What is ALPHA-MSH Peptide?
ALPHA-MSH Peptide specifically refers to its C-terminal tripeptide fragment α-MSH (11-13), with the sequence Lys-Pro-Val (KPV). It is a white to off-white lyophilized powder, CAS number 67727-97-3. This product is the C-terminal active tripeptide fragment of α-melanocyte-stimulating hormone. As an endogenous neuroimmunomodulatory peptide, the KPV fragment retains the core anti-inflammatory activity of the full-length α-MSH, but with a shorter sequence, it has better blood-brain barrier penetration. ALPHA-MSH Peptide mainly acts on multiple aspects such as anti-inflammation, neuroprotection, antibacterial activity, and antipyresis, and has broad application value in immunomodulation research, neurological disease models, and anti-infection research.
How does ALPHA-MSH Peptide achieve neuroimmune regulation and anti-inflammation?
The applications of ALPHA-MSH Peptide are primarily concentrated in basic scientific research and drug development. In anti-inflammatory and immunomodulatory studies, this peptide is widely used in various inflammatory models. In experiments, systematic use of KPV significantly reduced the accumulation of polymorphonuclear leukocytes in the peritoneal cavity, demonstrating a clear anti-inflammatory effect. In neuroprotective studies, ALPHA-MSH Peptide exerts neuroprotective effects in traumatic brain injury models by inhibiting microglial overactivation and reducing neuronal apoptosis. In antibacterial studies, this peptide also shows certain biological activity against bacterial infections. In antitumor studies, full-length α-MSH analogs, due to their high affinity for the MC1R receptor highly expressed in melanoma cells, are being explored as a novel strategy for radionuclide-targeted therapy of metastatic melanoma.
How to construct an anti-inflammatory and repairing pharmacological system using ALPHA-MSH Peptide?
After entering the body, ALPHA-MSH Peptide specifically targets the melanocortin receptor family, blocking the overactivation of the NF-κB inflammatory signaling pathway and significantly downregulating the release of pro-inflammatory factors such as TNF-α and interleukins. This reduces local redness, swelling, and chronic inflammatory infiltration at the source, achieving a mild systemic anti-inflammatory effect. When acting on epidermal melanocytes, it can weakly activate MC1R receptors to regulate melanin synthesis, aiding in the physiological repair of pigmented skin. Simultaneously, it accelerates the orderly metabolism of stratum corneum cells, strengthens the skin barrier structure, and reduces oxidative damage from external stimuli.
Compared to full-length α-MSH peptides, ALPHA-MSH Peptide is more resistant to in vivo peptidase hydrolysis, exhibiting stronger metabolic stability and less likely to cause adverse effects such as appetite and metabolic disorders. It can be used alone to prepare topical skin repair preparations and anti-inflammatory injectable peptide raw materials, or it can be combined with antioxidant and soothing active ingredients, covering three major pharmacological applications: inflammation intervention, skin barrier maintenance, and pigment metabolism regulation.
MF of ALPHA-MSH Peptide
Molecular Formula: C16H30N4O4
Molecular Weight: 342.43 g/mol
Precision quality: 342.2318 Da
Sequence: H-Lys-Pro-Val-OH
PH: 4.2~5.3
Product Specification
| Item | Specification | Result |
| Appearance | White to off-white lyophilized powder | Complies |
| Identification | IR/HPLC consistent with standard | Complies |
| Assay | ≥98.0% | 99.26% |
| Purity | ≥98.0% | 98.76% |
| Loss on Drying | ≤5.0% | 2.14% |
| Water Content | ≤ 5.0% | 3.20% |
| Heavy Metals | ≤ 20 ppm | Complies |
| Conclusion | Complies with enterprise standard | |
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FAQ：
Q1: What are the advantages of ALPHA-MSH Peptide compared to full-length α-MSH?
A1: The short-chain tripeptide structure exhibits stronger resistance to enzymatic degradation, a longer in vivo half-life, retains only anti-inflammatory and skin-repairing activities, does not interfere with appetite or energy metabolism, has higher safety profile, and better storage stability.
Q2: Which types of inflammation does ALPHA-MSH Peptide primarily target?
A2: It primarily inhibits chronic inflammation and allergic redness on the skin surface. It can also be used to regulate low-grade systemic inflammation in vivo, reducing the outbreak of inflammatory factors by blocking classic inflammatory pathways. Its target is precise and gentle.
Q3: Which dosage forms are suitable for ALPHA-MSH Peptide?
A3: With excellent water solubility, it can be used to develop transdermal gels, serums, and also lyophilized injectable formulations and oral sustained-release peptide formulations. It has strong formulation compatibility and is less complex to develop.
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