5 Amino 1mq Powder ​CAS 42464-96-0

5-Amino-1-methylquinolinium chloride Introduction

Xi'an Faithful BioTech Co., Ltd. is an export-oriented biotechnology and chemical trading company headquartered in Xi'an, Shaanxi Province, China. Founded in 2018, the company focuses on providing pharmaceutical intermediates, plant extracts, food additives, and feed ingredients to the global B2B market.

As a lean, professional supplier, we implement rigorous quality control to ensure batch stability and compliance. With an experienced international sales team, we offer highly competitive prices, reliable delivery times, and one-stop export services.

Our products are widely supplied to the pharmaceutical, health supplement, cosmetic, and feed industries in Europe, North America, Southeast Asia, and the Middle East.

Nicotinamide N-methyltransferase (NNMT) is an enzyme that in humans is encoded by the nnmt gene. Its CAS number: 42464-96-0; Molecular formula: C10H11N2.I; Molecular weight: 286.11; EINECS Number: 464-196-0.It can selectively bind the residue of nnmt substrate binding site. 5 amino 1mq powder ​can promote the differentiation of myoblasts in vitro and enhance the fusion and regeneration ability of muscle stem cells in aged mice. Therefore, researchers believe that: human embryonic stem cells expression of NNMTi is believed to help maintain the cells in a naive state. In addition, It is also considered as a new idea to solve the problem of obesity and thus induce various complications.

Click email：sales6@faithfulbio.com Or WhatsApp：+86 17782780648

What is the latest research success of 5 Amino 1mq Powder ​for obesity and related diseases?

Obesity is a serious and increasingly serious global health problem, with few effective treatments available. Compared with simply improving diet, the combination of 5-Amino-1methylquinolinium iodide therapy and dietary replacement methods can accelerate and improve weight and fat loss, increase the ratio of lean body mass to body weight, reduce the weight of white adipose tissue in the liver and epididymis, reduce liver obesity, and improve liver steatosis. Importantly, the combination of the two can normalize body composition and liver obesity parameters. NNMT catalyzes the methylation of nicotinamide and similar compounds using the methyl donor S-adenosyl methionine (SAM-e) to produce S-adenosyl-L-homocysteine (SAH) and 1-methylnicotinamide.. These substances exhibit unique metabolomic features in adipose tissue, primarily increasing the abundance of ketogenic amino acids and altering metabolites associated with energy metabolism pathways. In summary, the addition of 5-Amino-1-methylquinolinium strongly supports its potential as a treatment for obesity and obesity related comorbidities by regulating body weight, obesity, liver physiology, and adipose tissue metabolome.
In addition, NNMTi can enhance strength and promote the regenerative ability of aging muscles, providing a promising treatment for sarcopenia. Research has shown that treatment with 5-amino-1MQ powder not only promotes quantifiable improvement in lipid content within muscle cells, but also significantly increases gastrocnemius muscle fibers when combined with exercise. In addition, Methylation of nicotinamide by NNMT and SAM-e is the major pathway for degradation of nicotinamide leading to excretion in the urine.

What are the relevant studies on the anti-aging effect of 5 Amino 1mq Powder?

According to relevant reports, NNMT is an enzyme overexpressed during skeletal muscle aging, which is associated with repairing damage to the NAD+pathway, dysregulation of sirtuin1 activity, and increased aging of muscle stem cells. It has been confirmed that treatment with NNMT inhibitors (NNMTi) will rescue age-related deficiencies in muscle stem cell activity, thereby promoting excellent regeneration after aging muscle injury. In addition, researchers have always believed that cancer is a manifestation of aging and a necessary feedback for the failure of bodily mechanisms. And currently, the scientific community is gradually accepting NNMT is a biomarker of cancer.NNMT expression is significantly upregulated in many cancers, including pancreatic cancer where levels of NNMT enzyme correlate with increased risk of death.The cause of these correlations has not been established, but may be related to the fact that NNMT enzyme is an inhibitor of DNA repair.In the study of mice,5 Amino 1mq Powder and 1-methylnicotinamide inhibit autophagy in breast cancer, protecting breast cancer cells against oxidative stress.

What is the effect of 5-Amino-1-methylquinolinium chloride on the liver?

5 amino 1mq powder, as a selective inhibitor of NNMT enzyme, is the main site of its metabolic transformation in the liver, and the liver itself also expresses the NNMT protein. Under animal experimental conditions, this substance can inhibit the NNMT activity within the liver, reduce the extensive methylation consumption of Nicotinamide, help maintain the NAD⁺ level in liver tissue, to a certain extent improve mitochondrial fatty acid oxidation, alleviate the excessive accumulation of lipids in the liver, and observe that liver steatosis has been alleviated in the high-fat diet-induced model. 5 Amino 1mq Powder mainly relies on the CYP enzymes in the liver for metabolism, and the metabolites are excreted from the body through the kidneys. The current animal experiments have not observed obvious liver damage signals, but the relevant data are limited to preclinical studies and lack human-related verification. It can only be used for scientific research exploration and cannot be directly equivalent to having a regulatory effect on human liver.

A variety of shipping methods for you to choose

Our strengths:

Our company has passed FDA and ISO19001 quality management system certification. And we have internal cooperation agreements with multiple factories and laboratories in China,Our company can provide 5 amino 1mq powder etc. at a more favorable price. If you are interested, please leave a message.
We not only have unique advantages in transportation, but also support multiple payment methods, whether you use US dollars, euros, Australian dollars, or local currencies from Singapore, Malaysia, Thailand, and so on. We can also support local currencies in these regions and countries. In addition, we also support bank cards (credit cards, etc.) for payments.

FAQ:

Q1:What are the limitations of this molecular experiment?
Most of the data come from animal models, and there are differences in metabolism among species. There is no unified standard for the optimal dosage, and the effects on humans cannot be simply extrapolated.
Q2:How is the security performance?

The current short-term animal experiments have not revealed any obvious liver damage signals, but there is a lack of complete human toxicological data, and the risks associated with high-dose and long-term use have not yet been clarified.

Q3:Why can the NAD⁺ level be improved after inhibiting NNMT?

NNMT continuously consumes nicotinamide in the body and accelerates its methylation metabolism. After 1MQ inhibits the enzyme activity, the excessive consumption of nicotinamide is reduced, and more raw materials can be used for the synthesis of NAD⁺, helping to maintain the NAD⁺ reserve in the tissues.

Disclaimer: The information published on this website comes from the internet, which does not mean that this website agrees with its views or confirms the authenticity of the content. Please pay attention to distinguish it. In addition, the products provided by our company are only used for scientific research. We are not responsible for the consequences of any improper use.

If you are interested in our products, or have critical suggestions on our articles or are not completely satisfied with the products received

Click email：sales6@faithfulbio.com Or WhatsApp：+86 17782780648

Hot Tags: 5 amino 1mq powder ​cas 42464-96-0, China, suppliers, manufacturers, factory, customized, wholesale, buy, price, bulk, pure, producer, discount, for sale, in stock, free sample, raw powder, raw material, made in China