What is Rapastinel?
Xi'an Faithful BioTech Co., Ltd. is situated in Xi'an, the birthplace of the ancient Silk Road. Leveraging the city's mature logistics network and abundant fine chemical industrial resources, our enterprise has grown into an integrated fine chemical provider that delivers products to global partners. Rapastinel is a synthetically produced amidated tetrapeptide with the amino acid sequence Thr-Pro-Pro-Thr-NH₂. Its free base has CAS number 117928-94-6. It appears as a white to off-white powder with good water solubility; conventional research products show a purity of over 98% as determined by HPLC. This substance acts as a regulator of the glycine site of the NMDA receptor, possessing partial agonistic properties. Its molecular structure allows it to cross the blood-brain barrier and participate in the regulation of neuronal signaling pathways. It is primarily used in basic neuroscience research, particularly for laboratory studies related to receptor binding and neural plasticity.
Application of Rapastinel
Rapastinel (CAS 117928-94-6), as a synthetic peptide research reagent, is mainly used in laboratory research related to neuroscience. It can be used to explore the molecular and cellular mechanisms related to NMDA receptors, and is often used for experimental analysis in areas such as receptor binding characteristics, neuronal signaling pathways, and synaptic plasticity. It can help researchers observe changes in the expression of related signaling molecules and physiological changes at the synaptic level. It can also be used to explore the structure-function relationship of related peptide molecules, and provide experimental references for basic research on similar peptide compounds.
COA
| Test Item | Specification | Test Result |
| Appearance | White to off-white crystalline powder |
White crystalline powder |
| Purity(HPLC) | ≥98.0% | 99.21% |
| Water Content(Karl Fischer) |
≤2.0% | 0.85% |
| Residue on Ignition | ≤0.1% | 0.06% |
| Single Maximum Impurity | ≤1.0% | 0.32% |
| Total Impurities | ≤2.0% | 0.79% |
| Conclusion | Conform with enterprise specification | |
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Rapastinel has shown good overall tolerability in model organisms and early clinical trials. Its mechanism of action differs from that of similar NMDA receptor channel blockers. No typical mental or behavioral abnormalities or cognitive impairments were observed during the studies, indicating a relatively wide safety window.
Mechanism of action of Rapastinel
1. Specific targeting and regulation of NMDA receptors: Rapastinel specifically binds to the glycine site of the NMDA receptor on the neuronal cell membrane, partially activating the receptor and stabilizing its activity, preventing excessive opening or inhibition.
2. Mediating activation of downstream cellular signaling pathways: Rapastinel activates key signaling pathways such as ERK and mTOR within neurons, initiating multi-level intracellular signal transduction and regulating the basal metabolism and physiological activity of nerve cells.
3. Regulates the expression of neuroplasticity-related factors: Rapastinel can increase the expression levels of neurotrophic factors such as BDNF in the brain, contributing to synaptic remodeling, nerve cell repair and growth, and maintaining the homeostasis of nervous system plasticity.
4. Penetrates biological barriers to achieve central regulation: Rapastinel possesses excellent lipid-soluble structural properties, allowing it to penetrate the blood-brain barrier and directly act on central nervous tissue, achieving in-situ regulation of brain neural targets.
5. Optimizes synaptic transmission function: Rapastinel can fine-tune the efficiency of signal transmission between synapses, improve the information interaction state between neurons, and maintain the stable balance of the central nervous microenvironment.
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Shipping Methods
| Transportation Time | Shipping method | Cargo weight requirements | Advantage |
| 3-7 days | DHL,Germany DHL,Germany DPD, UPS,USPS,FedEx,TNT,EMS |
Suitable for under 50kg. International door to door express |
We have warehouses in Germany and California, USA, and customers in Europe and America can enjoy sending goods directly from these two places. |
| 7-15 days | By Air | Suitable for more than 50kg. fast and cheaper for large order |
|
| 15-60 days | By Sea | Suitable for more than 500kg. Cheapest shipping way |
FAQ
01. What are the molecular-level characteristics of Rapastinel?
Rapastinel can bind to corresponding receptor sites, mediating ERK and mTOR-related signaling pathways, influencing the expression of neurotrophic factors. Its molecular structure can also cross the blood-brain barrier, acting on central nervous system tissues.
02. In which research areas is Rapastinel primarily used?
Rapastinel is mainly used in basic neuroscience research, conducting laboratory-level experiments related to receptor binding validation, signaling pathway exploration, neural plasticity, and synaptic physiological characteristics.
03. What are the future development possibilities for Rapastinel?
In the short term, it will continue to exist as a target tool reagent, serving basic research and derivative molecule screening. If new derivative molecules are developed based on this framework, it may further increase the demand for raw materials.
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Disclaimer: All conventional products (non-customized products) pictures are taken in kind, but due to the influence of light (different time, different background light), shooting method, different display equipment parameters and other factors, there may be some differences between the picture and the real color, product color, please take the real effect prevail, product color difference is not a product quality problem.
Note: Always consult a qualified health practitioner before taking any new medication. This product is not intended to diagnose, treat, cure or prevent any disease.At the time of purchase, the international buyer agrees to assume the risk of all items arriving. We cannot replace lost or impounded items. Before sending items, you need to confirm that you agree to these terms.This is only a recommended dose based on our own experience and anecdotal evidence. We recommend that you do your own research before using this product.
Statement: This product is only used for scientific research, and the consequences of other uses are not responsible.
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