L Histidine Hydrochloride CAS 1007-42-7

L Histidine hydrochloride powder can be used for biochemical research, as well as for the processing of pharmaceutical raw materials and food additives. High quality L-histidine dihydrochloride is a white crystalline substance that is easily soluble in water and can be used as a pharmaceutical intermediate to synthesize other products. In clinical practice, it is often used as an adjuvant therapy for peptic ulcers. However, for cardiovascular diseases such as anemia, angina pectoris, aortitis, and heart failure, due to the slow synthesis of natural L-Histidine in the human body, this product is often used as a quasi essential amino acid in postoperative patient food. In addition, L-histidine dihydrochloride raw material is often seen in infant and toddler food.

Why haven't there been manufacturers in China that use microbial fermentation to produce L-histidine on a large scale?

L-histidine hydrochloride raw powder is a common alkaline amino acid in the market. It is also an urgently needed amino acid variety in the market and one of the four amino acids that affect China's goal of achieving complete localization of amino acid infusion raw materials.

At present, the industrial production of L-histidine hydrochloride in China is mainly extracted from the hydrolysate of pig blood powder. However, this method has low yield, high difficulty in extraction, and complex processes, resulting in high production costs and extremely high environmental costs. The production of L-histidine hydrochloride by microbial fermentation method has the advantages of mild production control conditions, low production cost, no environmental pollution, and low extraction difficulty. Developing new control processes to improve L-histidine fermentation units is of great significance for enhancing China's competitiveness in the international market.

Using Serratia marcescens for L-histidine hydrochloride fermentation, as the bacterial concentration increases, the bacterial body produces proteoglycan byproducts that are secreted to the extracellular environment. The fermentation broth becomes increasingly viscous, affecting oxygen mass transfer, and the utilization rate of dissolved oxygen decreases. This leads to a slower growth rate of L-histidine, a longer fermentation cycle, a lower sugar acid conversion rate, and a viscous fermentation broth that greatly affects the extraction process. This is the bottleneck for the production of L-histidine by this bacterium.

How To Reduce The Viscosity Of L-Histidine Hydrochloride Fermentation Broth?

Researchers have proposed a method to reduce the viscosity of L-histidine fermentation broth. L histidine hydrochloride powder is produced by fermenting with Serratia marcescens, and potassium chloride with a final concentration of 5-15 g/L is added to the fermentation medium. At the same time, sterile trypsin solution is added during the fermentation process to make the final concentration of trypsin 0.1-1.0 g/L, and then mixed fermentation is carried out.

What are the benefits of this method?

This method uses viscous Serratia marcescens fermentation to produce L-histidine. During the fermentation process, high concentrations of potassium chloride are added while sterile trypsin solution is added to solve the problem of viscosity in the feed solution. By adding high concentrations of potassium chloride, the bacterial permeate is increased. Adding trypsin not only reduces the content of extracellular proteoglycans in the fermentation solution, improves viscosity and dissolved oxygen, but also hydrolyzes the protein to generate various amino acids that can be reused by the bacterial cells, effectively increasing the L histidine hydrochloride powder fermentation unit from 30g/L to 45g/L. Improved unit output and reduced difficulty in post extraction work, resulting in low production costs.

A variety of shipping methods for you to choose

Our strengths:

Our company has passed FDA and ISO19001 quality management system certification. And we have internal cooperation agreements with multiple factories and laboratories in China,Our company can provide L Histidine Hydrochloride powder etc. at a more favorable price. If you are interested, please leave a message.
We not only have unique advantages in transportation, but also support multiple payment methods, whether you use US dollars, euros, Australian dollars, or local currencies from Singapore, Malaysia, Thailand, and so on. We can also support local currencies in these regions and countries. In addition, we also support bank cards (credit cards, etc.) for payments.

Disclaimer: The information published on this website comes from the internet, which does not mean that this website agrees with its views or confirms the authenticity of the content. Please pay attention to distinguish it. In addition, the products provided by our company are only used for scientific research. We are not responsible for the consequences of any improper use.

If you are interested in our products, or have critical suggestions on our articles or are not completely satisfied with the products received, please contact us by Email ：sales6@faithfulbio.com   . Our team is committed to ensuring the complete satisfaction of customers.

Hot Tags: l histidine hydrochloride cas 1007-42-7, China, suppliers, manufacturers, factory, customized, wholesale, buy, price, bulk, pure, producer, discount, for sale, in stock, free sample, raw powder, raw material, made in China