Lapatinib Ditosylate powder is a chemical substance with the formula: C41H40ClFN4O11S3, molecular weight: 925.46, boiling point: 750.7°C at 760 mmHg, flash point: 407.8 C. It can improve the physical solubility of lapatinib and bioavailability of Lapatinib Ditosylate to some extent. Based on Lapatinib, the second innovation of Lapatinib Ditosylate increased the action intensity of lapatinib xylene sulfonate.
What is Lapatinib Ditosylate?
Lapatinib Ditosylate powder is used to sensitize cancer cells overexpressing HER2 to radiation, and to perform chemotherapy on tamoxifen and trastuzumab-resistant cell lines. It blocks signal transduction through Akt and MAPK pathways, which leads to a decrease in cell survival rate. In drug-resistant cancer cells, trastuzumab inhibits HER2 phosphorylation, prevents ubiquitination of receptors, and leads to the accumulation of inactive HER2 dimers on the cell surface.
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Real shot pictures of Lapatinib Ditosylate raw powder | Lapatinib Ditosylate structure diagram |
How does Lapatinib Ditosylate work?
Lapatinib Ditosylate powder is used in combination with capecitabine for the treatment of over-expressed advanced or metastatic breast cancer, which has been previously treated with anthracycline, paclitaxel, and trastuzumab.
People who should not use Lapatinib ditosylate?
As Lapatinib ditosylate is a drug metabolized by the liver CYP enzyme system, we must pay attention to the dosage adjustment when using other drugs that can induce or inhibit CYP enzyme. Generally, pregnant women should not use it, because its pregnancy toxicity is classified as D. Therefore, it is not recommended for pregnant women or those who are pregnant if there is no absolute need or great benefit to the mother.
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A variety of shipping methods for you to choose
Transportation Time | Shipping method | Cargo weight requirements | Advantage |
3-7 days | DHL,Germany DHL,Germany DPD, | Suitable for under 50kg. | We have warehouses in Germany and California, the USA, |
7-15 days | By Air | Suitable for more than 50kg. | |
15-60 days | By Sea | Suitable for more than 500kg. |
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Note: This compound should be used for research purposes only. These claims have not been evaluated by the Food and Drug Administration. Please consult your doctor and learn about available studies before using them. This product is not intended to diagnose, treat, cure or prevent any disease.
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