Orlistat Raw Powder CAS 96829-58-2

Orlistat raw powder belongs to tetrahydrolipstatin, which is a saturated derivative of lipstatin, an effective inhibitor of pancreatic and gastric lipase. The intake of orlistat with diet can inhibit the digestion and absorption of dietary fat, thus reducing calorie intake. Orlistat is a white crystalline powder, almost insoluble in water, easily soluble in chloroform, easily soluble in methanol and ethanol, and easily pyrolyzed, with a melting point of 40℃ ~ 42℃. Its molecule is a diastereomer with four chiral centers, and its ethanol solution has negative optical rotation at the wavelength of 529nm.

What is Orlistat?

Orlistat raw powder is a kind of obesity drug that does not act on the central nervous system. It only acts on the gastrointestinal tract, prevents triacylglycerol from being hydrolyzed into free fatty acids and Monoacylglycerides by inhibiting lipase in the gastrointestinal tract, reduces the absorption of dietary fat (triacylglycerol) by the intestinal mucosa, and promotes the elimination of fat from the body. Lipase is an essential enzyme for decomposing fat in the gastrointestinal tract. It can combine with serine residues of lipase in the stomach and pancreas to inactivate lipase, make it unable to decompose fat in food into free fatty acids, and inhibit the utilization and absorption of fat. Besides, it can also reduce the risk factors related to obesity.

What is the role of orlistat?

Orlistat raw powder is a reversible inhibitor of gastrointestinal lipase, which inactivates the enzyme by forming covalent bonds with the active serine sites of gastric lipase and pancreatic lipase in the stomach and small intestine cavity. The inactivated enzyme cannot hydrolyze the fat (mainly triglyceride) in food into absorbable free fatty acids and monoacylglycerol. Undigested triglycerides can not be absorbed by the body, thus reducing calorie intake and controlling weight. It does not need to exert its efficacy through systemic absorption.

Why is there orlistat?

Obesity refers to a certain degree of obvious overweight and excessive fat layer, which is a state caused by excessive accumulation of body fat, especially triglyceride. Excessive body fat accumulation caused by excessive food intake or changes in body metabolism leads to excessive weight gain and changes in human pathology and physiology.

Obesity is one of the most headache problems of modern people. With the improvement of living standards, people generally eat well and exercise less. In addition, with the high-tech and intelligent era, the physical strength consumption of human beings has been greatly reduced, resulting in a sharp increase in the number of obese people.

Maybe you don't know it. At present, there is only one legal weight-loss drug approved in China, and it is orlistat.

Orlistat, the first prescription drug for weight loss approved by FDA in 1999, was listed in many countries around the world in 2000, listed in China in 2001, and approved as an over-the-counter weight loss drug in 2007.

Orlistat combined with a micro-low calorie diet is suitable for the long-term treatment of obese and overweight people, including those who have developed risk factors related to obesity.

Orlistat has a long-term weight control effect. The use of orlistat can reduce the risk factors related to obesity and the incidence of other diseases related to obesity.

What are the adverse reactions of orlistat?

Orlistat is a gastrointestinal reaction, which is related to the pharmacological action of drugs to prevent the absorption of ingested fat. Manifestations: oily spots, increased gastrointestinal exhaust, the urgency of stool, fatty (oily) stool, fatty diarrhea, increased stool frequency, and fecal incontinence.

Other rare adverse events were: upper respiratory tract infection, lower respiratory tract infection, influenza, headache, menstrual disorder, anxiety, fatigue, and urinary tract infection.

Post-marketing monitoring found that there were rare reports of elevated transaminase, elevated alkaline phosphatase, and severe hepatitis after using orlistat, and there were cases of liver failure, some of which needed liver transplantation or could directly lead to death. At present, the relationship between using orlistat and severe liver damage could not be confirmed. There are also reports of rare allergic reactions of orlistat, the main clinical manifestations of which are pruritus, rash, urticaria, angioneurotic edema, bronchospasm, and allergic reactions, and it is very rare to have large herpes. Post-marketing monitoring also found reports of pancreatitis.

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Note: This compound should be used for research purposes only. These claims have not been evaluated by the Food and Drug Administration. Please consult your doctor and learn about available studies before using them. This product is not intended to diagnose, treat, cure or prevent any disease.

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