What is k2mk7 vitamin?
k2mk7 vitamin is also called menadione, which is a fat-soluble vitamin and one of the indispensable vitamins for human body. In human body, it is mainly synthesized by intestinal bacteria, and also exists in some animal meat products and fermented products, such as animal liver, fermented dairy products and cheese, among which natto is the most abundant source. As an auxiliary factor of γ -glutamine carboxylase, k2mk7 vitamin can activate a variety of vitamin K-dependent proteins and play a key role in cardiovascular and bone health.
| Product name | k2mk7 vitamin |
| CAS | 2124-57-4 |
| Molecular formula | C46H64O2 |
| Molecular weight | 649 |
| melting point | 54 °C |
| boiling point | bp0.0002 200° (some dec) |
| density | 0.961 |
| stability | Sensitive to light and temperature |
| Storage condition | -20°C |
What is the origin and history of k2mk7 vitamin?
In modern diet, the average intake of vitamin K2 is very low, and it mostly exists in fermented foods, such as tofu, milk and natto.
In the large family of vitamins, vitamin K belongs to a relatively late discovery. In 1929, Danish scientist Henrik Dam discovered and extracted vitamin K from animal liver and hemp seed oil, and speculated that it was an effective component to prevent bleeding. In 1939, he purified vitamin K1 from green leafy vegetables.In 1943, the Nobel Prize in Physiology or Medicine was awarded to Henrik Dam and Edward Adalbert doisy, praising their contributions to vitamin K. However, due to people's limited knowledge of vitamin K at that time, scientists could not distinguish between vitamin K1 and k2mk7 vitamin, so they classified them as vitamin K.
This cognitive limitation led to vitamin K2 being forgotten for decades. In 1975, the difference between vitamin K2 and vitamin K1 was paid attention to, which led scientists to study k2mk7 vitamin deeply. Traditionally, vitamin K is considered as an important component of blood coagulation. Without it, we may continue to bleed because of minor wounds. In fact, this is only the function of vitamin K1, and it does not represent the function of the whole vitamin K family. All structural forms of K vitamins are based on menadione structure, which can be divided into K1, K2, K3 and so on according to the length and position differences of side chains. The subtle differences in the side chain structure of vitamins K1 and K2 make their efficacy very different.
What is the physiological function and function of k2mk7 vitamin?
1. Anti-osteoporosis. Its function is to activate matrix osteocalcin. Under its function, after matrix osteocalcin is activated, many calcium binding sites are formed on the protein, and this activated calcium binding site can follow up the calcium binding in the bone. After the active site is combined with calcium ions in the bone, the physiological osteogenesis process is completed, so that the human bone is hard and can support the weight. Without k2mk7 vitamin, matrix osteocalcin can't be activated, calcium can't combine with osteocalcin, and bone can't really form, so calcium will be lost. The lost calcium enters many other organs of the body and deposits in the organs, which will lead to calcification of organs and cause many diseases, so it is of special significance for calcium fixation in bone and osteoporosis. The control experiment also found that taking its supplement can slow down the age-related decline of bone mineral density. In addition, Japanese research also found that it reduced 60% of spinal fractures, 77% of hip fractures and 81% of non-spinal fractures.
2. Improve dental health. One of the main regulatory proteins of dental health is osteocalcin, which is a protein vital to bone metabolism and can be activated by k2mk7 vitamin. Dentin is calcified tissue under enamel on teeth, and osteocalcin can trigger the mechanism of stimulating the growth of new dentin.
3. Help to fight cancer. It can negatively regulate tyrosine kinase and phosphatase activities related to cell carcinogenesis, and regulate regulatory factors related to cell proliferation, which eventually leads to the cell cycle of tumor cells inhibiting tumor growth.
4. Improve diabetes. k2mk7 vitamin can up-regulate insulin gene, promote islet β cells, release insulin, improve the metabolic level of the body, and contribute to the rehabilitation of diabetic patients.
Product Specification
| Item | Specifications | Result |
| Appearance | Crystalline powder | Organoleptic |
| Color | Pale yellow or white | Visual |
| Purity (HPLC,Menaquinone-7) | >1.3% (13000ug/g) | 1.32% |
| Pharm.excipient(Carbohydrate) | 90.0% | 90.6% |
| PH | 5.5-8.0 | conforms |
| Heavy metals | Lead≤0.5 mg/kg | <0.5 mg/kg |
| Cadmium≤0.5 mg/kg | <0.5 mg/kg | |
| Arsenic≤0.5 mg/kg | <0.5 mg/kg | |
| Mercury≤0.1 mg/kg | <0.1 mg/kg | |
| Microbial limit | Total Aerobic Microbial Count: NMT 100 CFU/g | <100 CFU/g |
| Total Yeasts and Moulds Count: NMT 10 CFU/g | <10 CFU/g | |
| E.Coli: Negative | Negative | |
| Salmonella: Negative | Negative | |
|
S.Aureus: Negative |
Negative | |
| Conclusion: The test results are conformed to the in-house specification | ||
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Attention: It should be noted that this product is not intended for the diagnosis, treatment, cure, or prevention of any disease. Please consult your doctor and learn about available research before use. Please do not use without authorization. This compound can only be used for research purposes. The US Food and Drug Administration has not evaluated these claims.
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