2- Thiourea pyrimidine is a sulfhydryl uracil derivative, and its pure product is white-like or white powder. Often used in pharmaceutical industry, electroplating industry. In the pharmaceutical industry, 2-Thiouracil is an established antithyroid raw material.
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Structure: |
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Item |
Specification |
Results |
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Appearance |
White powder |
White powder |
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Assay |
≥99.0% |
99.73% |
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Individual impurity |
≤0.5% |
0.11% |
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Loss on drying |
≤0.5% |
0.12% |
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Sulphated ash |
≤0.5% |
0.15% |
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Heavy metals |
≤25ppm |
Conforms |
| Conclusion |
The batch is in compliance with Enterprise grade. |
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What are the medical uses of 2- thiouracil?
2- Thiourea pyrimidine has long existed in the seeds of Brassica and Crucifera species. It is a uracil analogue, and its oxygen atom at the 2 nd position has been replaced by sulfur atom, which has been used to treat diffuse toxic goiter. Its mechanism is to inhibit thyroid activity by blocking thyroid peroxidase. However, at present, few people use 2-Thiouracil as a therapeutic product against thyroid, coronary vasodilation and congestive heart failure, but switch to a safer product. Now the main research direction is to use this product as a selective inhibitor of neuronal nitric oxide synthase.
What are the methylation reactions of 2-thiouracil?
Suspend a mixture of 2-thiouracil (12.8 g) and fine powdered sodium hydroxide (4.3 g) in water (35 mL) in a dry reaction flask, and then heat the resulting reaction mixture to 60-70 ° C until the solid dissolves. Then add ethanol (70 mL) to the mixture and cool the resulting reaction solution to around 30 ° C. Add 6.3 mL of iodomethane to the mixture. Heat the solution again to 50-60 ° C and keep it in that environment while stirring for about 20 minutes. Monitor the reaction progress through TLC spot plates. After the raw materials in the reaction system have completely reacted, cool the reaction mixture to room temperature, and then filter and collect the precipitated white solid. The obtained reaction mixture can be purified by recrystallization from ethanol to obtain the methylated target product molecule.
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Transportation Time |
Shipping method |
Cargo weight requirements |
Advantage |
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3-7 days |
DHL,Germany DHL,Germany DPD, |
Suitable for under 50kg. |
We have warehouses in Germany and California, USA, |
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7-15 days |
By Air |
Suitable for more than 50kg. |
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15-60 days |
By Sea |
Suitable for more than 500kg. |
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