Palmatine Hydrochloride CAS 10605-02-4

What is Palmatine hydrochloride?

Palmatine hydrochloride is an isoquinoline alkaloid compound, its English name derived from plants of the genus "Stephania" in the palm family. This substance is widely found in medicinal plants such as "Coptis chinensis", and has structural characteristics similar to berberine and purslane, but it has not been found in "Ranunculus spp" .

Palmatine HCL is a typical isoquinoline alkaloid, mainly found in the rhizomes of natural Chinese herbal medicines such as "Phellodendron chinense", "Coptis chinensis", "Smilax china", and "Nandina domestica", and is an effective component in traditional Chinese medicine. It possesses pharmacological effects such as clearing heat and detoxifying, and antibacterial, antiviral, and antifungal effects. Additionally, Palmatine chloride also exhibits certain antitumor activity, strongly inhibiting oxygen uptake by mouse ascites cancer cells.   

Its hydrochloride and hydroiodide derivatives are used in pharmaceutical testing, for example, in the determination of "Coptis chinensis" capsule components using high-performance liquid chromatography (HPLC). Studies show that the recovery rate of palmatine hydrochloride in traditional Chinese medicine extraction can reach over 97%, and it serves as a key indicator in the quality analysis of products such as rotundine. This compound is often detected in conjunction with other components such as total alkaloids from Coptis chinensis, and is also involved in pharmacological studies related to colon and cholinesterase.

contact us by Email ：sales6@faithfulbio.com

How effective is palmatine chloride in colon cancer photodynamic therapy?

Palmatine hydrochloride  is a natural active component derived from traditional Chinese medicine. Firstly, the absorption and fluorescence spectra of PaH were measured using UV-Vis spectrophotometer and RF-1500PC spectrophotometer respectively. The amount of oxygen free radicals (¹O₂) generated by PaH was measured using the DPBF method. The black toxicity of PaH was evaluated using the MTT method. The absorption rate of PaH by HT-29 cells was measured at various time intervals. The location of PaH within HT-29 cells was observed using a confocal laser fluorescence microscope. The photodynamic treatment was performed by exposing HT-29 cells cultured with PaH to visible light (470 nm) emitted from an LED light source. After 24-hour photodynamic treatment, the phototoxicity was evaluated using the MTT method. After 18-hour photodynamic treatment, cell apoptosis was observed using the Alexa Fluor 488/PI double staining cell analysis. The results showed that PaH exhibited absorption peaks in the 400-500 nm visible light region and fluorescence peaks at 406 nm in the 365 nm range. PaH was activated by the 470 nm visible light emitted from the LED light source and generated hydrogen peroxide (¹O₂). In the cancer toxicity test, no cell toxicity was observed in HT-29 cancer cells and normal NIH-3T3 cells after 24-hour treatment with PaH alone. After 40 minutes of cultivation, the cell absorption of PaH reached its maximum, and PaH was localized in the mitochondria. The photodynamic treatment showed significant phototoxicity in HT-29 cells, especially in cells treated with PaH. As the concentration and light intensity increased, cell apoptosis increased significantly. Additional analysis showed that when the photodynamic treatment was performed at a concentration of 5 μM and an energy density of 10.8 J/cm², the initial and late cell apoptosis rates of HT-29 cells increased significantly to 21.54% and 5.39%, respectively. These results indicate that the natural photogenerating agent, phenylmethylsulfonate, has promising application potential in photodynamic therapy for squamous cell carcinoma.

 

What are the pharmacological potential and mechanism of action of Palmatine hydrochloride?

Pharmacological potential

Neuroprotection and Alzheimer's Disease: This technology can control tau protein aggregation, showing promising potential for treating Alzheimer's disease.

Gastrointestinal Health: Palmatine HCL has a significant protective effect against gastric ulcers and gastric inflammation by regulating gut microbiota, inhibiting the production of inflammatory cytokines, and modulating the metabolism of triterpenoids.

Anti-inflammatory and Metabolic Support: PALMATINE CHLORIDE is a potent immunomodulator that can regulate metabolic disorders and may contribute significantly to the treatment of diabetes.

Positive effect: According to studies within the body, Palmatine hydrochloride interacts with GABAA receptors and can shorten the onset time of sleep and prolong the duration of sleep.

Key Mechanisms of Action

Multifaceted signal regulation: Echinomaritin regulates key signaling pathways such as NF-κB/NLRP3, Nrf2/HO-1, AMPK/mTOR, thereby demonstrating anti-inflammatory and anti-oxidative effects.
Neurotransmitter regulation: PALMATINE CHLORIDE can activate GABAergic and serotonergic pathways, potentially resulting in calming and anti-depressive effects.
Autophagy regulation: Activates the AMPK/mTOR pathway to promote the removal of damaged cellular organelles through autophagy.
DNA interaction: Palmatine chloride possesses the characteristics of DNA hybridization binding, and this contributes to anti-tumor activity.

MF of Palmatine hydrochloride

Melting point	205℃
Molecular formula	C21H22ClNO4
Molecular weight	387.86
Solubility	Soluble in chloroform (a little) and DMSO (a little)
Storage conditions	Hygroscopic, Refrigerator, under inert atmosphere

Specification

A variety of shipping methods for you to choose

Our strengths:

Our company has passed FDA and ISO19001 quality management system certification. And we have internal cooperation agreements with multiple factories and laboratories in China,Our company can provide Palmatine hydrochloride  etc. at a more favorable price. If you are interested, please leave a message.
We not only have unique advantages in transportation, but also support multiple payment methods, whether you use US dollars, euros, Australian dollars, or local currencies from Singapore, Malaysia, Thailand, and so on. We can also support local currencies in these regions and countries. In addition, we also support bank cards (credit cards, etc.) for payments.

FAQ:

Q1: What is PalMatin hydrochloride used for?
PALMATINE CHLORIDE can be used for the following purposes: introducing carbon chains into glycosphingolipid galactosylceramides via stereoselective olefin cross-condensation; and generating monoacylglycerols and 1,3-symmetric triacylglycerols via regioselective ring-opening reactions of ethylene oxide.
Q2: Is PalMatin hydrochloride just salt?
Palmatin hydrochloride is a typical inorganic salt, appearing as thin, sticky yellow solid, primarily existing as a stable hydrate. It is highly hygroscopic, rapidly absorbing moisture from the air. Its natural resources are abundant, including seafloor magnesium deposits, ordinary seawater, and underground brine. Due to its good water solubility and mature chemical properties, Palmatine chloride has wide applications in industry, environmental science, food processing, and consumer chemicals.
Q3: Who should avoid using Palmatine hydrochloride ?

Patients with severe renal impairment , myasthenia gravis, cardiac conduction block, or active gastrointestinal obstruction should avoid using Palmatine HCL . Patients with renal disease should be regularly monitored and take magnesium supplements under the guidance of a physician.

Disclaimer: The information published on this website comes from the internet, which does not mean that this website agrees with its views or confirms the authenticity of the content. Please pay attention to distinguish it. In addition, the products provided by our company are only used for scientific research. We are not responsible for the consequences of any improper use.

If you are interested in our products, or have critical suggestions on our articles or are not completely satisfied with the products received, please contact us by Email ：sales6@faithfulbio.com   .  Our team is committed to ensuring the complete satisfaction of customers.

Hot Tags: palmatine hydrochloride cas 10605-02-4, China, suppliers, manufacturers, factory, customized, wholesale, buy, price, bulk, pure, producer, discount, for sale, in stock, free sample, raw powder, raw material, made in China