Biphalin Trifluoroacetate Salt CAS 83916-01-2

Biphalin trifluoroacetate salt CAS 83916-01-2 is a highly active synthetic opioid peptide agonist, a dimeric enkephalin analog. It is often formulated as a trifluoroacetate to enhance water solubility and stability, and is a core tool compound in neuropharmacology, pain mechanisms, and neuroprotective research. This substance is a white lyophilized powder with a research-grade purity typically ≥97% (HPLC). It must be stored at -20°C in a dry, light-protected environment to ensure structural and activity stability.

Its molecular structure contains two enkephalin pharmacophores, allowing it to bind simultaneously with high affinity to μ, δ, and κ opioid receptors at nanomolar levels. Its analgesic potency is significantly higher than morphine, exhibiting potent analgesic effects in animal models of acute pain, neuropathic pain, and chronic pain, with a superior duration of action. In addition to its analgesic properties, Biphalin trifluoroacetate salt also exhibits clear neuroprotective activity. In models of cerebral ischemia, stroke, and excitotoxicity, it effectively reduces infarct volume, alleviates cerebral edema, and inhibits neuronal apoptosis. Its protective effect can be blocked by the opioid receptor antagonist naltrexone, suggesting that its action depends on the opioid receptor pathway. Simultaneously, this substance also possesses multiple biological effects, including anti-inflammatory, immunomodulatory, antiproliferative, and antiviral properties. It can inhibit the release of pro-inflammatory factors such as TNF-α and IL-1β, and regulate central and peripheral inflammatory responses.