Stavudine powder is a white solid nucleoside analogue, which is a nucleoside reverse transcriptase inhibitor related to thymidine. It is transformed into triphosphate in cells in stages, which can terminate the DNA synthesis of retrovirus (including inhibiting HIV reverse transcriptase). In addition, pure Stavir can also be used as an intermediate in organic synthesis and medical chemistry for the synthesis of bioactive molecules and antiviral small molecular inhibitors.
| Molecular formula |
|
|
|
Item |
Standard |
Test Results |
|
Appearance |
White or off-white powder |
white powder |
|
Identification |
The retention time of the major peak of the assay preparation corresponds to that of the standard preparation, as obtained in the assay. |
99.50% |
|
Solubility |
Easily soluble in water, slightly soluble in ethanol (96%), and slightly soluble in dichloromethane. It shows polymorphism (5.9) |
Conforms |
|
Loss on Drying |
≤1.00% |
0.21% |
|
Heavy Metals |
≤ 10ppm |
(Pb)0.08 ppm |
|
Sulfated Ash |
≤ 0.10% |
0.03% |
|
Total plate count |
≤1000 CFU/g |
2.8 CFU/g |
|
Yeast&Mold |
≤50 CFU/g |
0.8 CFU/g |
|
Related Substances |
Impurity A: ≤0.30% |
0.18% |
|
Other unknown impurity: ≤0.10% |
0.07% |
|
|
Total Impurities: ≤0.50% |
0.42% |
|
|
Residual Solvent |
Methylbenzene≤0.089% |
Conforms |
|
Ethyl acetate≤0.5% |
Conforms |
|
|
n-Heptane≤0.5% |
Conforms |
|
|
Assay |
Calculated as anhydrous, the content of C10H12N2O4 should be 98.0%~102.0% |
98.8% |
| Conclusion： |
Conform with enterprise specification . |
What are nucleoside reverse transcriptase inhibitors like stavudine?
The common nucleoside reverse transcriptase inhibitors in our life are stavudine, zidovudine, lamivudine, abacavir and other products.
1. Stavudine powder: This product is a thymidine analogue that is converted into triphosphate Stavudine by cellular enzymes in the body. The latter competes with triphosphate deoxythymidine to inhibit HIV reverse transcriptase, thereby inhibiting virus replication; And terminate the elongation of DNA strands to inhibit the synthesis of viral DNA. In addition, sitagliptin triphosphate can inhibit the DNA polymerase β and γ of host cells and reduce the synthesis of mitochondrial DNA;
2.Zidovudine powder: After entering host cells, this product is phosphorylated and converted into the active form of triphosphate, zidovudine. The latter competitively inhibits the activity of HIV virus reverse transcriptase and acts on the early stage of HIV virus replication, inhibiting the synthesis, transport, and integration of viral DNA into the host cell nucleus, thereby inhibiting virus replication. Long term use can easily lead to drug resistance, which is caused by mutations in certain amino acids in the reverse transcriptase molecule of the virus, resulting in the inability of the drug to bind to it and take effect;
3.Lamivudine powder: This product is the first oral medicine approved for the treatment of chronic hepatitis B in the world. It can effectively treat HBV infection and is also used for the treatment of HIV infection. It is absorbed quickly after oral administration, with a bioavailability of 80%, an average plasma half-life of 9 hours, and 70% is excreted in urine in its original form. About 5% is metabolized into inactive trans sulfoxide metabolites;
4. Abacavir powder: This product absorbs rapidly, with an absolute bioavailability of approximately 83% for the finished product. The plasma protein binding rate is about 50%. The apparent distribution volume is 0.86L/kg. Mainly distributed in extravascular areas, this product is a new carbocyclic 2-deoxyguanosine nucleoside drug that is converted into the active metabolite Abacavir triphosphate by cellular enzymes in vivo, inhibiting HIV reverse transcriptase.
 |
||
| naturally exist in organisms |
no bone aggregation no bone marrow suppression |
bone aggregation marrow suppression |
A variety of shipping methods for you to choose
|
Transportation Time |
Shipping method |
Cargo weight requirements |
Advantage |
|
3-7 days |
DHL,Germany DHL,Germany DPD, |
Suitable for under 50kg. |
We have warehouses in Germany and California, USA, |
|
7-15 days |
By Air |
Suitable for more than 50kg. |
|
|
15-60 days |
By Sea |
Suitable for more than 500kg. |
Our strengths:
Our company has passed FDA and ISO19001 quality management system certification. And we have internal cooperation agreements with multiple factories and laboratories in China,Our company can provide Stavudine powder etc. at a more favorable price. If you are interested, please leave a message.
We not only have unique advantages in transportation, but also support multiple payment methods, whether you use US dollars, euros, Australian dollars, or local currencies from Singapore, Malaysia, Thailand, and so on. We can also support local currencies in these regions and countries. In addition, we also support bank cards (credit cards, etc.) for payments.
Disclaimer: The information published on this website comes from the internet, which does not mean that this website agrees with its views or confirms the authenticity of the content. Please pay attention to distinguish it. In addition, the products provided by our company are only used for scientific research. We are not responsible for the consequences of any improper use.
If you are interested in our products, or have critical suggestions on our articles or are not completely satisfied with the products received, please contact us by Email ：sales6@faithfulbio.com . Our team is committed to ensuring the complete satisfaction of customers.
Hot Tags: stavudine powder cas 3056-17-5, China, suppliers, manufacturers, factory, customized, wholesale, buy, price, bulk, pure, producer, discount, for sale, in stock, free sample, raw powder, raw material, made in China