Choline Glycerophosphate Cas 28319-77-9
Product Name:Choline glycerophosphate
Synonym:L-α-Glycerophosphocholine;α-GPC;Choline Alfoscerate;cholini alfosceras;sn-Glycero-3-phosphocholine;alfoscerate de choline;L-a-GPC
CAS NO.:28319-77-9
EINECS NO.:248-962-2
Molecular Formula:C8H20NO6P
Purity & Grade: 99%; Medicine grade
Character:White Powder
Free sample:Available
Stock:In stock
Warehouse: USA/EU/AU Warehouse
MOQ & Package: 10g; Package according to demand
Shipping: Safe and fast delivery
Lead Time: 7-15 days
Store & Shelf life: Cool & dry place; 24 months
Description
Product description

Choline glycerophosphate(GPC) is a water-soluble small molecule substance that exists normally in the human body and is the biosynthetic precursor of the important neurotransmitter Acetylcholine. The most important role of GPC lies in the fact that the choline it produces is a water-soluble B vitamin, which plays a significant role in the brain and nervous system. Research shows that GPC is crucial for the production of certain hormones and neurotransmitters such as Acetylcholine, thereby supporting the functions of the brain and nervous system.
Choline glycerophosphate is not only one of the main osmotic substances of renal medullary cells, but also can parallently change the concentration of osmotic substances inside and outside the cells. This is beneficial for the health of cerebral blood vessels, especially for behavioral and emotional disorders caused by brain decline. Choline glycerophosphate has the potential to treat and prevent a variety of biochemical lesions. Researchers have found that it can alter the structure of phosphate lipid compounds in the membranes of neurons, and have discovered that it has a peculiar effect in relieving physical tension among the related factors that cause neurodegenerative syndrome.
Choline glycerophosphate is an intermediate of phospholipid metabolism that exists naturally in the human body. It is present in cells and throughout the human body. Structurally, it is composed of choline, glycerol and phosphoric acid. It is a major preservation form of choline and is recognized as a source of choline. Because it is an endogenous substance, its toxic and side effects are extremely low. After absorption, Choline glycerophosphate is decomposed into choline and glycerophosphate under the action of enzymes in the body. Among them, choline participates in the biosynthesis of acetylcholine, which is a kind of neurotrigger neurotransmitter. Glycerophosphate is the precursor of lecithin and participates in its synthesis. The main pharmacological effects include protecting the metabolism of choline, ensuring the synthesis of acetylcholine and lecithin in the nerve membrane, and improving blood circulation. To improve cognitive and behavioral responses in patients with brain capillary nerve damage.

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COA
| ltems | Standard | Results |
| Appearance | White powder,neutral odor, highly hygroscopic |
Conforms |
| Identification | TLC:Standard solution and test solution same spot,RF |
Conforms |
| Specific Optical | -2.4°~-2.8° | -2.744° |
| Heavy metals(as PB) | <10ppm | Conforms |
| Sulfate(SO4) | ≤0.02% | Conforms |
| Chloride(CI) | ≤0.02% | Conforms |
| Phosphate | ≤5ppm | Conforms |
| pH | 4.5~7.0 | 5.91 |
| Related substance | Spot not bigger than standard solution spot |
No spot |
| Residual solvent | <0.5% | Conforms |
| Water Content | <2.0% | 0.42% |
| Assay(dried basis) | 98.0%--102.0% | 100.52% |
| Conclusion | Conform with enterprise specification | |
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Melting point: -98 ° C
Molecular formula: C8H20NO6P
Molecular weight: 257.221
Flash point: 11 °C
Accurate mass: 257.102814
PSA 108.86000
LogP -5.63
Is Choline Glycerophosphate the same as choline?
Choline glycerophosphate is a chemical made in the body from choline. It is also made in a lab and used in dietary supplements. Alpha-GPC seems to increase the levels of a chemical in the brain called acetylcholine. This brain chemical is important for memory and learning functions.
Does Choline Glycerophosphate increase dopamine?
Clinical trials evaluating the effects of alpha-GPC treatment in patients with Alzheimer's disease indicated an increase in dopamine levels and dopamine active transporter expression in the frontal cortex and cerebellum. This treatment also enhanced serotonin levels in the frontal cortex and striatum of rat brains.
Can Choline Glycerophosphate cause insomnia?
Alpha-GPC seems to be safe when used appropriately. It can cause side effects in some people including heartburn, headache, insomnia, dizziness, skin rash, and confusion.
The efficacy and function of Choline Glycerophosphate
Due to its structural characteristics, Choline glycerophosphate (GPC) contributes to the synthesis of phospholipids in cell membranes, thereby enhancing the fluidity of cell membranes. At the same time, it also has a positive impact on lipid metabolism.
Choline glycerophosphate (GPC) can cross the blood-brain barrier and provide raw materials for the synthesis of the neurotransmitter acetylcholine, thereby increasing the level of acetylcholine in the hippocampus, effectively improving the choline status of the human body, and supporting the functions of the brain and nervous system by increasing the formation of nerve cells and reducing the death of neurons. Enhance the cognitive ability of the brain.
Choline glycerophosphate (GPC) can increase the expression level of genes and prevent the decline in cognitive function caused by aging. This also makes GPC have obvious effects in the treatment of mental disorders such as Alzheimer's disease, amnesia, and cerebral ischemic stroke.
Furthermore, some preliminary evidence suggests that choline glycerophosphate (GPC) can enhance the production.
The increase in growth hormone production and power output can enhance muscle mass and improve overall metabolic activity, thereby improving body composition.
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Transportation Time |
Shipping method |
Cargo weight requirements |
Advantage |
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3-7 days |
DHL,Germany DHL,Germany DPD, |
Suitable for under 50kg. |
We have warehouses in Germany and California, USA, and customers in Europe and America can enjoy sending goods directly from these two places. |
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By Air |
Suitable for more than 50kg. |
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By Sea |
Suitable for more than 500kg. |
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