LZ1 Peptide

LLZ1 Peptide is an antibacterial peptide composed of 15 amino acids, also called LZ1 antibacterial peptide. Its amino acid sequence is: Val-Lys-Arg-Trp-Lys-Trp-Arg-Lys-Trp-Lys-Trp-Val-NH (single-letter sequence: VKRWKKWWRKWKKWV-NH₂ The polypeptide is white solid powder, the purity is usually ≥95% or 98%, and the storage condition is -20℃. Related research shows that LZ1 polypeptide sequence is rich in positively charged amino acid residues, such as lysine (Lys) and arginine (Arg), and tryptophan (Trp) with special structure. These amino acids are linked by peptide bonds to form a linear structure, which may form secondary structures such as α-helix or β-sheet in certain circumstances. The positively charged amino acid residues in its molecules help to interact with negatively charged bacterial cell membranes, which plays a key role in its biological functions such as antibacterial.

What are the latest research advances on the pharmacological mechanism of action of LZ1 Peptide?

LZ1 polypeptide has a broad application prospect in the medical field because of its unique antibacterial, anti-inflammatory and antimalarial properties. It is expected to become an important drug candidate for the treatment of malaria and other infectious diseases in the future. Our company will combine the latest research on polypeptide technology to explain its internal mechanism:
1.What is its antibacterial mechanism? ​
The LZ1 peptide binds to negatively charged bacterial cell membranes through electrostatic attraction, and subsequently destroys the integrity of the cell membrane through various means, such as forming transmembrane ion channels, leading to increased membrane permeability, ion and small molecule efflux from the cell, and ultimately causing bacterial death. In addition, LZ1 peptides may also enter bacterial cells and interfere with key metabolic processes, such as inhibiting enzyme activity related to energy metabolism, protein synthesis, or nucleic acid synthesis, hindering bacterial growth and reproduction.
2.What is its anti malaria mechanism of action? ​
LZ1 peptide can effectively inhibit the growth of Plasmodium falciparum, with an IC50 value of 3.045 μ M. Research has found that LZ1 peptide can selectively inhibit the activity of pyruvate kinase in red blood cells infected with malaria parasites, specifically suppressing the production of adenosine triphosphate (ATP). Due to ATP being a direct energy source for cellular life activities, inhibition of ATP production can affect the survival and reproduction of malaria parasites in red blood cells. In in vivo experiments, LZ1 peptide exhibited significant antimalarial activity in a dose-dependent and time-dependent manner.
3.What is its anti-inflammatory mechanism? ​
LZ1 peptide can inhibit the secretion of inflammatory factors including tumor necrosis factor - α (TNF - α) and interleukin (IL) -1 β, thereby improving inflammation caused by pathogens such as Streptococcus acnes. The specific signaling pathway regulation mechanism is not fully understood, and it is speculated that it may affect the inflammatory signaling pathway inside the cell by binding to certain receptors on the cell surface, thereby reducing the production and release of inflammatory factors.

What are the application prospects of LZ1 peptide?

LZ1 peptide API powder has multiple biological activities:
1.Antibacterial activity: It has strong antibacterial activity against common acne pathogens such as Propionibacterium acnes, Staphylococcus epidermidis, and Staphylococcus aureus, with a low minimum inhibitory concentration (MIC), demonstrating strong antibacterial ability.
2.Anti inflammatory effect: It can inhibit the secretion of inflammatory factors such as TNF - α and IL-1 β, and improve the inflammatory response.
Anti malaria activity: It can effectively inhibit the growth of Plasmodium falciparum, with an IC50 value of 3.045 μ M.
3.Antitumor activity: In the study of pancreatic cancer, LZ1 polypeptide can inhibit the invasion of pancreatic cancer cells, and has no significant effect on angiogenesis. It is a candidate drug molecule for the treatment of pancreatic cancer. ​
Because of its unique antibacterial, anti-inflammatory, anti malaria, and anti-tumor properties, it has shown broad application prospects in the medical field. It is expected to become an important drug candidate for the treatment of malaria and other infectious diseases in the future. In addition, LZ1 peptide can also be used in combination therapy with traditional antimalarial drugs to enhance efficacy and reduce drug resistance; Improve targeting and stability through nanocarrier or liposome encapsulation; As antibacterial agents or anti infective coating materials (such as surface treatment of medical devices), new ideas for future anti-tumor targets.

What are the applications of LZ1 peptide in the field of skincare products?

LZ1 peptide has almost no cytotoxicity towards human keratinocytes, almost no hemolytic activity towards human red blood cells, and is very stable in human plasma. Its small molecular structure and high purity (95%) make LZ1 peptide easily soluble in water and have a wide antibacterial spectrum, with almost no hemolytic activity or eukaryotic cytotoxicity, and high safety. In addition, due to its structure and characteristics of small molecules being easily soluble in water, it has advantages in practical applications such as preparing water-based skincare products and pharmaceutical preparations. Our LZ1 API peptide is often designed to improve skin wrinkles, moisturization, and softness, and is provided in freeze-dried powder form. Therefore, it also has potential application value in the field of skincare products.
Meanwhile, it may also have some solubility in some commonly used organic solvents such as dimethyl sulfoxide (DMSO), but when using organic solvents for dissolution, its potential impact on biological activity and safety and compatibility in subsequent application scenarios need to be considered.

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Our company has passed FDA and ISO19001 quality management system certification. And we have internal cooperation agreements with multiple factories and laboratories in China,Our company can provide  LZ1 peptide powder etc. at a more favorable price. If you are interested, please leave a message.
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FAQ:

Q1: What are the storage conditions for LZ1 peptide pharmaceutical raw materials? ​
LZ1 peptide raw powder should be stored at -20 ℃, away from light, moisture, and sealed dry. The product is usually valid for 2 years, as specified in the product manual.
Q2: What is the dissolution method of LZ1 peptide? ​
LZ1 peptide is easily soluble in water, it is recommended to dissolve it in physiological saline. If organic solvents are required, dimethyl sulfoxide (DMSO) can be chosen, but attention should be paid to the potential impact of organic solvents on biological activity. After dissolution, it should be used as soon as possible to avoid repeated freezing and thawing.
Q3: What is the recommended concentration for LZ1 peptide? ​
The concentration of LZ1 peptide used depends on the specific application scenario. In the field of skincare products, it is recommended to use a concentration of 0.1% -0.5%; In the field of medical research, the concentration used can be determined based on experimental design, usually gradually optimized starting from low concentrations. The specific concentration for use should refer to the product manual or consult a professional.
Q4: What are the characteristics of LZ1 peptide compared to other peptides such as LL37 and Cecropins? ​
Compared with other known antimicrobial peptides such as LL37 and Cecropins, LZ1 peptide has differences in amino acid composition and mechanism of action. LZ1 peptide, with its unique chemical properties, exhibits excellent characteristics in water solubility, stability, etc., making it more flexible and convenient in practical applications. In addition, LZ1 peptide also has anti malaria activity, which is a characteristic that other antimicrobial peptides do not possess.

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