Raw Material Powder Baclofen CAS 1134-47-0

Raw Material Powder Baclofen,γ- A derivative of aminobutyric acid, an antispasmodic drug, it is a skeletal muscle relaxant and sedative acting on the brain and spinal cord of the central nervous system. It inhibits the release of excitatory amino acids such as glutamate and aspartate by stimulating receptors, so as to inhibit the transmission of monosynaptic and polysynaptic reflex in the brain and spinal cord of the central nervous system, so as to play a spasmolysis role. As a racemic preparation, it has been used in the treatment of muscle spasms since the mid-1960s. Recent studies have also found that this product can significantly reduce gastroesophageal reflux and improve its symptoms, effectively alleviate the symptoms of dystonia in children, and treat micturition dysfunction after central intractable spinal cord injury. In addition, the clinical application of intrathecal use therapy can further improve the clinical efficacy, adjust the drug dosage at any time and stabilize the treatment effect. In recent 10 years, great progress has been made in the clinical application of central muscle relaxant baclofen, especially in nerve rehabilitation treatment to reduce muscle tension and pain relief.

Action mechanism of this product

γ- The content of aminobutyric acid (GABA) in the brain and spinal cord of the human central nervous system is very high, which is more than 1000 times higher than that of monoamines in the brain, such as catecholamine, norepinephrine, and dopamine. Among them, the content in substantia nigra and globus pallidus is the highest, and GABA is used as the transmitter in about 20-40% of synapses in the brain. GABA is the main inhibitory transmitter in the brain and spinal cord of the central nervous system, but it cannot pass through the blood-brain barrier. GABA changes into Raw Material Powder Baclofen by connecting para chlorophenyl to a carbon atom and changes from hydrophilic substance to lipophilic substance, so it can penetrate the blood-brain barrier. The main function of this product is to activate GABA receptors, inhibit the release of excitatory amino acids such as aspartate and glutamate through synapses, make K + and GA + 2 ions in neurons outflow, produce hyperpolarization, reduce the transmission of monosynaptic and polysynaptic reflex, promote the normal activity of interneurons and reduce the activity of motor neurons, so as to alleviate the spasticity of skeletal muscle caused by pyramidal tract damage and reduce muscle tension, promote the recovery of motor function.

What are the adverse reactions and precautions of this product?

The main adverse effects of Raw Material Powder Baclofen in elderly patients, such as mild sedative and vascular side effects, may be the onset of excessive doses of chlorine, and severe side effects in elderly patients. Therefore, we should be very careful in use. Especially when the curative effect is not very ideal, do not increase the dosage according to your will. The main manifestations of overuse are the most prominent signs of inhibition of the central nervous system. Severe poisoning is characterized by seizures, coma, respiratory depression, and hypotonia with limb reflex loss. Bradycardia and hypotension have also been observed. First-aid measures for acute poisoning include respiratory support, gastric lavage, and diuresis. There are no special antidotes. It has been reported that some patients have seizures and myoclonic convulsions during recovery. Seizures can be treated with diazepam or clonazepam, although these drugs may prolong the duration of unconsciousness. Patients with cardiovascular disease should be carefully observed for 1 week to monitor late-onset tachycardia and hypertension. If you take the medicine on time, but you are allergic to the medicine or suffer from Parkinson's disease, finger spasms,s and are pregnant women in the first three months of pregnancy, you should not use it. Use with caution for patients with hypertension, peptic ulcer disease, cerebrovascular disease and respiration, liver and kidney dysfunction, history of epilepsy or convulsion, mental disorder, schizophrenia or confusion, pregnant and lactating women, drivers, or operators of machines. Epilepsy patients need to control seizures with this product, and EEG monitoring should be done. If you feel your condition is alleviated, you should slowly reduce the use of this product before stopping the drug to prevent rebounds or other physical discomforts.

What are the indications of this product?

Baclofen powder is an antispasmodic drug. It can inhibit the spinal cord transmission of monosynaptic and multisynaptic. Its mechanism is to activate the GABA receptors and inhibit the release of excitatory amino acids glutamate and aspartate. Therefore, it can reduce the increase of limb muscle tension caused by myelopathy, multiple sclerosis, and spinal cord injury. Used for muscle spasms caused by spinal cord and brain diseases or injuries.

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