Raw powder Vincristine Sulphate is a chemical substance with molecular formula C46H56N4O10H2SO4, molecular weight 923.04, CAS: 2068-78-2, white or off-white crystalline powder, odorless. It is wet and easy to turn yellow when exposed to light and heat. Melting point 218 ~ 220℃, soluble in methanol, ethanol, DMSO, and other organic solvents, from Catharanthus roseus. Used in biochemical research and tumor research. Monoamine oxidase inhibition. Study on the impedance of multiple drugs.
What is Vincristine Sulphate?
Raw powder Vincristine Sulphate is a cell cycle-specific antitumor drug of Catharanthus roseus alkaloid, which has been widely used since it came out in 1962. Anti-tumor target is microtubules, which mainly inhibit the polymerization of tubulin, thus affecting the formation of spindle microtubules and stopping mitosis in metaphase. Like other Catharanthus roseus alkaloids, VCR has a good therapeutic effect on many malignant tumors of lymphoid tissues, including invasive non-Hodgkin's lymphoma and acute lymphoblastic leukemia. Mainly used in the clinical treatment of acute leukemia, malignant lymphoma, and other diseases.
Vincristine sulfate is a kind of dimeric indole alkaloid extracted from the leaves of the Apocynaceae plant Changchun.
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Real shot pictures of Vincristine sulfate powder | Vincristine sulfate structure diagram |
How does Vincristine Sulphate work?
The anti-tumor target of Raw Powder Vincristine Sulphate is microtubules., which mainly inhibits the polymerization of tubulin and affects the formation of spindle microtubules so that mitosis stops at metaphase. CHOP (cyclophosphamide [C]+ doxorubicin [H]+ vincristine [O]+ prednisone [P]) is a clinically recognized standard nursing scheme for the first-line treatment of CD30 positive mature T cell lymphoma (MTCL). Vincristine sulfate can stop cell division in the metaphase. Like colchicine, vincristine sulfate can bind tubulin to inhibit its biological activity, but its binding site is different, and its effect is stronger than colchicine, and its curative effect is about 10 times higher than that of vincristine. In 2019, the sales market of terminal anti-tumor and immunomodulators in public hospitals in key provinces and cities exceeded 45 billion yuan, an increase of 16.37% over the previous year. Vincristine sulfate is the main anti-myeloma drug at present.
Where does Vincristine Sulphate apply?
1. Acute leukemia, especially children's acute leukemia, has a remarkable curative effect on acute lymphoblastic leukemia.
2. Malignant lymphoma.
3. Germ cell tumors.
4. Small cell lung cancer, Ewing's sarcoma, nephroblastoma, and neuroblastoma.
5. Breast cancer, chronic lymphocytic leukemia, digestive tract cancer, melanoma, multiple myeloma, etc.
What are the side effects of vincristine sulfate?
The main side effects of vincristine sulfate are peripheral neuropathy, hyponatremia, constipation, and alopecia.
Peripheral neuropathy can sometimes reach a very serious level, so when this side effect occurs or is likely to occur, we must avoid, reduce or stop using vincristine. One of the first symptoms is foot drop. Therefore, patients with a family history of foot drop or progressive nervous peroneal muscular atrophy had better have a genetic test before using vincristine.
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Note: This compound should be used for research purposes only. These claims have not been evaluated by the Food and Drug Administration. Please consult your doctor and learn about available studies before using them. This product is not intended to diagnose, treat, cure or prevent any disease.
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