CETRORELIX ACID Introduction
Xi'an Faithful BioTech Co., Ltd. (est. 2018, Xi'an) is a B2B supplier of pharmaceutical intermediates, plant extracts, food additives, and feed ingredients to global markets.
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Cetrorelix Acid is an artificially synthesized ten-peptide compound that belongs to the class of gonadotropin-releasing hormone antagonists. CAS Number: 120287-85-6; Molecular formula: C70H92ClN17O14 Molecular weight: 1431.04 EINECS Number: 686-384-6.This product can rapidly inhibit the secretion of luteinizing hormone (LH) by competitively binding to the GnRH receptors in the pituitary gland, thereby achieving the regulation of endogenous reproductive hormone levels. In the field of assisted reproduction, Cetrorelix is mainly used to control the ovarian stimulation cycle by inhibiting the premature LH peak, in order to prevent the premature expulsion of follicles and obtain mature oocytes. Moreover, studies have shown that it also has potential application value in the treatment of hormone-sensitive tumors (such as prostate cancer, breast cancer, ovarian cancer, etc.) and related disease models.
How does CETRORELIX ACID inhibit luteinizing hormone?
Cetrorelix inhibits the secretion of luteinizing hormone (LH) by competitively binding to the gonadotropin-releasing hormone (GnRH) receptors in the pituitary gland. Its molecular structure is similar to that of natural GnRH and can occupy the receptor binding site with a higher affinity before others do, but it does not activate the downstream signaling pathways. This "occupy without activating" characteristic effectively blocks the LH production instructions issued by the brain, preventing the pituitary gland from releasing LH. Due to its direct action on the target, CETRORELIX ACID takes effect rapidly and can significantly reduce LH levels within a short period of time. This inhibitory effect is reversible, and once the product is discontinued, the pituitary gland function can return to normal. Therefore, in the assisted reproductive cycle, this product is used to prevent the premature appearance of LH peaks, thereby avoiding the premature release of follicles and ensuring that the oocytes can mature.
The role and mechanism of action of CETRORELIX ACID in assisted reproduction
During the oocyte stimulation cycle in assisted reproduction, upon stimulation by the oocyte stimulation conditions, the follicles gradually develop. The body may spontaneously reach a peak of luteinizing hormone, leading to premature ovulation and interfering with the prearranged egg retrieval schedule. Cetrorelix is mainly used to inhibit this sudden hormone peak, preventing the premature release of follicles and ensuring the continuous development of the follicles, allowing the egg retrieval work to proceed as planned.
Cetrorelix acid belongs to a competitive antagonistic peptide for GnRH receptors. It can preferentially bind to the GnRH receptors on the pituitary gland, blocking the binding of endogenous signaling molecules to the receptors, blocking the downstream hormone release pathway, and rapidly inhibiting the abnormal increase of luteinizing hormone. This substance does not cause an initial hormone rebound phenomenon. While controlling the risk of ovulation, it does not interfere with the normal development process of the follicles.
MF of CETRORELIX ACID
| CAS | 120287-85-6 |
| Molecular formula | C70H92ClN17O14 |
| Molecular weight | 1431.04 |
| EINECS | 686-384-6 |
| Melting point | >259°C (dec.) |
| density | 1.42±0.1 g/cm3(Predicted) |
Specification
| Item | Specification | Result |
| Appearance | white powder | Complies |
| Identification | Infrared spectroscopy (IR)/(UV) matches the standard | Complies |
| Assay (HPLC) | 98.0-102.0% | 99.65% |
| Residue on Ignition | ≤0.1% | 0.05% |
| Loss on drying | ≤ 0.5% | 0.25% |
| Heavy metals | ≤20ppm | 12ppm |
| Individual Impurity (HPLC) | ≤2.0% | 1.30% |
| Total impurities (HPLC) | ≤5.0% | 2.12% |
| Microbial limit | < 1000cfu/g | 400 cfu/g |
| Microbial limit | < 100cfu/g | 30cfu/g |
| Microbial limit | Absence of Escherichia coli, Salmonella spp., and Staphylococcus aureus | Not detected |
| Bacterial Endotoxins | LAL Test ≤0.25 Endotoxin Units/mg | 0.15 EU/mg |
| Conclusion | Conform with enterprise specification | |
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A variety of shipping methods for you to choose
| Transportation Time | Shipping method | Cargo weight requirements | Advantage |
| 3-7 days | DHL,Germany DHL,Germany DPD, UPS,USPS,FedEx,TNT,EMS |
Suitable for under 50kg. International door to door express |
We have warehouses in Germany and California, USA, and customers in Europe and America can enjoy sending goods directly from these two places. |
| 7-15 days | By Air | Suitable for more than 50kg. fast and cheaper for large order |
|
| 15-60 days | By Sea | Suitable for more than 500kg. Cheapest shipping way |
Our strengths:
Our company has passed FDA and ISO19001 quality management system certification. And we have internal cooperation agreements with multiple factories and laboratories in China,Our company can provide Cetrorelix etc. at a more favorable price. If you are interested, please leave a message.
We not only have unique advantages in transportation, but also support multiple payment methods, whether you use US dollars, euros, Australian dollars, or local currencies from Singapore, Malaysia, Thailand, and so on. We can also support local currencies in these regions and countries. In addition, we also support bank cards (credit cards, etc.) for payments.
FAQ:
Q1:CETRORELIX ACID and Ganirelix are both GnRH antagonists. What is the core difference between them?
Both are third-generation GnRH antagonistic peptides; the former has stronger metabolic stability and a longer half-life, supporting the use of a single high-dose administration; the latter has a shorter half-life and can only be used at low doses daily; the amino acid sequences of the two are different, and their impurity profiles and synthesis processes are also distinct. Therefore, they cannot be directly substituted for each other in experiments.
Q2:How long does it take for the pituitary function to recover after using CETRORELIX ACID?
The recovery time is related to the rate of product metabolism and individual differences. Generally, the pituitary gland can resume its normal response to GnRH within a short period after discontinuation (ranging from several days to several weeks).
Q3:Does CETRORELIX ACID have a direct impact on follicle development itself?
It does not directly act on the follicles. Instead, it indirectly influences the maturation and release of the follicles by regulating the LH secretion of the pituitary gland, thus providing sufficient time for follicle development.
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