Product description
Tocofersolan (abbreviated as TPGS) is a water-soluble derivative of vitamin E, formed by the reaction of the carboxyl group of vitamin E succinate ester with the hydroxyl group of polyethylene glycol. Because it contains both the vitamin E lipophilic group and the hydrophilic long chain of polyethylene glycol, it has better surfactant properties and water solubility, which can significantly increase the absorption of poorly soluble drugs in the gastrointestinal tract and improve bioavailability.
In recent years, many studies have found that TPGS, in addition to being used as a pharmaceutical excipient, also has many unique properties, such as being used as an absorption enhancer and a multidrug resistance reversal agent, etc. TPGS can also be applied to precursor drugs, micelles, liposomes, and TPGS-copolymer carriers to improve the solubility, permeability and stability of preparations. Thereby achieving sustained, controlled release and targeted effects, and promoting the absorption of the drug.
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COA
| ltems | Standard | Results |
| Description | Off-white or yellowish waxy solid | Conforms |
| Identification | Meets the requirements | Conforms |
| (D-a-tocopherol)Assay | ≥25.0% | 28.20% |
| Solubility in water | 20% Min (Clear solution) | Conforms |
| Acidity | ≤0.27mL | 0.20mL |
| Specific Rotation | ≥+24.0° | +26.5° |
| Heavy metals | ≤10ppm | < 10ppm |
| Cadmiu | ≤ 1ppm | < 0.01ppm |
| Arseni | ≤ 1ppm | < 0.040ppm |
| Lead | ≤ 3ppm | < 0.1ppm |
| Mercur | ≤ 0.1ppm | < 0.010ppm |
| Residual solvents | ethyl acetat ≤3000ppm | Not Detected |
| ethanol ≤5000ppm | 23ppm | |
| Total Plate Count | ≤1000CFU/g | < 10CFU/g |
| Yeast & Mold | ≤100CFU/g | < 10CFU/g |
| Salmonella | Negative | Negative |
| E.Coli | Negative | Negative |
| Conclusion | Conform with enterprise specification | |
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Density: 1.01g/cm ³
Boiling point: 662.7 ° C at 760mmHg
Melting point: 34-38ºC
Molecular formula: C35H58O6
Molecular weight: 574.83
Flash point: 195.4ºC
PSA 100.52000
LogP 8.38890
What is tocofersolan used for?
Tocofersolan is a derivative of alpha tocopherol used to treat vitamin E deficiencies. D-Alpha-tocopheryl polyethylene glycol 1000 succinate (Tocofersolan, Vedrop), has been developed in Europe as an orally bioavailable source of vitamin E in children suffering from cholestasis.
What does TPGS mean?
An intriguing commercial material is tocopheryl polyethylene glycol succinate (TPGS). TPGS is synthesized from the lipid-soluble antioxidant, α-tocopherol (vitamin E) by grafting to a polyethylene glycol (PEG) oligomer through a succinate diester linker.
What is the TPGS form of vitamin E?
TPGS, a water miscible form of vitamin E, is composed of a hydrophobic vitamin E part and a hydrophilic PEG chain. It exhibits excellent drug delivery capability based on this special amphiphilic structure.
Application
Tocofersolan is now widely used in the research of formulations, serving as a solubilizer, absorption enhancer, emulsifier, plasticizer, and carrier for water-insoluble or liposoluble drug delivery systems, such as solid dispersions, carriers for ocular administration, and carriers for intranasal administration.
In many countries, Tocofersolan is now widely used in the research of formulations, serving as a solubilizer, absorption enhancer, emulsifier, plasticizer, and carrier for water-insoluble or liposoluble drug delivery systems, such as solid dispersions, carriers for ocular administration, and carriers for intranasal administration. In recent years, many studies have found that TPGS, in addition to being used as a pharmaceutical excipient, also has many unique properties, such as being used as an absorption enhancer and a multidrug resistance reversal agent, etc. TPGS can also be applied to precursor drugs, micelles, liposomes, and TPGS-copolymer carriers to improve the solubility, permeability and stability of preparations. Thereby achieving sustained, controlled release and targeted effects, and promoting the absorption of the drug.
Reduce the particle size of anti-tumor drugs; Increase the drug loading capacity of nanoparticles and improve their stability; Increase the Zeta potential.
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why choose us
Our Factory
Package
Shipping Methods
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Transportation Time |
Shipping method |
Cargo weight requirements |
Advantage |
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3-7 days |
DHL,Germany DHL,Germany DPD, |
Suitable for under 50kg. |
We have warehouses in Germany and California, USA, and customers in Europe and America can enjoy sending goods directly from these two places. |
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7-15 days |
By Air |
Suitable for more than 50kg. |
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15-60 days |
By Sea |
Suitable for more than 500kg. |
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