Product description
Tropisetron hydrochloride API CAS 105826-92-4 is a potent and selective 5-HT3 receptor antagonist used to prevent and treat nausea and vomiting induced by radiotherapy and chemotherapy. Its indications have now expanded to include the prevention and treatment of nausea and vomiting in children undergoing radiotherapy and chemotherapy, and the prevention and treatment of postoperative nausea and vomiting in adults. Tropisetron hydrochloride's greatest advantages are its proven efficacy, good tolerability, few adverse reactions, and ease of use.
Tropisetron hydrochloride primarily inhibits the vomiting reflex by selectively blocking presynaptic 5-HT receptors on peripheral neurons. Additionally, its antiemetic effect may also be related to its direct blocking of central 5-HT receptors, thereby inhibiting vagal nerve stimulation in the final region.
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COA
| Tests | Specifications | Results |
| Assay | 95.0%~100.0% | 99.60% |
| Appearance | white powder | white powder |
| Identification | Positive | Positive |
| Loss on Drying | 0.09% | 0.2% max |
| Chloride | ＜0.010% | 0.011%max |
| Sulphate | ＜0.010% | 0.014%max |
| Ammonium Salt | ＜0.020% | 0.02% max |
| Residue on Ignition | 0.06% | 0.01%max |
| Heavy Metals | ＜8ppm | 20ppm max |
| Arsenic | ＜1ppm | 2ppm max |
| Easily carbonizable substances | colorless | No color develops |
| Total Plate Count | 50/g | NMT 1000/g |
| Mold | ＜10/g | NMT 100/g |
| Yeast | ＜10/g | NMT 100/g |
| Coliforms | Not found | Negative |
| Salmonella | Not found | Negative |
| Conclusion | Conform with enterprise specification | |
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Boiling point: 448.5ºC at 760 mmHg
Melting point: 283-285ºC
Molecular formula: C17H21ClN2O2
Molecular weight: 320.814
Flash point: 225ºC
Exact mass: 320.129150
PSA: 41.90000
LogP: 2.83000
Pharmacological Actions of Tropisetron hydrochloride API CAS 105826-92-4:
Peripheral Actions: Blocks 5-HT₃ receptors at the vagal nerve endings in the gastrointestinal tract, inhibiting the vomiting reflex induced by the release of 5-HT from enterochromaffin cells stimulated by chemotherapy products.
Central Actions: Blocks 5-HT₃ receptors in the final medulla oblongata (vomiting center), directly inhibiting vomiting signal transduction.
Characteristics: Duration of action for 24 hours, once daily; no extrapyramidal side effects.
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Package
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Transportation Time |
Shipping method |
Cargo weight requirements |
Advantage |
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3-7 days |
DHL,Germany DHL,Germany DPD, |
Suitable for under 50kg. |
We have warehouses in Germany and California, USA, and customers in Europe and America can enjoy sending goods directly from these two places. |
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7-15 days |
By Air |
Suitable for more than 50kg. |
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15-60 days |
By Sea |
Suitable for more than 500kg. |
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FAQ
01. What are the differences between Tropisetron hydrochloride API CAS 105826-92-4 and Ondansetron and Granisetron?
As 5-HT₃ receptor antagonists, Tropisetron hydrochloride has a longer half-life and is more convenient with once-daily administration.
02. What are the common adverse reactions of Tropisetron hydrochloride API CAS 105826-92-4?
Headache, dizziness; constipation, fatigue, abdominal pain. These are mostly mild to moderate and transient.
03. Where can I buy Tropisetron hydrochloride API CAS 105826-92-4?
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