Ponazuril Introduction
Xi'an Faithful BioTech Co., Ltd. is an export-oriented biotechnology and chemical trading company headquartered in Xi'an, Shaanxi Province, China. Founded in 2018, the company focuses on providing pharmaceutical intermediates, plant extracts, food additives, and feed ingredients to the global B2B market.
As a lean, professional supplier, we implement rigorous quality control to ensure batch stability and compliance. With an experienced international sales team, we offer highly competitive prices, reliable delivery times, and one-stop export services.
Our products are widely supplied to the pharmaceutical, health supplement, cosmetic, and feed industries in Europe, North America, Southeast Asia, and the Middle East.
Ponazuri is a white solid with the CAS number 69004-04-2; its molecular formula is C18H14F3N3O6S; its molecular weight is 457.38; and its EINECS number is 629-740-8. This product was developed by the German company Bayer as a new anti-coccidiosis product. It was approved for sale in the United States by the FDA in 2001 and is used to treat central nervous system diseases in mammals caused by coccidia such as Neospora hughesi and Sarcocystis. Compared with the previous anti-coccidiosis product Toltrazuril, the most significant feature of Ponazuril Powder is that it can pass through the blood-brain barrier and directly kill protozoa located in the brain and cerebrospinal fluid, effectively alleviating EPM symptoms. Studies have shown that Ponazuri kills coccidia in animals without affecting the generation of their own immunity. As the animal's own immunity strengthens, the diseased animals can gradually break free from the dependence on the compound.
What is the main use of Ponazuril?
Ponazuril is a triazine-based veterinary deworming raw material powder. It is not usually directly fed to animals but is mainly used by pharmaceutical factories for processing into finished products. The most common application of Ponazuril Powder is in the preparation of oral pastes and premixes, which are used to treat equine protozoal encephalomyelitis (EPM) caused by equine protozoal infection. EPM is a parasitic disease that affects the horse's nervous system, causing problems such as unsteady gait and muscle weakness. In addition, it is also used in the poultry and livestock industries to make compliant veterinary for the prevention and treatment of various protozoal diseases in livestock, reducing problems such as diarrhea, poor growth, and increased mortality rates.
What is the working principle of Ponazuril in animals?
Ponazuril has a highly targeted effect in eliminating parasites. It only acts on parasites belonging to the Cestoda class, such as the cysticercus that causes equine epizootic myeloencephalitis in horses, and the Eimeria that causes coccidiosis in livestock and poultry. These parasites have a unique organelle called the apical body within their bodies, which is responsible for synthesizing L-tert-Leucine and providing energy for the parasites. Mammals like horses, pigs, and chickens do not have this structure in their bodies, so after use, it will only be effective against the parasites and will have almost no harm to the animals themselves.
When Ponazuril Powder comes into contact with the apical body, it completely disrupts the normal survival rhythm of the parasites: the internal cells of the parasite will produce a large number of vacuoles, gradually deteriorate, the mitochondria will expand and deform, and the surface cell membrane will also become deformed and protrude, unable to grow normally; at the same time, it directly blocks the parasite's division and replication, preventing them from reproducing and spreading, and controlling the continuous deterioration of parasitic infections at the root.
MF of Ponazuril
| CAS | 69004-04-2 |
| Molecular formula | C18H14F3N3O6S |
| Molecular weight | 457.38 |
| EINECS | 629-740-8 |
| Melting point | 242° |
| Density | 1.507±0.06 g/cm3 |
Specification
| Item | Specification | Result |
| Appearance | White powder | complies |
| Identification | 1) IR spectra is consistent with CRS | complies |
| 2) The retention time of the major peak in the chromatogram of the assay preparation corresponds to that in the chromatogram of the standard preparation, as obtained in the assay | complies | |
| Related substances | individual impurity≤1.0% | 0.24% |
| Total impuirties ≤2.0% | 0.70% | |
| Loss on ignition | ≤0.5% | 0.32% |
| Residue on ignition | ≤0.1% | 0.05% |
| Heavy metals | ≤ 10 parts per million | ≤ 10 parts per million |
| Assay | ≥98% | 99.40% |
| Conclusion | Conform with enterprise specification | |
Click email：sales6@faithfulbio.com Or WhatsApp：+86 17782780648
A variety of shipping methods for you to choose
| Transportation Time | Shipping method | Cargo weight requirements | Advantage |
| 3-7 days | DHL,Germany DHL,Germany DPD, UPS,USPS,FedEx,TNT,EMS |
Suitable for under 50kg. International door to door express |
We have warehouses in Germany and California, USA, and customers in Europe and America can enjoy sending goods directly from these two places. |
| 7-15 days | By Air | Suitable for more than 50kg. fast and cheaper for large order |
|
| 15-60 days | By Sea | Suitable for more than 500kg. Cheapest shipping way |
Our strengths:
Our company has passed FDA and ISO19001 quality management system certification. And we have internal cooperation agreements with multiple factories and laboratories in China,Our company can provide Ponazuril Powder etc. at a more favorable price. If you are interested, please leave a message.
We not only have unique advantages in transportation, but also support multiple payment methods, whether you use US dollars, euros, Australian dollars, or local currencies from Singapore, Malaysia, Thailand, and so on. We can also support local currencies in these regions and countries. In addition, we also support bank cards (credit cards, etc.) for payments.
FAQ:
Q1:Can Ponazuril be used on pregnant animals?
In veterinary clinical practice, the safety of Ponazuril in pregnant horses is limited. It is usually only considered for use when the benefits outweigh the risks as assessed by the veterinarian, and it cannot be decided independently.
Q2:Is Ponazuril an antibiotic?
No. Ponazuril is a triazine antiparasitic compound that specifically targets parasitic protozoa and has a completely different mechanism of action from antibiotics that kill bacteria.
Q3:What is the difference between Ponazuril and Toltrazuril?
The former has a much lower toxic effect level compared to the latter, and its development prospects are extremely promising.
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