≤0.5% | 0.15% |
| Total Impurities:≤1.0% | 0.22% | |
| Residual Solvent | ≤0.06% | 0.0066% |
| ≤0.5% | 0.0150% | |
| ≤0.5% | 0.0013% | |
| Assay | ≥98.0% | 99.02% |
| Conclusion | Conform with enterprise specification | |
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FAQ:
Q1:What is the relationship between Somatostatin and Octreotide?
The latter is the artificial modification version of the former. Octreotide contains only 8 amino acids, but it has a stronger effect. In particular, it is more effective in inhibiting growth hormone and glucagon than natural Somatostatin, and its duration of action has been extended from a few minutes of the natural hormone to several hours.
Q2:What are the overall advantages of somatostatin application?
It is a multi-target balanced regulatory peptide that simultaneously takes into account endocrine regulation, gastrointestinal protection, blood flow regulation, and pancreatic stability. It has comprehensive effects, is suitable for a wide range of scenarios, and has high compatibility with the body. It is a highly valuable peptide raw material in the fields of metabolism and digestion.
Q3:Is there any difference between synthetic Somatostatin and natural somatostatin?
The structure, activity and mechanism of action are exactly the same. The synthetic version has higher purity and more stable batches, making it more suitable for scientific research and standardized application scenarios.
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