NAD Raw Powder CAS 53-84-9

NAD raw powder CAS 53-84-9, or NAD+, is a chemical substance and coenzyme found in all living cells. It consists of two nucleotides linked by a phosphate group; each nucleotide is composed of an adenine base and a nicotinamide base. It is the energy source for hundreds of metabolic processes in the human body, participating in maintaining mitochondrial function, DNA repair, antioxidation, and various physiological activities. NAD+ is a key substance for slowing down aging and plays an irreplaceable role in the body. The level of NAD+ in the body determines the rate of aging. Alterations in NAD+ homeostasis can be found in almost all age-related diseases, including neurodegenerative diseases, diabetes, and cancer. Therefore, the higher the NAD+ level, the younger and healthier the cells, tissues, and the entire body will be. Furthermore, scientists have discovered that a safe and effective way to increase NAD+ levels is nicotinamide riboside, or NR, a precursor to NAD+ and another form of vitamin B3. It participates in the catabolism of compounds such as cells, proteins, carbohydrates, and fats, and can improve cardiovascular and brain health, enhance fat metabolism, aid in detoxification and beauty, and slow down aging.

What are the underlying mechanisms behind NAD's anti-aging effects?

One reason for aging is DNA damage. Gray hair and organ decline, such as ovarian aging, are related to DNA damage. Lack of sleep and high stress levels exacerbate DNA damage.

Research has found that NAD helps activate the PARP1 gene (acting as a first responder, detecting DNA damage and then promoting the selection of repair pathways. PARP1 improves repair efficiency by causing chromatin decompression through ADP ribosylation of histones and by interacting with and modifying various DNA repair factors). This repairs DNA damage and promotes the triggering of metabolic shifts.

In short, NAD+ can directly and indirectly affect many key cellular functions, including metabolic pathways, DNA repair, chromatin remodeling, cellular senescence, and immune cell function, thereby slowing down the aging process.