Mefoxin is a beta lactam and cephalosporin antibiotic with bactericidal activity. The molecular formula is C16H17N3O7S2, which is a cephalosporin antibiotic. At room temperature and pressure, Cefoxitin powder is a white to off white crystalline powder with a parent nucleus similar to cephalosporins and similar antibacterial properties. It is commonly classified as a second-generation cephalosporin.
| Molecular formula |
|
|
|
Item |
Specification |
Test Results |
|
Melting Point |
≥149°C |
157 °C |
|
Appearance |
White to off white crystalline powder |
Complies |
|
Identification |
In accord CP2010 |
Complies |
|
Related Substances |
In accord CP2010 |
Complies |
|
Loss on drying |
< 0. 1% |
0.2% |
|
Residue on |
< 0. 1% |
0.04% |
|
Heavy metals |
NMT 10 PPM |
Conforms |
|
Pb |
≤0.5ppm |
0.11ppm |
|
As |
≤0.5ppm |
0.14opm |
|
Related substance |
Max Single Impurity ≤0.5% |
0.14% |
|
Total plate count |
≤1,000cfu/g |
3.28 cfu/g |
|
Mold and Yeast |
≤100cfu/g |
0.12 cfu/g |
|
E.Coli |
Negative |
Negative |
|
Salmonella |
Negative |
Negative |
|
Staphylococcus aureus |
Negative |
Negative |
|
Content content |
99.0%-101.5% |
99.3% |
How many generations of cephalosporins is cefoxitin sodium?
Cefoxitin sodium is a second-generation cephalosporin antibiotic that acts on bacterial cell proteins and has a broader antibacterial spectrum than the first generation cephalosporin drugs. After product comparison, it was found that the effect of this product on Gram positive bacteria is roughly equivalent to that of the first generation cephalosporins. However, the antibacterial range of this product against gram-negative bacteria is wider than that of the first generation, and its antibacterial effect is also stronger; Cefoxitin powder can inhibit bacterial cell wall synthesis, achieving the effect of killing bacteria. It can be used for upper respiratory tract infections and urinary tract infections caused by sensitive bacteria, and can also play a certain role in gynecological infections and pelvic infections. If the patient has a predisposition to allergies, it is not recommended to use CEFOXITIN ACID because it is prone to allergic symptoms such as skin itching, redness, and swelling. For patients with renal dysfunction and gastrointestinal diseases, caution should be exercised as MK-306 may increase physical burden.
What are the related studies and biological activities of Cefoxitin?
FARMOXIN interferes with cell wall synthesis and has strong antibacterial properties in clinical practice, as well as high resistance to β - lactase. Commonly used respiratory infections, endocarditis, peritonitis, pyelonephritis, urinary tract infections, sepsis, and infections of bones, joints, skin, and soft tissues caused by sensitive bacteria. However, due to the high resistance of MK 306 to β - lactase produced by bacteria, it is particularly suitable for mixed infections of aerobic and anaerobic bacteria, as well as other scenarios where patients cannot be treated due to β - lactase. Additionally, Cefoxitin powder also has good effects on Staphylococcus and various streptococci.
In order to investigate the stability of the compatibility of cephoxitin with four hemostatic products (Etamsylate, 4-(Aminomethyl)benzoic acid, Carbazochrome, Aminocaproic Acid), UV spectrophotometry was used to examine the changes in the content of cfx and the four hemostatic drugs within 6 hours. As a result, under room temperature conditions, the content (P>0.05) and appearance of cefoxitin and Etamsylate remained stable within 0-6 hours, but there was a change in pH value (P<0.05) and a change in compatibility with Aminocaproic Acid (P<0.05 after 4 hours). Therefore, it can be concluded that Cefoxitin is relatively stable under acidic conditions and unstable under alkaline conditions. As for the antibacterial mechanism, Cefoxitin powder exerts its antibacterial effect by binding to one or more penicillin binding proteins (PBPs) in bacterial cells, inhibiting the synthesis of cell walls in active dividing cells.
A variety of shipping methods for you to choose
|
Transportation Time |
Shipping method |
Cargo weight requirements |
Advantage |
|
3-7 days |
DHL,Germany DHL,Germany DPD, |
Suitable for under 50kg. |
We have warehouses in Germany and California, USA, |
|
7-15 days |
By Air |
Suitable for more than 50kg. |
|
|
15-60 days |
By Sea |
Suitable for more than 500kg. |
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