Product description

Roflumilast Powder is a selective phosphodiesterase 4(PDE4) inhibitor in the benzamide group. By selectively inhibiting PDE4, it blocks the transmission of inflammatory response signals, thereby inhibiting the damage to lung tissue caused by respiratory diseases such as COPD and asthma. It has been shown to inhibit COPD associated inflammation in a novel mode of action.
Its unique properties help to better manage patients with COPD: When used in combination with a bronchodilator to treat the most severe COPD patients, Roflumilast offers the additional benefit of further reducing symptoms and the rate of disease progression, making it the first drug to target a specific type of COPD patients with severe airflow restriction associated with prolonged cough and phlegm and a history of recurrent disease progression.

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COA
| ltems | Standard | Results |
| Appearance | White crystal powder | conform |
| Formula | C17H14CI2F2N203 | conform |
| Mass | 403.207 | 402.035 |
| Purity | ≥99% | 99.30% |
| Log P | 5.1039 | conform |
| PSA | 60.45 | conform |
| Density | 1.471 g/cm3 | conform |
| Vapor pressure | 1.28E-07mmHg at 25°C | conform |
| Boiling point | 430.6'℃ at 760 mmHg | conform |
| Melting point | 158℃ | conform |
| Flash point | 214.2℃ | conform |
| Conclusion | Conform with enterprise specification . | |
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What kind of drug is roflumilast?
Roflumilast is used in people with severe chronic obstructive pulmonary disease (COPD; a group of diseases that affect the lungs and airways) to reduce the number of episodes or worsening of COPD symptoms. Roflumilast is in a class of medications called phosphodiesterase inhibitors.
What is the mechanism of action of roflumilast?
The molecular mechanism of action of roflumilast is inhibition of the PDE4 isoenzyme with a consequent increase of cyclic adenosine monophosphate. Roflumilast evidently has several pharmacological effects: antiinflammatory, anti-emphysema, and antibiotic actions.
Why is roflumilast used in COPD?
Roflumilast Powder is a PDE4 inhibitor with demonstrated efficacy for improving lung function and decreasing exacerbations in patients with severe to very severe COPD associated with chronic bronchitis.
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Package

Shipping Methods
|
Transportation Time |
Shipping method |
Cargo weight requirements |
Advantage |
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3-7 days |
DHL,Germany DHL,Germany DPD, |
Suitable for under 50kg. |
We have warehouses in Germany and California, USA, and customers in Europe and America can enjoy sending goods directly from these two places. |
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7-15 days |
By Air |
Suitable for more than 50kg. |
|
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15-60 days |
By Sea |
Suitable for more than 500kg. |
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